Zobrazeno 1 - 10
of 80
pro vyhledávání: '"E. D. Gilles"'
Publikováno v:
The Febs Journal
During liver regeneration, quiescent hepatocytes re-enter the cell cycle to proliferate and compensate for lost tissue. Multiple signals including hepatocyte growth factor, epidermal growth factor, tumor necrosis factor α, interleukin-6, insulin and
Publikováno v:
IET Systems Biology. 3:255-265
The activation of caspases is a central mechanism in apoptosis. To gain further insights into complex processes like this, mathematical modelling using ordinary differential equations (ODEs) can be a very powerful research tool. Unfortunately, the la
Autor:
Luca Simeoni, Stefanie Kliche, Julio Saez-Rodriguez, E. D. Gilles, Andreas Ambach, Burkhart Schraven, Jonathan A. Lindquist, Xiaoqian Wang
Publikováno v:
The Journal of Immunology. 180:6703-6712
Engagement of the TCR can induce different functional outcomes such as activation, proliferation, survival, or apoptosis. How the TCR-mediated signaling cascades generating these distinct cellular responses are organized on the molecular level is so
Publikováno v:
Bioinformatics. 24:704-710
Motivation: In Escherichia coli, the phosphoenolpyruvate: carbohydrate phosphotransferase system acts like a sensory element which is able to measure the flux through glycolysis. Since the output of the sensor, the phosphorylated form of protein EIIA
Publikováno v:
Computing and Visualization in Science. 9:175-183
In this article we present the numerical techniques for and the results of simulations of crystal growth and breakage in a stirred crystallizer. The population dynamics of the crystals is fully coupled with the flow in the tank. Our simulation involv
Autor:
Joerg Stelling, Karin D. Breunig, Kathlen Franke, Hauke Lilie, E. D. Gilles, Alexander Anders, Lutz Kapp
Publikováno v:
Journal of Biological Chemistry. 281:29337-29348
The Gal4 protein represents a universally functional transcription activator, which in yeast is regulated by protein-protein interaction of its transcription activation domain with the inhibitor Gal80. Gal80 inhibition is relieved via galactose-media
Publikováno v:
Biosystems. 78:23-37
A mathematical model for the KdpD/KdpE two-component system is presented and its dynamical behavior is analyzed. KdpD and KdpE regulate expression of the kdpFABC operon encoding the high affinity K+ uptake system KdpFABC of Escherichia coli. The mode
Autor:
R. Waschler, Michael Mangold, Martin Ginkel, O. Angeles-Palacios, E. D. Gilles, Andreas Kremling, Achim Kienle
Publikováno v:
Industrial & Engineering Chemistry Research. 44:2579-2591
Computer tools can support and accelerate the development and implementation of first-principle models for chemical and biological processes significantly. Several application examples illustrate this in the contribution. Models of a biochemical reac
Publikováno v:
IEEE Control Systems. 24:35-52
This paper introduces compelling problems of biological systems and signaling networks to show how engineering tools can be applied to the analysis of the cellular machinery. The mechanisms that cells have developed to process information are describ
Publikováno v:
Biosystems. 73:57-71
The analysis of metabolic pathways with mathematical models contributes to the better understanding of the behavior of metabolic processes. This paper presents the analysis of a mathematical model for carbohydrate uptake and metabolism in Escherichia