Výsledky vyhledávání

Studies of molecular pharmacophore/receptor models for GABAA/benzodiazepine receptor subtypes: binding affinities of substituted beta-carbolines at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis

Autor: Q, Huang, E D, Cox, T, Gan, C, Ma, D W, Bennett, R M, McKernan, J M, Cook

Publikováno v: Drug design and discovery. 16(1)

Binding affinities of a series of 44 beta-carbolines with various substituents at the 3-, 4-, 6- and 7-positions are reported at 5 distinct recombinant GABAA/benzodiazepine receptor (BzR) subtypes [alpha x beta 3 gamma 2 (x = 1-3, 5, 6)]. Many of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::984fcbae3967dc44598d4e9100cc3707
https://pubmed.ncbi.nlm.nih.gov/10466057

Zobrazit plný text záznamu

Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors

Autor: E D, Cox, H, Diaz-Arauzo, Q, Huang, M S, Reddy, C, Ma, B, Harris, R, McKernan, P, Skolnick, J M, Cook

Publikováno v: Journal of medicinal chemistry. 41(14)

A pharmacophore and an alignment rule have previously been reported for BzR agonist ligands. The design and synthesis of 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC, 24, IC50 = 8.1 nM) was based on this pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a07f920b77df3327a4065be30be37731
https://pubmed.ncbi.nlm.nih.gov/9651158

Zobrazit plný text záznamu

A collection of experiments for teaching photochemistry (Technical Report)

Autor: Maria de Graça M. Miguel, I. Kamiya, T. W. Ebbesen, E. D. Cox, Hugh D. Burrows, Augusto C. Cardoso, S. Yanagida, J. D. Coyle, J. H. Penn, M. Sasaki, K. Nakamura, Sebastião J. Formosinho, M. Kawahigashi, S. Hirayama, E. Fanghanel, K. Tokumaru

Publikováno v: Pure and Applied Chemistry. 64:1343-1344

A selection of experiments in photochemistry, appropriate for first year undergraduate level students is presented. An extensive bibliography to further reading is provide.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5604b5c7530ebf80297cda3bcc36f22
https://doi.org/10.1351/pac199264091343

Zobrazit plný text záznamu

Personalising wound care: A gene expression signature for predicting clinical outcomes of venous leg ulcers

Autor: A. Sanders, E. D. Cox, Keith G Harding, Jane Lane, F. Ruge, David C. Bosanquet, Wen Guo Jiang

Publikováno v: International Journal of Surgery. :S20

s / International Journal of Surgery 23 (2015) S15eS134 S20 characteristics on a suitable polymer with ideal bulk properties provides a basis for further research into the effects of PSM on cell behaviour. 0171: PERSONALISING WOUND CARE: A GENE EXPRE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7267b6e0ddec6f302f8bd639fce648

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání