Plasma polymerized nanoparticles are a safe platform for direct delivery of growth factor therapy to the injured heart

Autor: Zoë E. Clayton, Miguel Santos, Haisam Shah, Juntang Lu, Siqi Chen, Han Shi, Shaan Kanagalingam, Praveesuda L. Michael, Steven G. Wise, James J. H. Chong

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Introduction: Heart failure due to myocardial infarction is a progressive and debilitating condition, affecting millions worldwide. Novel treatment strategies are desperately needed to minimise cardiomyocyte damage after myocardial infarction and to

Externí odkaz: https://doaj.org/article/f8c972cb10c54106b3cb35d771e370d4

Chromosomally unstable tumor cells specifically require KIF18A for proliferation

Autor: Carolyn Marquis, Cindy L. Fonseca, Katelyn A. Queen, Lisa Wood, Sarah E. Vandal, Heidi L. H. Malaby, Joseph E. Clayton, Jason Stumpff

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Kinesin motor proteins are critical for maintaining mitotic spindle integrity, which is important for chromosome stability. Here, the authors show that the kinesin motor protein, KIF18A, permits the proliferation of chromosomally unstable cells and k

Externí odkaz: https://doaj.org/article/155fe186fe17428f9306cda918e23864

Induced endothelial cells from peripheral arterial disease patients and neonatal fibroblasts have comparable angiogenic properties

Autor: Jack D. Hywood, Sara Sadeghipour, Zoe E. Clayton, Jun Yuan, Colleen Stubbs, Jack W. T. Wong, John P. Cooke, Sanjay Patel

Publikováno v: PLoS ONE, Vol 16, Iss 8 (2021)

Induced endothelial cells (iECs) generated from neonatal fibroblasts via transdifferentiation have been shown to have pro-angiogenic properties and are a potential therapy for peripheral arterial disease (PAD). It is unknown if iECs can be generated

Externí odkaz: https://doaj.org/article/968c8f3c7a684dcdbfd1764f40d6759d

Safety and Efficacy of Pediatric Growth Hormone Therapy

Autor: Mohamad Maghnie, Michael B Ranke, Mitchell E Geffner, Elpis Vlachopapadopoulou, Lourdes Ibáñez, Martin Carlsson, Wayne Cutfield, Raoul Rooman, Roy Gomez, Michael P Wajnrajch, Agnès Linglart, Renata Stawerska, Peter E Clayton, Feyza Darendeliler, Anita C S Hokken-Koelega, Reiko Horikawa, Toshiaki Tanaka, Helmuth-Günther Dörr, Kerstin Albertsson-Wikland, Michel Polak, Adda Grimberg

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 107(12), 3287-3301. Endocrine Society
Maghnie, M, Ranke, M B, Geffner, M E, Vlachopapadopoulou, E, Ibáñez, L, Carlsson, M, Cutfield, W, Rooman, R, Gomez, R, Wajnrajch, M P, Linglart, A, Stawerska, R, Clayton, P E, Darendeliler, F, Hokken-Koelega, A C S, Horikawa, R, Tanaka, T, Dörr, H G, Albertsson-Wikland, K, Polak, M & Grimberg, A 2022, ' Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort ', The Journal of Clinical Endocrinology & Metabolism . https://doi.org/10.1210/clinem/dgac517

Context The Kabi/Pfizer International Growth Database (KIGS) is a large, international database (1987-2012) of children treated with recombinant human growth hormone (rhGH) in real-world settings. Objective This work aimed to evaluate the safety and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc764b4cf7e8d0fa5017f08cc6f7406
https://doi.org/10.1210/clinem/dgac517

The endoplasmic reticulum-associated mRNA-binding proteins ERBP1 and ERBP2 interact in bloodstream-form Trypanosoma brucei

Autor: Kathrin Bajak, Kevin Leiss, Christine E. Clayton, Esteban Erben

Publikováno v: PeerJ, Vol 8, p e8388 (2020)

Kinetoplastids rely heavily on post-transcriptional mechanisms for control of gene expression, and on RNA-binding proteins that regulate mRNA splicing, translation and decay. Trypanosoma brucei ERBP1 (Tb927.10.14150) and ERBP2 (Tb927.9.9550) were pre

Externí odkaz: https://doaj.org/article/f10bba4ab9fa407b9b4e0805d1ca2977