Zobrazeno 1 - 10
of 34
pro vyhledávání: '"E. Clatworthy"'
Autor:
Alexander Sturm, Penny Sun, Julian Avila-Pacheco, Anne E. Clatworthy, Zohar Bloom-Ackermann, Michael G. Wuo, James E. Gomez, Soomin Jin, Clary B. Clish, Laura L. Kiessling, Deborah T. Hung
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Mycobacterium tuberculosis (Mtb) can adopt a non-growing dormant state during infection that may be critical to both active and latent tuberculosis. During dormancy, Mtb is widely tolerant toward antibiotics, a significant obstacle in curren
Externí odkaz:
https://doaj.org/article/3478c905ccf4486081f42e2a0d6d8f81
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Animals rely heavily on their nervous and immune systems to perceive and survive within their environment. Despite the traditional view of the brain as an immunologically privileged organ, these two systems interact with major consequences.
Externí odkaz:
https://doaj.org/article/1fffe43ab261482d952779d3b1312877
Publikováno v:
Cell Chem Biol
The golden age of antibiotic discovery in the 1940s-1960s saw the development and deployment of many different classes of antibiotics, revolutionizing the field of medicine. Since that time, our ability to discover antibiotics of novel structural cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5dd00b4a42dfc3e3bc9c8659b3c8e2
https://europepmc.org/articles/PMC9893512/
https://europepmc.org/articles/PMC9893512/
Publikováno v:
Methods in Molecular Biology ISBN: 9781071617199
Transposon-insertion sequencing (Tn-Seq) allows for identification of bacterial genes and pathways essential for growth under a given condition. A transposon mutant is created by the stable and random integration of a transposable element into a geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43ddf05718af17540f172b4c7c15fd0b
https://doi.org/10.1007/978-1-0716-1720-5_10
https://doi.org/10.1007/978-1-0716-1720-5_10
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2377
Transposon-insertion sequencing (Tn-Seq) allows for identification of bacterial genes and pathways essential for growth under a given condition. A transposon mutant is created by the stable and random integration of a transposable element into a geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da896afc1640057bcdacb3dc0f208cf2
https://pubmed.ncbi.nlm.nih.gov/34709617
https://pubmed.ncbi.nlm.nih.gov/34709617
Autor:
N. Barrier, M. Debost, J. Grand, P. Boullay, E. Clatworthy, A. Päcklar, P. Klar, P. Brázda, N. Nesterenko, J.P. Dath, J.P. Gilson, L. Palatinus, S. Mintova
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 78:e711-e711
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b4db08ebc381e47586bd3cb77f4970
https://doi.org/10.1107/s2053273322090672
https://doi.org/10.1107/s2053273322090672
Autor:
Christoph M. Ernst, Anil V. Nair, Ashlee M. Earl, Lisa A. Cosimi, Deborah T. Hung, Kaelyn C. Cummins, Abigail L. Manson, Anne E. Clatworthy, Carlos A. Rodriguez-Osorio, Alejandro Pironti, Maura E. Benson, Li Li, Julian R. Braxton, Anna P. Zagieboylo
Publikováno v:
Nat Med
Among the most urgent public health threats is the worldwide emergence of carbapenem-resistant Enterobacteriaceae1–4, which are resistant to the antibiotic class of ‘last resort’. In the United States and Europe, carbapenem-resistant strains of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fc8a61daf9a48e7e9aa747d2c9844c
https://europepmc.org/articles/PMC9194776/
https://europepmc.org/articles/PMC9194776/
Autor:
Patrick McCarren, Partha P. Nag, Robert Jedrzejczak, Anne E. Clatworthy, Stewart L. Fisher, Stephen Johnston, Karolina Michalska, Noman Siddiqi, Besnik Bajrami, Stuart L. Schreiber, Andrzej Joachimiak, Samantha Wellington, Natalia Maltseva, Deborah T. Hung, Senya Combs, Virendar K. Kaushik
Publikováno v:
Nature Chemical Biology. 13:943-950
New antibiotics with novel targets are greatly needed. Bacteria have numerous essential functions, but only a small fraction of such processes-primarily those involved in macromolecular synthesis-are inhibited by current drugs. Targeting metabolic en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2516359430453acd65f16cde0311e05f
https://doi.org/10.1038/nchembio.2420
https://doi.org/10.1038/nchembio.2420
Autor:
Christoph M. Ernst, Abigail L. Manson, Ashlee M. Earl, Julian R. Braxton, Lisa A. Cosimi, Deborah T. Hung, Anil V. Nair, Maura E. Benson, Kaelyn C. Cummins, Alejandro Pironti, Carlos A. Rodriguez-Osorio, Li Li, Anna P. Zagieboylo, Anne E. Clatworthy
Publikováno v:
Nature Medicine. 26:1307-1307
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd59f5b7ad42b280032a8ed0eb33562d
https://doi.org/10.1038/s41591-020-0974-5
https://doi.org/10.1038/s41591-020-0974-5
Autor:
Anne E. Clatworthy, Li Li, Tiantian White, Noam Shoresh, Sarah J. Osmulski, Rui Yang, Cristina Penaranda, Deborah T. Hung, Bradley E. Poulsen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Current antibiotics are increasingly ineffective due to rising resistance, and antibiotic discovery campaigns frequently fail. One key factor in effective antibiotic discovery is knowing whether a target’s function is essential in a ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58df0aeb508285fba07552c291f4efa