Zobrazeno 1 - 10
of 571
pro vyhledávání: '"E. Chadwick"'
Autor:
Amy Louise Ball, Carol E Jolly, Mark G Lennon, Jonathan J Lyon, Ana Alfirevic, Amy E Chadwick
Publikováno v:
eLife, Vol 12 (2023)
Background: Evidence supports an important link between mitochondrial DNA (mtDNA) variation and adverse drug reactions such as idiosyncratic drug-induced liver injury (iDILI). Here, we describe the generation of HepG2-derived transmitochondrial cybri
Externí odkaz:
https://doaj.org/article/cac0c9cc70c841ffb77c6bdfa52724f5
Autor:
Sean Brennan, Simona Esposito, Muhammad I. M. Abdelaziz, Christopher A. Martin, Samir Makwana, Mark W. Sims, Iain B. Squire, Parveen Sharma, Amy E. Chadwick, Richard D. Rainbow
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Hyperglycaemia at the time of myocardial infarction has an adverse effect on prognosis irrespective of a prior diagnosis of diabetes, suggesting glucose is the damaging factor. In ex vivo models of ischaemia, we demonstrated that deleterious effects
Externí odkaz:
https://doaj.org/article/61cc3fe6d8c84613ac2712b76fa236b6
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1485 (2023)
The United States Food and Drug Administration Adverse Event Reporting System (FAERS) logged 27,140 rhabdomyolysis cases from 2004 to 31 March 2020. We used FAERS to identify 14 drugs frequently reported in 6583 rhabdomyolysis cases and to investigat
Externí odkaz:
https://doaj.org/article/d4d76d1a261c418aaf74261640b3977d
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Background: The triad of drug efficacy, toxicity and resistance underpins the risk-benefit balance of all therapeutics. The application of pharmacogenomics has the potential to improve the risk-benefit balance of a given therapeutic via the stratific
Externí odkaz:
https://doaj.org/article/0c08f4c6c592408ba7599d66c364696c
Publikováno v:
eLife, Vol 9 (2020)
A structural motif that is found in two cancer drugs may be responsible for their ability to tackle cancers and for the side-effects caused by the drugs.
Externí odkaz:
https://doaj.org/article/e99074dc197a42c98e777ee538658ac8
Autor:
L. Liborio, P. Austin, A. Gonzalez-Beltran, E. Chadwick, V. Savchenko, A. Neronov, J. Iaquinta, A. Bretaudeau
The Galaxy platform has been designed as science domain-neutral and, recently, it has been expanding into new scientific communities. In this talk I will present examples from our work in the EuroScienceGateway project, which aims to leverage Europea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6596bea507a462cbfcec3572a57e41ed
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Nelson M Patterson, Benjamin R Bates, Amy E Chadwick, Claudia Nieto-Sanchez, Mario J Grijalva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 9, p e0006841 (2018)
BACKGROUND:Chagas disease (CD) is a life-threatening illness caused by the protozoan parasite Trypanosoma cruzi, which is transmitted by triatomine bugs. Triatomine bugs inhabit poorly constructed homes that create multiple hiding spots for the bugs.
Externí odkaz:
https://doaj.org/article/44f1574051064b72961a7140e6d2ca4c
Autor:
Ross A Kelly, Joseph Leedale, Andy Harrell, Daniel A Beard, Laura E Randle, Amy E Chadwick, Steven D Webb
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207803 (2018)
Cancer cells depend on glucose metabolism via glycolysis as a primary energy source, despite the presence of oxygen and fully functioning mitochondria, in order to promote growth, proliferation and longevity. Glycolysis relies upon NAD+ to accept ele
Externí odkaz:
https://doaj.org/article/6175f3db99624567aabd4c19c5b8a565
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177951 (2017)
Bioenergetics of artery smooth muscle cells is critical in cardiovascular health and disease. An acute rise in metabolic demand causes vasodilation in systemic circulation while a chronic shift in bioenergetic profile may lead to vascular diseases. A
Externí odkaz:
https://doaj.org/article/caec8bebe72b43ada176d051eb8a56a4