Zobrazeno 1 - 10
of 21
pro vyhledávání: '"E. C. Klasen"'
Publikováno v:
Clinical Genetics. 29:211-215
A significantly higher number of PI ZZ and PI MZ individuals was found in a flaccid lung population as compared to internal and healthy controls. The relative risk for ZZ is 12.5 and for MZ 1.8. We conclude that if a PI MZ individual does develop lun
Publikováno v:
Nederlands tijdschrift voor geneeskunde. 149(36)
To determine the number and type of medical specialists in Dutch hospitals that were authors of scientific papers published in English in the field of clinical drug research in the period 1997/'03.Descriptive.PubMed was searched for articles on clini
Publikováno v:
Nederlands tijdschrift voor geneeskunde. 147(28)
This paper describes the laborious and lengthy path to clarification and disclosure in a case of fraud in a neurological pharmaceutical clinical trial in the Netherlands. A Dutch neurologist was suspected of irregularities within the context of the '
Autor:
H L, Hoeksema, E C, Klasen
Publikováno v:
Nederlands tijdschrift voor geneeskunde. 145(1)
The Council for Medical and Health Research (MW-NWO) assessed the scientific quality of research proposals submitted to the Dutch Investigative Medicine Fund, and analysed if there had been changes over time in the proportion of proposals which the M
Publikováno v:
Nederlands tijdschrift voor geneeskunde. 143(1)
In the Netherlands, the SGO Health Research Promotion Programme was carried out from 1986 until 1997. The aim of the programme was to strengthen patient-oriented clinical research in specific fields of medicine. Some of the programme sections certain
Publikováno v:
Nederlands tijdschrift voor geneeskunde. 141(25)
The enhancement of clinical scientific research in the Netherlands is being stimulated to a substantial extent by the introduction and stimulation of a training model aimed at the combined training of physicians to both a general practitioner or spec
Autor:
E. C. Klasen, T. Nukiwa, Marten H. Hofker, Rune R. Frants, D. Curiel, M. Nelen, Ronald G. Crystal
Publikováno v:
Biochemical and Biophysical Research Communications. 155:634-642
Cosmid clones containing alpha 1-antitrypsin (alpha 1AT) gene sequences were observed to contain alpha 1AT-like sequences approximately 12 kb downstream of the authentic alpha 1AT gene. Restriction mapping suggested the alpha 1AT-like gene lacks prom
Autor:
E. C. Klasen, L. N. Went
Publikováno v:
Annals of Human Genetics. 48:105-117
Summary An exhaustive study of erythropoietic protoporphyria in the Netherlands led to the discovery of 200 patients with this disorder in 91 families. In 46 of these families a single patient occurred. A study of parents, sibs and children led to th
Autor:
D.M. van den Boomgaard, I. Biemond, E C Klasen, C. B. H. W. Lamers, A.S. Peña, J. Kreuning, J. G Goedhard
Publikováno v:
Digestion. 39:20-25
Hereditary alpha 1-antitrypsin (alpha 1-AT) deficiency has been suggested to be associated with peptic ulcer disease. Since the serum concentration of the enzyme is the result of both hereditary and nonhereditary factors, we have studied not only the
Publikováno v:
Human Heredity. 37:340-344
2,000 male individuals randomly selected from three different areas in The Netherlands were phenotyped for apolipoprotein E. The apolipoprotein E gene frequencies and phenotype distribution did not differ significantly from that of previously studied