Zobrazeno 1 - 10
of 352
pro vyhledávání: '"E. Broughton"'
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionSerum symmetric dimethylarginine (SDMA) and creatinine are commonly used biomarkers of renal function in cats. We hypothesize that the serum analytes creatinine and SDMA are equally effective at detecting impaired renal function caused by
Externí odkaz:
https://doaj.org/article/d29ffe0c14b242afab698ffa7bdd1afc
Autor:
Elizabeth J. Elsmo, Arno Wünschmann, Kimberlee B. Beckmen, Liam E. Broughton-Neiswanger, Elizabeth L. Buckles, Jayne Ellis, Scott D. Fitzgerald, Robert Gerlach, Shawna Hawkins, Hon S. Ip, Julia S. Lankton, Erin M. Lemley, Julianna B. Lenoch, Mary L. Killian, Kristina Lantz, Lindsey Long, Roger Maes, Marta Mainenti, Julie Melotti, Megan E. Moriarty, Shotaro Nakagun, Rachel M. Ruden, Valerie Shearn-Bochsler, Danielle Thompson, Mia K. Torchetti, Arnaud J. Van Wettere, Annabel G. Wise, Ailam L. Lim
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 12, Pp 2451-2460 (2023)
We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus of Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout the United States during April 1‒July 21, 2022. Affecte
Externí odkaz:
https://doaj.org/article/0ebeedab626a45d0a1caa750081309b4
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 1, Pp 80-91 (2023)
Abstract Background Ionized calcium concentration ([iCa]) is more sensitive for detecting calcium disturbances than serum total calcium concentration but literature on ionized hypercalcemia in cats is limited. Urolithiasis is a possible adverse conse
Externí odkaz:
https://doaj.org/article/376cd4a8803f4cd1a0693d5d26ebbc30
Autor:
Liam E Broughton-Neiswanger, Sol M Rivera-Velez, Martin A Suarez, Jennifer E Slovak, Pablo E Piñeyro, Julianne K Hwang, Nicolas F Villarino
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228989 (2020)
Prediction and early detection of kidney damage induced by nonsteroidal anti-inflammatories (NSAIDs) would provide the best chances of maximizing the anti-inflammatory effects while minimizing the risk of kidney damage. Unfortunately, biomarkers for
Externí odkaz:
https://doaj.org/article/d65090fe4d434c9abd622c808559f4e6
Autor:
Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Winnie L. Kan, Emma F. Barry, Mara Dottore, Karen S. Cheung Tung Shing, Craig J. Morton, Urmi Dhagat, Matthew P. Hardy, Nicholas J. Wilson, Matthew T. Downton, Christine Schieber, Timothy P. Hughes, Angel F. Lopez, Michael W. Parker
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The N-terminal domain (NTD) of interleukin-3 receptor α-subunit (IL3Rα) is involved in IL-3 recognition but the underlying mechanism is unknown. Here, the authors present crystal structures of the IL3Rα complex and provide biochemical evidence tha
Externí odkaz:
https://doaj.org/article/a177e8976263487282e8d1895527256b
Autor:
Winnie L. Kan, Urmi Dhagat, Kerstin B. Kaufmann, Timothy R. Hercus, Tracy L. Nero, Andy GX. Zeng, John Toubia, Emma F. Barry, Sophie E. Broughton, Guillermo A. Gomez, Brooks A. Benard, Mara Dottore, Karen S. Cheung Tung Shing, Helena Boutzen, Saumya E. Samaraweera, Kaylene J. Simpson, Liqing Jin, Gregory J. Goodall, C. Glenn Begley, Daniel Thomas, Paul G. Ekert, Denis Tvorogov, Richard J. D'Andrea, John E. Dick, Michael W. Parker, Angel F. Lopez
Publikováno v:
Cancer Discovery.
Leukemia stem cells (LSC) possess distinct self-renewal and arrested differentiation properties that are responsible for disease emergence, therapy failure and recurrence in acute myeloid leukemia (AML). Despite AML displaying extensive biological an
Autor:
O. Oikonomidou, E. Galve-Calvo, A. Wöckel, R. Parikh, A. Hitchens, C. Chen, E. Gauthier, B. Li, V. Derrien Ansquer, G. Frugier, M. Jimenez, K. Davis, E. Broughton
Publikováno v:
ESMO Open. 8:101402
Autor:
R.L. Mahtani, K.A. Hanson, K. Lewis, G. Foley, A. Lambert, E. Broughton, C. Chen, C. Criscitiello
Publikováno v:
ESMO Open. 8:101415
Autor:
Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F. Barry, Winnie L. Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J. Busfield, Catherine M. Owczarek, Andrew D. Nash, Nicholas J. Wilson, Michael W. Parker, Angel F. Lopez
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 410-419 (2014)
Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα) in complex with the anti-leukemia
Externí odkaz:
https://doaj.org/article/06924e2c5a1a4bf8928942626539913b
Autor:
Augusta E Broughton, Christopher T. Boughter, Amrita Ramesh, Caitlin D. Castro, Erin J. Adams
Publikováno v:
Immunological Reviews. 298:134-152
As interest increases in harnessing the potential power of tissue-resident cells for human health and disease, γδ T cells have been thrust into the limelight due to their prevalence in peripheral tissues, their sentinel-like phenotypes, and their u