Zobrazeno 1 - 10
of 19
pro vyhledávání: '"E. Brachman"'
Autor:
Erin E. Brachman, Eric B. Kmiec
Publikováno v:
DNA Repair. 4:445-457
The repair of point mutations directed by modified single-stranded DNA oligonucleotides is dependent on the activity of proteins involved in homologous recombination (HR). As a consequence, factors that stimulate homologous recombination, such as dou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56318595aae4cbc0e63b842506443f84
https://doi.org/10.1016/j.dnarep.2004.11.007
https://doi.org/10.1016/j.dnarep.2004.11.007
Publikováno v:
Gene Therapy. 12:639-646
The capacity to correct a mutant gene within the context of the chromosome holds great promise as a therapy for inherited disorders but fulfilling this promise has proven to be challenging. However, steady progress is being made and the development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0703f8dd269e091dc3fb81fd5e2d1d93
https://doi.org/10.1038/sj.gt.3302511
https://doi.org/10.1038/sj.gt.3302511
Autor:
Eric B. Kmiec, Erin E. Brachman
Publikováno v:
Journal of cell science. 117(Pt 17)
The repair of point mutations can be directed by modified single-stranded DNA oligonucleotides and regulated by cellular activities including homologous recombination, mismatch repair and transcription. Now, we report that DNA replication modulates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084b9ee6d70ea08a225f3c36f2bfeb48
https://pubmed.ncbi.nlm.nih.gov/15265980
https://pubmed.ncbi.nlm.nih.gov/15265980
Autor:
Erin E. Brachman, Eric B. Kmiec
Modified single-stranded DNA oligonucleotides have been used to direct base changes in the CYC1 gene of Saccharomyces cerevisiae. In this process, the oligonucleotide is believed to hybridize to the target site through the action of a DNA recombinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a446b975c595f8245535e3d7306e73e3
https://europepmc.org/articles/PMC1462467/
https://europepmc.org/articles/PMC1462467/
Autor:
Erin E, Brachman, Eric B, Kmiec
Publikováno v:
Current opinion in molecular therapeutics. 4(2)
Targeted gene repair is a powerful yet controversial technique invented to direct single-base changes in chromosomal genes. The reaction mechanism has only recently come to light, and parameters that confer a level of control on the frequency of repa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9763548ee79812b44d1779d92b3f6690
https://pubmed.ncbi.nlm.nih.gov/12044039
https://pubmed.ncbi.nlm.nih.gov/12044039
Publikováno v:
Molecular Therapy. 11:S149
Our laboratory has been studying the mechanism and regulation of targeted gene repair in mammalian cells. Using a robust cell line where the genomic correction frequencies average 1%, we have been able to modulate the process of DNA replication and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6937d0daa6e1fb497964ec08ad8b70d4
https://doi.org/10.1016/j.ymthe.2005.06.388
https://doi.org/10.1016/j.ymthe.2005.06.388
Publikováno v:
Molecular Therapy. 11:S146
Top of pageAbstract We have been investigating the mechanism of targeted gene repair in mammalian cells using an eGFP reporter system. The protocol involves the electroporation of single-stranded oligonucleotides into an adenocarcinoma cell line cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca1eb90de3e81b24f6faff421a70161
https://doi.org/10.1016/j.ymthe.2005.06.378
https://doi.org/10.1016/j.ymthe.2005.06.378
Autor:
J. Engler, K. Pack, W. Flauger, Yu.V. Galaktionov, O. Zeldovich, Yu. Kamishkov, Herwig Schopper, G.P. Eliseev, V. Tiunchik, E. Brachman, A. Ermilov, Yu. Gorodkov, V. Böhmer, V. Lubimov, H. Keim, F. Mönnig, Vitaliy G. Shevchenko, L.A. Ponomarev, E. M. Leikin, A. Babaev
Publikováno v:
Nuclear Physics B. 116:28-50
The diffraction dissociation reaction n + p → (pπ−) + p was studied at the Serpukhov accelerator neutron beam in the momentum range 35–65 GeV/c in an electronics experiment. The differential cross sections of the reaction are analysed and pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9939059667420631ccc94f2dc98d6b7
https://doi.org/10.1016/0550-3213(76)90310-2
https://doi.org/10.1016/0550-3213(76)90310-2
Autor:
B. I. Goryachev, N. Balamatov, Yu. Galaktionov, E. Brachman, E. M. Leikin, V. Nagovitzin, E. Shumilov, N.N. Lugetsky, Vitaliy G. Shevchenko, V. Nozik, V. Titov, A. Babaev, G.P. Eliseev, O. Zeldovich, A. Sirotkin, Yu. Kamishkov, T. Zvetkova, V. Lubimov, A. Ermilov, V. Turin
Publikováno v:
Physics Letters B. 51:501-504
The results of the total cross section measurements of neutrons on protons, deuterons and nuclei C, O, Al, Cu, Sn, Pb in the energy range of 28–54 GeV are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83766a16d3ccf38daccc58d3a9321418
https://doi.org/10.1016/0370-2693(74)90321-9
https://doi.org/10.1016/0370-2693(74)90321-9
Autor:
Yu.V. Galaktionov, O. Zeldovich, E. Brachman, Herwig Schopper, W. Flauger, Yu. Kamishkov, E. M. Leikin, K. Pack, V. Böhmer, V. Lubimov, J. Engler, A. Babaev, Yu. Gorodkov, A. Ermilov, H. Keim, G.P. Eliseev, F. Mönnig, Vitaliy G. Shevchenko
Publikováno v:
Nuclear Instruments and Methods. 122:313-318
The response of a sampling total absorption counter (STAC) to protons, neutrons, pions, and electrons with incident energies up to 60 GeV is described. A good linearity was observed, and for protons a resolution of ±6% at 60 GeV/ c could be achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ab2c568cf897c5eb666ca082a65aab
https://doi.org/10.1016/0029-554x(74)90494-7
https://doi.org/10.1016/0029-554x(74)90494-7