Phosphoproteomics predict response to midostaurin plus chemotherapy in independent cohorts of FLT3-mutated acute myeloid leukaemiaResearch in context

Autor: Weronika E. Borek, Luis Nobre, S. Federico Pedicona, Amy E. Campbell, Josie A. Christopher, Nazrath Nawaz, David N. Perkins, Pedro Moreno-Cardoso, Janet Kelsall, Harriet R. Ferguson, Bela Patel, Paolo Gallipoli, Andrea Arruda, Alex J. Ambinder, Andrew Thompson, Andrew Williamson, Gabriel Ghiaur, Mark D. Minden, John G. Gribben, David J. Britton, Pedro R. Cutillas, Arran D. Dokal

Publikováno v: EBioMedicine, Vol 108, Iss , Pp 105316- (2024)

Summary: Background: Acute myeloid leukaemia (AML) is a bone marrow malignancy with poor prognosis. One of several treatments for AML is midostaurin combined with intensive chemotherapy (MIC), currently approved for FLT3 mutation-positive (FLT3-MP) A

Externí odkaz: https://doaj.org/article/c1ed1c39383540cb899802e9a5af0c25

Diverse model systems reveal common principles of meiosis

Autor: Weronika E. Borek, Adele L. Marston

Publikováno v: Genome Biology, Vol 19, Iss 1, Pp 1-3 (2018)

Abstract A meeting report on the 14th Gordon Research Conference on Meiosis, held at Colby Sawyer College, New London, NH, USA, 9–15 June 2018, chaired by Monica Colaiacovo, Harvard Medical School.

Externí odkaz: https://doaj.org/article/f59ecf2200b44670916b33eb17ffd73f

Deletion of Genes Encoding Arginase Improves Use of 'Heavy' Isotope-Labeled Arginine for Mass Spectrometry in Fission Yeast.

Autor: Weronika E Borek, Juan Zou, Juri Rappsilber, Kenneth E Sawin

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129548 (2015)

The use of "heavy" isotope-labeled arginine for stable isotope labeling by amino acids in cell culture (SILAC) mass spectrometry in the fission yeast Schizosaccharomyces pombe is hindered by the fact that under normal conditions, arginine is extensiv

Externí odkaz: https://doaj.org/article/0d7f2b7fe33044d18489b5fef1dd5531

The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19CCAN Complex in Meiotic Kinetochore Assembly

Autor: Juri Rappsilber, Eris Duro, Nadine Vincenten, David A. Kelly, Christos Spanos, Adele L. Marston, Flavia de Lima Alves, Weronika E. Borek, Charles L. Asbury, Vasso Makrantoni, Krishna K. Sarangapani

Publikováno v: Borek, W, Vincenten, N, Duro, E, Makrantoni, V, Spanos, C, Sarangapani, K K, de Lima Alves, F, Kelly, D, Asbury, C L, Rappsilber, J & Marston, A L 2021, ' The proteomic landscape of centromeric chromatin reveals an essential role for the Ctf19CCAN complex in meiotic kinetochore assembly ', Current Biology, vol. 31, no. 2, pp. P283-296.E7 . https://doi.org/10.1016/j.cub.2020.10.025

Kinetochores direct chromosome segregation in mitosis and meiosis. Faithful gamete formation through meiosis requires that kinetochores take on new functions that impact homolog pairing, recombination and the orientation of kinetochore attachment to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2be3b9e1f00f0953f5794eef312cac
https://doi.org/10.1016/j.cub.2020.10.025

Reductional Meiosis I Chromosome Segregation Is Established by Coordination of Key Meiotic Kinases

Autor: Stefan, Galander, Rachael E, Barton, Weronika E, Borek, Christos, Spanos, David A, Kelly, Daniel, Robertson, Juri, Rappsilber, Adèle L, Marston

Publikováno v: Developmental Cell

Summary Meiosis produces gametes through a specialized, two-step cell division, which is highly error prone in humans. Reductional meiosis I, where maternal and paternal chromosomes (homologs) segregate, is followed by equational meiosis II, where si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d91c8e064e4b3645874398eff861f937
https://pubmed.ncbi.nlm.nih.gov/31031198