Výsledky vyhledávání - "E. Blake Watkins"

Differential formation of nitrogen-centered radicals leading to unprecedented, regioselective bromination of N,N′-(1,2-phenylene)bisamides and 2-amidophenols

Autor: E. Blake Watkins, Amarender Goud Burra, Dilipkumar Uredi, Damoder Reddy Motati, J. Phillip Bowen, Frank R. Fronczek, Clint R. Smith

Publikováno v: Organic Chemistry Frontiers. 7:1095-1106

A highly efficient, site-selective, visible light-accelerated, remote C–H halogenation of unsymmetrical aromatic bisamides/amidoesters has been developed. Unprecedented selectivity was realized in this C–H functionalization reaction. The N,N′-(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da19f36b126c8dadaa4f678ea8d8c840
https://doi.org/10.1039/c9qo01508f

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Rapid Access to 3-Substituted Pyridines and Carbolines via a Domino, Copper-free, Palladium-Catalyzed Sonogashira Cross-Coupling/6π-Aza Cyclization Sequence

Autor: Dilipkumar Uredi, Amarender Goud Burra, E. Blake Watkins

Publikováno v: The Journal of organic chemistry. 86(24)

Herein, we report a one-pot, three-component method for the preparation of 3-substituted pyridines and carbolines via copper-free, palladium-catalyzed Sonogashira cross-coupling with aryl iodides, followed by 6π-aza cyclization. This arylation cross

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fe14fbde5502c87a29e087a52f10a2
https://pubmed.ncbi.nlm.nih.gov/34846892

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The Discovery and Development of Oxalamide and Pyrrole Small Molecule Inhibitors of gp120 and HIV Entry - A Review

Autor: Dilipkumar Uredi, Damoder Reddy Motati, E. Blake Watkins

Publikováno v: Current Topics in Medicinal Chemistry. 19:1650-1675

Human immunodeficiency virus type-1 (HIV-1) is the causative agent responsible for the acquired immunodeficiency syndrome (AIDS) pandemic. More than 60 million infections and 25 million deaths have occurred since AIDS was first identified in the earl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f9652030f077f65c2398892cddbe2c
https://doi.org/10.2174/1568026619666190717163959

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A simple, tandem approach to the construction of pyridine derivatives under metal-free conditions: a one-step synthesis of the monoterpene natural product, (−)-actinidine

Autor: E. Blake Watkins, Dilipkumar Uredi, Damoder Reddy Motati

Publikováno v: Chemical Communications. 55:3270-3273

A simple and modular one-step synthesis of diversely substituted pyridines from readily available α,β-unsaturated carbonyl compounds and propargylic amines has been developed. The present protocol has a broad substrate scope and allows access to mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c43a5f4562c005c10b2b2c43507580
https://doi.org/10.1039/c9cc01097a

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Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4

Autor: Amol A. Kulkarni, Ayyiliath M. Sajith, Kathy K. Griendling, M. Damoder Reddy, Qian Xu, Osman F. Güner, E. Blake Watkins, Dilbi Hussein, J. Phillip Bowen, David I. Brown, Bernard Lassègue

Publikováno v: Bioorganic & Medicinal Chemistry. 26:989-998

NADPH oxidases (Nox enzymes) are critical mediators of both physiologic and pathophysiologic processes. Nox enzymes catalyze NADPH-dependent generation of reactive oxygen species (ROS), including superoxide and hydrogen peroxide. Until recently, Nox4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa644877c37782a9dc84fdd2af54248e
https://doi.org/10.1016/j.bmc.2017.12.023

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Gram-Scale, Stereoselective Synthesis and Biological Evaluation of (+)-Armillariol C

Autor: Takumi Mori, Hirokazu Kawagishi, Hajime Kobori, E. Blake Watkins, Jing Wu, M. Damoder Reddy

Publikováno v: Journal of Natural Products. 80:2561-2565

Natural products with heteroaromatic cores are ample and widespread in nature, with many compounds exhibiting promising therapeutic properties. (+)-Armillariol C (1a) is a furan-based natural product isolated from Armillaria species. Herein, we repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d49731314b0a56e5606ddba43e01ec1
https://doi.org/10.1021/acs.jnatprod.7b00484

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Metal-catalyzed, bidentate directing group-assisted C−H functionalization: Application to the synthesis of complex natural products

Autor: Dilipkumar Uredi, Damoder Reddy Motati, E. Blake Watkins

Metal-catalyzed, bidentate directing group-assisted, C–H activation and functionalization have expanded exponentially in the past few years and provides numerous opportunities in the synthesis of a range of substrates in a straightforward and step-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe90187b1c0a48fb6e925546dfa117d7
https://doi.org/10.1016/b978-0-12-817901-7.00004-6

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Rh-Catalyzed, Regioselective, C–H Bond Functionalization: Access to Quinoline-Branched Amines and Dimers

Autor: M. Damoder Reddy, Frank R. Fronczek, E. Blake Watkins

Publikováno v: Organic Letters. 18:5620-5623

Rh-catalyzed, chelation-induced, C-5 regioselective C–H functionalization of 8-amidoquinolines with a range of N-Boc aminals is reported for the first time. The addition of in situ generated imines to C(sp2)–H bonds afforded branched amines in go

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab1ae9b5f9a8d94266361c9d2bbd8f9
https://doi.org/10.1021/acs.orglett.6b02848

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