Zobrazeno 1 - 10
of 556
pro vyhledávání: '"E. Birnbaum"'
Autor:
Ri Lu, Yan Shan Ang, Ka‐Wai Cheung, Kai Yun Quek, Wei‐Xiang Sin, Elizabeth Lee, Shir Lynn Lim, Lin‐Yue Lanry Yung, Michael E. Birnbaum, Jongyoon Han, Lih Feng Cheow, Kerwin Kwek Zeming
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Cytokines, crucial in immune modulation, impact disease progression when their secretion is dysregulated. Existing methods for profiling cytokine secretion suffer from time‐consuming and labor‐intensive processes and often fail to captur
Externí odkaz:
https://doaj.org/article/667d895d7fe443dd9e156f2e8184a4d5
Autor:
Azucena Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott, Julia Fröse, Daniel Goulet, Khloe S. Gordon, Keith P. Eidell, Paul Leclerc, Charles A. Whittaker, Rebecca C. Larson, Audrey J. Muscato, Kathleen B. Yates, Juan Dubrot, John G. Doench, Aviv Regev, Matthew G. Vander Heiden, Marcela V. Maus, Robert T. Manguso, Michael E. Birnbaum, Michael T. Hemann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of CAR-T cells and antigen escape. To investigate leukemia-intrinsic CAR-T resistance mec
Externí odkaz:
https://doaj.org/article/6711e44bcbe14aeaa34f0e56893dd8c0
Autor:
Brooke D. Huisman, Ning Guan, Timo Rückert, Lee Garner, Nishant K. Singh, Andrew J. McMichael, Geraldine M. Gillespie, Chiara Romagnani, Michael E. Birnbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune recognition. While recent studies have shown HLA-E can present diverse peptides to NK cells and T cells, the HLA-E repertoire recognized by CD94/NKG2x has re
Externí odkaz:
https://doaj.org/article/6990d2d6b3ac414787f30c599297dcd5
Autor:
Tongjin Wu, Joel Heng Loong Tan, Wei‐Xiang Sin, Yen Hoon Luah, Sue Yee Tan, Myra Goh, Michael E. Birnbaum, Qingfeng Chen, Lih Feng Cheow
Publikováno v:
Advanced Science, Vol 10, Iss 28, Pp n/a-n/a (2023)
Abstract In keeping with the rule of “form follows function”, morphological aspects of a cell can reflect its role. Here, it is shown that the cellular granularity of a lymphocyte, represented by its intrinsic side scatter (SSC), is a potent indi
Externí odkaz:
https://doaj.org/article/10d1f2d3de3b481ca65627839dfcdba7
Autor:
Kim Bich Nguyen, Malte Roerden, Christopher J Copeland, Coralie M Backlund, Nory G Klop-Packel, Tanaka Remba, Byungji Kim, Nishant K Singh, Michael E Birnbaum, Darrell J Irvine, Stefani Spranger
Publikováno v:
eLife, Vol 12 (2023)
Cancer immunotherapies, in particular checkpoint blockade immunotherapy (CBT), can induce control of cancer growth, with a fraction of patients experiencing durable responses. However, the majority of patients currently do not respond to CBT and the
Externí odkaz:
https://doaj.org/article/9322e2334e694187a616ac7046594ee7
Publikováno v:
Current Research in Ecological and Social Psychology, Vol 4, Iss , Pp 100084- (2023)
Virtual encounters are becoming increasingly frequent. These encounters have the dual potential for either posing a threat to existing relationships or promoting relationship stability. Three studies investigated whether interacting with a flirtatiou
Externí odkaz:
https://doaj.org/article/a6fa551a7ef64f18ae962f1b11efad78
Autor:
Brooke D. Huisman, Ning Guan, Timo Rückert, Lee Garner, Nishant K. Singh, Andrew J. McMichael, Geraldine M. Gillespie, Chiara Romagnani, Michael E. Birnbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/bc0cfa8840a74ebcb14c49b9fb703ab3
Publikováno v:
eLife, Vol 11 (2022)
T cells play a critical role in the adaptive immune response, recognizing peptide antigens presented on the cell surface by major histocompatibility complex (MHC) proteins. While assessing peptides for MHC binding is an important component of probing
Externí odkaz:
https://doaj.org/article/3b3a30405efb40ba9ede9aea6f8d86ee
Autor:
Beth E. Grace, Coralie M. Backlund, Duncan M. Morgan, Byong H. Kang, Nishant K. Singh, Brooke D. Huisman, C. Garrett Rappazzo, Kelly D. Moynihan, Laura Maiorino, Connor S. Dobson, Taeyoon Kyung, Khloe S. Gordon, Patrick V. Holec, Overbeck C. Takou Mbah, Daniel Garafola, Shengwei Wu, J. Christopher Love, K. Dane Wittrup, Darrell J. Irvine, Michael E. Birnbaum
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
While immune checkpoint blockade results in durable responses for some patients, many others have not experienced such benefits. These treatments rely upon reinvigorating specific T cell-antigen interactions. However, it is often unknown what antigen
Externí odkaz:
https://doaj.org/article/974ae2fd3083480d86e6565189e0552e
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Identifying peptides that can bind major histocompatibility complex II (MHC-II) is important for our understanding of T cell immunity and specificity. Here the authors present a yeast-display library screening approach that identifies more potential
Externí odkaz:
https://doaj.org/article/8de8cc1f22874ebb952282dd1b637f54