Differential Effects of Yeast NADH Dehydrogenase (Ndi1) Expression on Mitochondrial Function and Inclusion Formation in a Cell Culture Model of Sporadic Parkinson’s Disease

Autor: Emily N. Cronin-Furman, Jennifer Barber-Singh, Kristen E. Bergquist, Takao Yagi, Patricia A. Trimmer

Publikováno v: Biomolecules, Vol 9, Iss 4, p 119 (2019)

Parkinson’s disease (PD) is a neurodegenerative disorder that exhibits aberrant protein aggregation and mitochondrial dysfunction. Ndi1, the yeast mitochondrial NADH dehydrogenase (complex I) enzyme, is a single subunit, internal matrix-facing prot

Externí odkaz: https://doaj.org/article/dff8c86f4e774f288a4c74261319d47a

Contributors

Autor: Robert Abel, Ather Ali, Judith Balk, Bruce Barrett, David K. Becker, Paul E. Bergquist, Apple A. Bodemer, Robert Alan Bonakdar, Samudragupta Bora, Suhani Bora, Amy C. Brown, Remy R. Coeytaux, Stephen Dahmer, Douglas E. Dandurand, Alan M. Dattner, Brian Degenhardt, Gautam J. Desai, Stephen Devries, Dennis J. Dowling, Jeanne A. Drisko, Jeffery Dusek, Connie J. Earl, Robert Z. Edwards, Joseph Eichenseher, Ann C. Figurski, Amanda C. Filippelli, Luke Fortney, Alan R. Gaby, Louise Gagné, Paula Gardiner, Tracy Gaudet, Jeffrey Geller, Katherine Gergen-Barnett, Andrea Gordon, Russell H. Greenfield, Hana Grobel, Thomas G. Guilliams, Steven Gurgevich, Fasih A. Hameed, Adrienne Hampton, Patrick J. Hanaway, Joshua Harbaugh, John W. Harrington, James Harvie, Supriya Hayer, Michael Hernke, Michael J. Hewitt, Randy J. Horwitz, Mark Houston, Corene Humphreys, Alexandra Ilkevitch, Robert S. Ivker, Bradly Jacobs, Sarah James, Hwee Soo Jeong, Julia Jernberg, Wayne Jonas, Scott Karpowicz, Amanda J. Kaufman, David J. Kearney, Kathi J. Kemper, David Kiefer, Marcia Klein-Patel, Benjamin Kligler, Mikhail Kogan, Wendy Kohatsu, Greta J. Kuphal, Jost Langhorst, Taryn Lawler, Richard T. Lee, Roberta Lee, Russell Lemmon, David M. Lessens, Sanford H. Levy, Edward (Lev) Linkner, Natalia O. Litbarg, Yue Man Onna Lo, Amy B. Locke, Abigail Love, Tieraona Low Dog, Junelle H. Lupiani, Victoria Maizes, D. Jill Mallory, John Douglas Mann, Lucille R. Marchand, John D. Mark, Michelle E. Martinez, Richard McKinney, Michelle J. Mertz, Aaron J. Michelfelder, Vincent J. Minichiello, Matthew Moher, Daniel Muller, Gerard E. Mullin, Sarah A. Murphy, Harmon Myers, Rubin Naiman, Kaushal Nanavati, James P. Nicolai, Bobby Nourani, Brian Olshansky, Sunil T. Pai, Alyssa M. Parian, Adam I. Perlman, Surya Pierce, Gregory A. Plotnikoff, Rian Podein, David Rabago, David Rakel, Jacqueline Redmer, Eric Reed, Robert Rhode, J. Adam Rindfleisch, Melinda Ring, Eric J. Roseen, Lisa Rosenberger, Maret Rossi, Martin L. Rossman, Pooja Saigal, Bonnie R. Sakallaris, Anju Sawni, Craig Schneider, Howard Schubiner, Nancy J. Selfridge, Tanmeet Sethi, Adam D. Simmons, Tracy L. Simpson, Coleen Smith, Myles Spar, Srivani Sridhar, Tina M. St. John, James A. Stewart, Larry Stoler, Nancy L. Sudak, Jonathan Takahashi, Leslie Mendoza Temple, Malynn L. Utzinger, Donald Warne, Allan Warshowsky, Michael J. Weber, Andrew Weil, Joy A. Weydert, Myrtle Wilhite, Theodore Wissink, Andrew J. Wolf, Daniel Wolpert, Jimmy Wu, Aleksandra Zgierska

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1f74f4f23112da0d8f000537daaec7e
https://doi.org/10.1016/b978-0-323-35868-2.01002-1

Mitochondrial Gene Therapy Augments Mitochondrial Physiology in a Parkinson's Disease Cell Model

Autor: Kristen E. Bergquist, Kathleen M. Schwarz, Patricia A. Trimmer, Shilpa Iyer, Ravindar R. Thomas, Christina M. Papageorge, James P. Bennett, Shaharyar M. Khan, Lisa D. Dunham, Caitlin K. Quigley, Paula M. Keeney, Francisco R. Portell

Publikováno v: Human Gene Therapy. 20:897-907

Neurodegeneration in Parkinson's disease (PD) affects mainly dopaminergic neurons in the substantia nigra, where age-related, increasing percentages of cells lose detectable respiratory activity associated with depletion of intact mitochondrial DNA (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550675f8d4111707ff0569aa964c0aa6
https://doi.org/10.1089/hum.2009.023

Total knee arthroplasty in an adult with congenital dislocation of the patella

Autor: Henry A. Finn, Patricia A. Baumann, Peter E. Bergquist

Publikováno v: The Journal of Arthroplasty. 16:384-388

This article reports the use of total knee arthroplasty with release of the lateral retinaculum, proximal extensor mechanism realignment, and patellar resurfacing as a valid treatment option for adult patients with congenital dislocation of the patel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2708cbbe1fcb1ab49bf61edc7d22468b
https://doi.org/10.1054/arth.2001.20545

Mitochondrial gene therapy improves respiration, biogenesis, and transcription in G11778A Leber's hereditary optic neuropathy and T8993G Leigh's syndrome cells

Autor: Shilpa Iyer, Raj R. Rao, James P. Bennett, Erich Gnaiger, Kisha J. Young, Kristen E. Bergquist

Publikováno v: Human gene therapy. 23(6)

Many incurable mitochondrial disorders result from mutant mitochondrial DNA (mtDNA) and impaired respiration. Leigh's syndrome (LS) is a fatal neurodegenerative disorder of infants, and Leber's hereditary optic neuropathy (LHON) causes blindness in y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c211b02af162986a8f328a14dd69c69c
https://pubmed.ncbi.nlm.nih.gov/22390282