Výsledky vyhledávání - "E. B. Smalstig"

Dopamine agonist activities of pergolide, its metabolites, and bromocriptine as measured by prolactin inhibition, compulsive turning, and stereotypic behavior

Autor: J A, Clemens, T, Okimura, E B, Smalstig

Publikováno v: Arzneimittel-Forschung. 43(3)

Four pergolide metabolites and bromocriptine (CAS 25614-03-3) were compared to pergolide (8 beta-[(methylthio) methyl]-6-propyl-ergoline, CAS 66104-22-1) using three in vivo animal models of activity at dopamine receptors. The results obtained from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::255d4349f798269960528cf15c7e24b8
https://pubmed.ncbi.nlm.nih.gov/8489554

Zobrazit plný text záznamu

Progress in the medicinal chemistry of dopaminergic agents

Autor: J M, Schaus, E C, Kornfeld, R D, Titus, C L, Nichols, D L, Huser, J A, Clemens, E B, Smalstig, R W, Fuller

Publikováno v: Drug design and discovery. 9(3-4)

Ergot alkaloids and their derivatives have long been recognized for their potent pharmacologic activity. A number of ergot derivatives, including the dopamine agonists bromocriptine and pergolide, are currently in clinical use for the treatment of CN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf71bd433f1388d5737df81bf2b2e19b
https://pubmed.ncbi.nlm.nih.gov/8104521

Zobrazit plný text záznamu

A phenothiazine derivative reduces rat brain damage after global or focal ischemia

Autor: Michael E. Roush, E B Smalstig, J R McCowan, M J Yu, D R Bennett, James A. Clemens

Publikováno v: Stroke. 23(9)

We previously reported that 2-(10H-phenothiazin-2-yloxy)-N,N-dimethylethanamine hydrochloride is a potent inhibitor of iron-dependent lipid peroxidation in vitro and can protect primary cultures of rat hippocampal neurons from hydrogen peroxide-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d409a4fa507db284753dd7ceb1012a1
https://pubmed.ncbi.nlm.nih.gov/1519284

Zobrazit plný text záznamu

ChemInform Abstract: Synthesis and Evaluation of N,N-Di(n-propyl)tetrahydrobenz(f)indol-7-amine and Related Congeners as Dopaminergic Agonists

Autor: J. A. Clemens, P. E. Persons, David E. Nichols, E. B. Smalstig, John M. Cassady, M. C. Yeung

Publikováno v: ChemInform. 21

The dopaminergic activity of the indole (VII), the tetrahydrobenzindole (XIX), and of the related compounds (IX) and (XXI), synthesized as shown in the reaction scheme, is evaluated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa35cc3365a82722b5f2ed90e0f9b8b3
https://doi.org/10.1002/chin.199008144

Zobrazit plný text záznamu

Resolution and absolute configuration of an ergoline-related dopamine agonist, trans-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H(or 2H)-pyrazolo[3,4-g]quinoline

Autor: Ray W. Fuller, Norman R. Mason, Robert Daniel Titus, Hynes, Hahn Ra, Kornfeld Edmund C, E. B. Smalstig, Foreman Mark Mortensen, David T.W. Wong, Noel D. Jones, James A. Clemens

Publikováno v: Journal of Medicinal Chemistry. 26:1112-1116

The title compound (+/-)-5 (R = Pro) (LY141865) has been resolved into a (-) isomer and a (+) isomer as the D- and L-tartrate salts, respectively. Biological studies have shown that dopamine agonist activity is a property of only the (-) isomer. Crys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b3df3a35d95f8a1a15b899ab11af60
https://doi.org/10.1021/jm00362a005

Zobrazit plný text záznamu

Effects of Corpus Luteum Removal on Ovarian Cyclicity of the Rat

Autor: Carl Joseph Shaar, E. B. Smalstig, R. L. Cochrane, D. R. Bennett

Publikováno v: Endocrinology. 89:714-721

The effect of corpora lutea removal (CLR) and sham operations (SO) performed on different days of the estrous cycle and pseudopregnancy was studied in the rat. SO and CLR in cyclic rats had little or no effect on the operation cycle or the 2 subseque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dbe6f71e7945404834234ee83605337
https://doi.org/10.1210/endo-89-3-714

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání