Zobrazeno 1 - 10
of 79
pro vyhledávání: '"E. Augelli"'
Autor:
Ana Catya Jiménez-Torres, Katherine D. Porter, Jamison A. Hastie, Charles Adeniran, Omar Moukha-Chafiq, Theresa H. Nguyen, Subramaniam Ananthan, Corinne E. Augelli-Szafran, Chang-Guo Zhan, Jun Zhu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7881 (2024)
Prolonged exposure to HIV-1 transactivator of transcription (Tat) protein dysregulates monoamine transmission, a physiological change implicated as a key factor in promoting neurocognitive disorders among people living with HIV. We have demonstrated
Externí odkaz:
https://doaj.org/article/5cc42e605e36436483d5900c34f976a5
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination assoc
Externí odkaz:
https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c
Autor:
Catherine J Libby, Sajina Gc, Gloria A. Benavides, Jennifer L. Fisher, Sarah E. Williford, Sixue Zhang, Anh Nhat Tran, Emily R. Gordon, Amber B. Jones, Kaysaw Tuy, William Flavahan, Juan Gordillo, Ashlee Long, Sara J. Cooper, Brittany N. Lasseigne, Corinne E. Augelli-Szafran, Victor Darley-Usmar, Anita B. Hjelmeland
Publikováno v:
Cell Adhesion & Migration, Vol 15, Iss 1, Pp 101-115 (2021)
The multifaceted roles of metabolism in invasion have been investigated across many cancers. The brain tumor glioblastoma (GBM) is a highly invasive and metabolically plastic tumor with an inevitable recurrence. The neuronal glucose transporter 3 (GL
Externí odkaz:
https://doaj.org/article/8ae81f05eb1749278b5439e70c0972a8
Autor:
Gelare Ghajar-Rahimi, Amie M. Traylor, Bini Mathew, James R. Bostwick, N Miranda Nebane, Anna A. Zmijewska, Stephanie K. Esman, Saakshi Thukral, Ling Zhai, Vijaya Sambandam, Rita M. Cowell, Mark J. Suto, James F. George, Corinne E. Augelli-Szafran, Anupam Agarwal
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1888 (2022)
Acute kidney injury (AKI) is a major public health concern with significant morbidity and mortality and no current treatments beyond supportive care and dialysis. Preclinical studies have suggested that heme-oxygenase-1 (HO-1), an enzyme that catalyz
Externí odkaz:
https://doaj.org/article/25f0f94d8f124a2fac06bb9aa63b0b1c
Autor:
Sixue Zhang, Atefeh Garzan, Nicole Haese, Robert Bostwick, Yohanka Martinez-Gzegozewska, Lynn Rasmussen, Daniel N Streblow, Mark T Haise, Ashish K Pathak, Corinne E Augelli-Szafran, Mousheng Wu
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245013 (2021)
The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence. No small molecule drugs targeting CHIKV nsP3 have
Externí odkaz:
https://doaj.org/article/952fb40efdab473d99e7cb134f2a7cbb
Autor:
Carolyn A. Robinson, Terri D. Lyddon, Hwi Min Gil, David T. Evans, Yury V. Kuzmichev, Jonathan Richard, Andrés Finzi, Sarah Welbourn, Lynn Rasmussen, N. Miranda Nebane, Vandana V. Gupta, Sam Ananthan, Zhaohui Cai, Elizabeth R. Wonderlich, Corinne E. Augelli-Szafran, Robert Bostwick, Roger G. Ptak, Susan M. Schader, Marc C. Johnson
Publikováno v:
Viruses, Vol 14, Iss 4, p 817 (2022)
HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate
Externí odkaz:
https://doaj.org/article/cb9aa0928f724cc5b71172c99af2a758
Autor:
Parthasaradhireddy Tanguturi, Vibha Pathak, Sixue Zhang, Omar Moukha-Chafiq, Corinne E. Augelli-Szafran, John M. Streicher
Publikováno v:
Molecules, Vol 27, Iss 6, p 1969 (2022)
There was an error in the original publication [...]
Externí odkaz:
https://doaj.org/article/54902c0637114ec39b5db4ec633e321b
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 384:306-314
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bde665094ead298d6511deda35921902
https://doi.org/10.1124/jpet.122.001291
https://doi.org/10.1124/jpet.122.001291
Autor:
Parthasaradhireddy Tanguturi, Vibha Pathak, Sixue Zhang, Omar Moukha-Chafiq, Corinne E. Augelli-Szafran, John M. Streicher
Publikováno v:
Molecules, Vol 26, Iss 21, p 6693 (2021)
The delta opioid receptor (DOR) is a crucial receptor system that regulates pain, mood, anxiety, and similar mental states. DOR agonists, such as SNC80, and DOR-neutral antagonists, such as naltrindole, were developed to investigate the DOR in vivo a
Externí odkaz:
https://doaj.org/article/b9531487f7ba4d92a97a741674b91326
Autor:
Schneider, Catherine E. Scull, Guy Twa, Yinfeng Zhang, Naiheng J. Yang, Robert N. Hunter, Corinne E. Augelli-Szafran, David A.
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3303
Cancer cells are especially sensitive to perturbations in ribosome biogenesis as they rely on finely tuned protein homeostasis to facilitate their rapid growth and proliferation. While ribosome synthesis and cancer have a well-established relationshi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::68088956c07b93ab00435f0b42d7d292