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Akademický článek

SABRes: in silico detection of drug resistance conferring mutations in subpopulations of SARS-CoV-2 genomes

Autor: Winkie Fong, Rebecca J. Rockett, Jessica E. Agius, Shona Chandra, Jessica Johnson-Mckinnon, Eby Sim, Connie Lam, Alicia Arnott, Mailie Gall, Jenny Draper, Susan Maddocks, Sharon Chen, Jen Kok, Dominic Dwyer, Matthew O’Sullivan, Vitali Sintchenko

Publikováno v: BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-7 (2023)

Abstract The emergence of resistance to antiviral drugs increasingly used to treat SARS-CoV-2 infections has been recognised as a significant threat to COVID-19 control. In addition, some SARS-CoV-2 variants of concern appear to be intrinsically resi

Externí odkaz: https://doaj.org/article/4fc407e2a2984577978554c2ee02e675

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Akademický článek

Co-infection with SARS-CoV-2 Omicron and Delta variants revealed by genomic surveillance

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)

Here, using genomic approaches, Rockett et al. identify Omicron and Delta SARS-CoV-2 co-infections in two adults, highlighting the usefulness of genomic surveillance for the timely recognition of co-infections in situations when different variants of

Externí odkaz: https://doaj.org/article/38f87202ab14461b82215251ef687d21

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Akademický článek

Experimental infection of Asian house geckos with Enterococcus lacertideformus demonstrates multiple disease transmission routes and the in-vivo efficacy of antibiotics

Autor: Jessica E. Agius, Karrie Rose, Jon-Paul Emery, David N. Phalen

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract The disease caused by Enterococcus lacertideformus is multisystemic and ultimately fatal. Since its emergence, the bacterium has significantly impacted the captive breeding programs of the extinct in the wild Christmas Island Lister’s geck

Externí odkaz: https://doaj.org/article/be3c61866be44fce924b0ee2d35cba52

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Akademický článek

SARS-CoV-2 Within-Host and in vitro Genomic Variability and Sub-Genomic RNA Levels Indicate Differences in Viral Expression Between Clinical Cohorts and in vitro Culture

Autor: Jessica E. Agius, Jessica C. Johnson-Mackinnon, Winkie Fong, Mailie Gall, Connie Lam, Kerri Basile, Jen Kok, Alicia Arnott, Vitali Sintchenko, Rebecca J. Rockett

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

BackgroundLow frequency intrahost single nucleotide variants (iSNVs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been increasingly recognised as predictive indicators of positive selection. Particularly as growing numbers of

Externí odkaz: https://doaj.org/article/9e3cfd6308464cbe9868341a704089b8

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Akademický článek

Improved Neutralisation of the SARS-CoV-2 Omicron Variant following a Booster Dose of Pfizer-BioNTech (BNT162b2) COVID-19 Vaccine

Autor: Kerri Basile, Rebecca J. Rockett, Kenneth McPhie, Michael Fennell, Jessica Johnson-Mackinnon, Jessica E. Agius, Winkie Fong, Hossinur Rahman, Danny Ko, Linda Donavan, Linda Hueston, Connie Lam, Alicia Arnott, Sharon C.-A. Chen, Susan Maddocks, Matthew V. O’Sullivan, Dominic E. Dwyer, Vitali Sintchenko, Jen Kok

Publikováno v: Viruses, Vol 14, Iss 9, p 2023 (2022)

In late November 2021, the World Health Organization declared the SARS-CoV-2 lineage B.1.1.529 the fifth variant of concern, Omicron. This variant has acquired over 30 mutations in the spike protein (with 15 in the receptor-binding domain), raising c

Externí odkaz: https://doaj.org/article/8dda37bba9e34d4c9c7bf42985c2af33

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Akademický článek

Pharmacokinetic profile of enrofloxacin and its metabolite ciprofloxacin in Asian house geckos (Hemidactylus frenatus) after single-dose oral administration of enrofloxacin

Autor: Jessica E. Agius, Benjamin Kimble, Merran Govendir, Karrie Rose, Charley-Lea Pollard, David N. Phalen

Publikováno v: Veterinary and Animal Science, Vol 9, Iss , Pp 100116- (2020)

The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were determined following oral administration in 21 Asian house geckos (Hemidactylus frenatus) at a dose of 10 mg/kg. Changes in enrofloxacin and ciprofloxacin plasma concen

Externí odkaz: https://doaj.org/article/36f92397aa8a4b9abccea5cf5a69fdd1

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