Zobrazeno 1 - 10
of 97
pro vyhledávání: '"E. A. Timina"'
Publikováno v:
Bulletin of Experimental Biology and Medicine. 143:64-67
Parameters of peripheral blood in female rats remained practically unchanged at late terms after single treatment with antitumor drug etoposise. Pregnancy was accompanied by the development of reversible regeneration anemia. Proliferative activity of
Publikováno v:
Bulletin of Experimental Biology and Medicine. 127:33-36
The morphological signs of apoptosis in the bone-marrow cells and thymocytes, indices of cellularity in these organs and in peripheral blood and the absolute number of committed bone marrow cells-precursors have been studied on CBA mice injected with
Autor:
E. A. Timina, Yu. A. Shchemerova, A. V. Pakhomova, T. G. Borovskaya, V. E. Gol’dberg, A. V. Perova
Publikováno v:
Bulletin of Experimental Biology and Medicine. 143:614-616
The possibility of reducing the ovariotoxicity of antitumor drug etoposide with buserelin, a hypothalamic regulator of pituitary function, was studied in female Wistar rats. Quantitative analysis of ovarian structural and functional elements on seria
Publikováno v:
Bulletin of Experimental Biology and Medicine. 143:61-63
Antitumor drug paclitaxel administered in MTD to female rats 1, 3, and 6 months before mating with intact males had a toxic effect on the progeny. We observed increased anteand postnatal mortality, decelerated physical development, low rate of format
Publikováno v:
Bulletin of Experimental Biology and Medicine. 143:18-20
The morphology and function of the ovaries at the early and late terms after single intravenous injection of paclitaxel in the maximum tolerated dose (MTD) were studied in female Wistar rats. Evaluation of the structural and functional elements of th
Publikováno v:
Bulletin of Experimental Biology and Medicine. 141:645-647
Morphological and functional state of the ovaries in female Wistar rats was assessed in the early and late periods after administration of antitumor drug vepesid in a single maximum tolerated dose. In the early period, the drug pronouncedly decreased
Publikováno v:
Bulletin of Experimental Biology and Medicine. 124:1194-1197
Stable morphological changes and disorders of spermatogenesis develop in the testicles of Wistar rats during 30 days after a single injection of vepeside in the maximum tolerance dose. By the end of experiment the morphology of the testicles graduall
Autor:
E. A. Timina, M. V. Zavjalova, V. M. Perelmuter, S. V. Vtorushin, T. G. Borovskaja, T. I. Fomina
Publikováno v:
Bulletin of experimental biology and medicine. 144(5)
Intravenous injection of antitumor drug etoposide in the maximum tolerated dose was followed by the development of breast cancer in 38.1% female Wistar rats and 6.7% female outbred mice.
Autor:
G V, Karpov, T I, Fomina, O L, Voronova, E V, Abramova, E A, Timina, T Iu, Lamzina, L A, Ermolaeva, A V, Perova
Publikováno v:
Eksperimental'naia i klinicheskaia farmakologiia. 70(4)
Paclitaxel (single intravenous injection in a maximum tolerated dose of 4.6 mg/kg) to white outbred rats causes bone marrow hypoplasia, increased granulocyte and erythroid cell mitosis (metaphase-anaphase transition), and moderate pancytopenia develo
Autor:
V. E. Gol’dberg, Yu. A. Shchemerova, A. V. Perova, E. A. Timina, M. E. Poluektova, T. G. Borovskaya
Publikováno v:
Bulletin of experimental biology and medicine. 140(3)
Experiments on adult rats showed that a single intravenous injection of antitumor drug vepeside in a MTD (maximum tolerable dose) reduced the reproductive status during periods corresponding to exposure of mature sex cells, spermatocytes, and spermat