Zobrazeno 1 - 10
of 64
pro vyhledávání: '"E. A. Stepovaya"'
Autor:
O. L. Nosareva, E. A. Stepovaya
Publikováno v:
Медицинская иммунология, Vol 26, Iss 4, Pp 671-676 (2024)
Lymphocytes are key cells in inflammation. The realization of inflammation accompanied by the development of oxidative stress depends on metabolic processes occurring in blood lymphocytes. Experimental studies of molecular control of the redox status
Externí odkaz:
https://doaj.org/article/32856bdb24a548c498fa90131f0e5349
Autor:
A. P. Pomogaeva, O. L. Nosareva, E. A. Stepovaya, T. V. Zhavoronok, E. V. Shakhristova, E. I. Krasnova, A. V. Vasyunin
Publikováno v:
Журнал инфектологии, Vol 12, Iss 5, Pp 130-137 (2021)
The objective is to compare clinical symptoms, lipid peroxidation indicators, the state of the antioxidant system and assess their impact on the severity and progression of pseudotuberculosis in children.Materials and methods. We examined 125 childre
Externí odkaz:
https://doaj.org/article/e8a0fde5fe514ae2bbcf7dd9ed576fab
Publikováno v:
Бюллетень сибирской медицины, Vol 19, Iss 2, Pp 72-77 (2020)
Relevance. Impairment of apoptosis regulation in P19 cells is correlated with generation of oxidative stress. Under hypoxia, changes in mitochondrial functions occur, which may exacerbate oxidative stress in the tumor cell. The aim of the study was t
Externí odkaz:
https://doaj.org/article/c827426e70c84b519711ea51f83266d8
Publikováno v:
Сибирский онкологический журнал, Vol 19, Iss 3, Pp 102-108 (2020)
Introduction. Hypoxia in tumor growth contributes to mitochondrial dysfunction and exacerbates oxidative stress in the immortalized cell. The objective of the study was to investigate the molecular mechanisms of the effects of N-acetylcysteine on red
Externí odkaz:
https://doaj.org/article/eb381077d09a43c18cff351304c01a1b
Publikováno v:
Сибирский онкологический журнал, Vol 17, Iss 6, Pp 78-83 (2019)
Introduction. High rates of cancer incidence and mortality worldwide dictate the necessity of developing new methodological approaches in understanding the molecular mechanisms of cancer progression associated with intracellular redox regulation imba
Externí odkaz:
https://doaj.org/article/2bd6f30312a84d0d888d1a3ad8e9aee6
Autor:
E. V. Shakhristova, E. A. Stepovaya, O. L. Nosareva, L. S. Litvinova, D. A. Skuratovskaya, E. V. Rudikov, A. A. Sadykova, V. V. Novitsky
Publikováno v:
Бюллетень сибирской медицины, Vol 17, Iss 4, Pp 180-186 (2018)
Redox proteins (thioredoxin, glutaredoxin) are key macromolecules capable of modulating intracellular processes. This determines research choices in the field of redox-dependent cell proliferation management. The study of the molecular mechanisms of
Externí odkaz:
https://doaj.org/article/fa7bf85606374c2ca112d148581ffe64
Autor:
O. L. Nosareva, E. A. Stepovaya, N. V. Ryazantseva, E. V. Shakhristova, D. S. Orlov, V. V. Novitsky
Publikováno v:
Бюллетень сибирской медицины, Vol 17, Iss 3, Pp 96-104 (2018)
Introduction. One of the crucial tasks in medicine is studying the molecular mechanisms of selective management of tumor cell apoptosis following conformational changes in protein molecules (ubiquitination).The purpose of the study. The aim of the pr
Externí odkaz:
https://doaj.org/article/f4a42d17d2304e218dfc8192dc37489d
Autor:
V. V. Ivanov, E. V. Shakhristova, E. A. Stepovaya, N. V. Litvjakov, N. A. Perekucha, O. L. Nosareva, T. S. Fedorova, V. V. Novitsky
Publikováno v:
Бюллетень сибирской медицины, Vol 16, Iss 4, Pp 134-143 (2018)
Rationale. According to modern understanding, oxidative stress plays an essential role in the underlying mechanisms for the emergence of type 1 and type 2 diabetes and development of complications in these conditions. The sources of reactive oxygen s
Externí odkaz:
https://doaj.org/article/dd895b95c1684670852c734864822cba
Autor:
D. S. Orlov, N. V. Ryazantseva, E. A. Stepovaya, O. L. Nosareva, E. V. Shakhristova, V. V. Ivanov
Publikováno v:
Сибирский онкологический журнал, Vol 15, Iss 6, Pp 42-47 (2016)
Introduction. Changes in the redox status of tumor cells can be used as one of the molecular mechanisms of apoptosis aimed at increasing the susceptibility of tumor cells to chemotherapeutic agents. Purpose: to study the mechanisms of dysregulation o
Externí odkaz:
https://doaj.org/article/79e1dcb2517444379fdcc3145835aec1
Autor:
E. A. Stepovaya, E. V. Shakhristova, N. V. Ryazantseva, O. L. Nosareva, R. I. Chil’chigashev, M. Yu. Egorova
Publikováno v:
Сибирский онкологический журнал, Vol 15, Iss 4, Pp 50-55 (2016)
Introduction. Despite the available data on tumor cell functioning under the conditions of free radical-mediated oxidation, the mechanisms of redox regulation, cell proliferation management and apoptosis avoidance remain understudied.The objective of
Externí odkaz:
https://doaj.org/article/c38111637f984c3aa09f44208fee5ea5