Zobrazeno 1 - 10
of 13
pro vyhledávání: '"E. A. Saville‐Stones"'
Publikováno v:
Tetrahedron. 53:14481-14496
A method for achieving the sequential functionalisation of the imidazole ring in the order C-5→C-4→C-2 is described. The chemistry proceeds via the regioselective formation of positionally stable imidazolyl anions which are reacted with electroph
Autor:
E. A. Saville‐Stones, O'mahony Mary Josephine, Michael Kilkelly, Mark J. Ford, Stephen D. Lindell, Jane E. Dancer, Kenneth Hamilton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2131-2136
Novel inhibitors of histidinol dehydrogenase are described. The most potent inhibitors, compounds 18 ( F i ∗ = 4.4 nM) and 19 ( K i ∗ = 2.9 nM) exploit a hitherto unreported lipophilic binding pocket adjoining the active site. Preliminary SAR dat
Autor:
E. A. Saville‐Stones, Stephen D. Lindell, Brian John Wright, David S. Carver, Christopher G. Earnshaw, O'mahony Mary Josephine
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:547-552
Novel inhibitors of the newly discovered herbicide target enzyme imidazole glycerol phosphate dehydratase are described. The most potent inhibitor, compound 6 (IC50
Autor:
E. A. Saville‐Stones, J. C. Head, David S. Carver, N. S. Jennings, Stephen D. Lindell, Richard M. Turner
Publikováno v:
Tetrahedron. 50:6695-6704
Four carbocyclic analogues of the ribonucleoside coformycin, including the recently isolated natural product 2, have been synthesised in racemic form. The syntheses were achieved in a convergent and direct manner via palladium(0) catalysed coupling b
Publikováno v:
ChemInform. 23
Publikováno v:
ChemInform. 23
Autor:
E. A. Saville‐Stones, N. S. Jennings, David S. Carver, Richard M. Turner, Stephen D. Lindell, J. C. Head
Publikováno v:
ChemInform. 25
Four carbocyclic analogues of the ribonucleoside coformycin, including the recently isolated natural product 2, have been synthesised in racemic form. The syntheses were achieved in a convergent and direct manner via palladium(0) catalysed coupling b
Autor:
Christopher G. Earnshaw, E. A. Saville‐Stones, Stephen D. Lindell, David S. Carver, O'mahony Mary Josephine, Brian John Wright
Publikováno v:
ChemInform. 27
Novel inhibitors of the newly discovered herbicide target enzyme imidazole glycerol phosphate dehydratase are described. The most potent inhibitor, compound 6 (IC50
Autor:
O'mahony Mary Josephine, Kenneth Hamilton, Michael Kilkelly, Mark J. Ford, E. A. Saville‐Stones, Stephen D. Lindell, Jane E. Dancer
Publikováno v:
ChemInform. 27
Novel inhibitors of histidinol dehydrogenase are described. The most potent inhibitors, compounds 18 ( F i ∗ = 4.4 nM) and 19 ( K i ∗ = 2.9 nM) exploit a hitherto unreported lipophilic binding pocket adjoining the active site. Preliminary SAR dat
Publikováno v:
ChemInform. 29