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Autor: E J, Neale, A M, Chang

Publikováno v: Medical Teacher. 13:317-322

Clinical flow charts or algorithms are becoming an increasingly popular means of summarizing the management of a given clinical situation. However they vary greatly in complexity between authors, making comparisons difficult, and detracting from thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e53348b3a95b040f94f7594f8548c6
https://doi.org/10.3109/01421599109089912

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Cloning and expression of functional fragment C of tetanus toxin

Autor: J L Halpern, E. A. Neale, Scott Stibitz, W H Habig

Publikováno v: Infection and Immunity. 58:1004-1009

A segment of Clostridium tetani DNA corresponding to fragment C of tetanus toxin was amplified by using the polymerase chain reaction. This fragment was cloned into expression vector pTTQ8, under the control of the tac promoter. Expression of this pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a90f0a942165c6cfff49940680239cb
https://doi.org/10.1128/iai.58.4.1004-1009.1990

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Persistence of botulinum neurotoxin action in cultured spinal cord cells

Autor: J E, Keller, E A, Neale, G, Oyler, M, Adler

Publikováno v: FEBS letters. 456(1)

Primary dissociated fetal mouse spinal cord cultures were used to study the mechanisms underlying the differences in persistence of botulinum neurotoxin A (BoNT/A) and botulinum neurotoxin/E (BoNT/E) activities. Spinal cord cultures were exposed to B

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https://pubmed.ncbi.nlm.nih.gov/10452545

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Women's satisfaction with medical termination

Autor: M E, Maaita, C, Prasarman, J, Smith, E J, Neale

Publikováno v: The British journal of family planning. 25(1)

One hundred women aged between 14 and 43 completed a questionnaire regarding their experience and satisfaction with medical termination of pregnancy at Bedford Hospital. A visual analogue score from 0-10 was used. Age, occupation, marital status, par

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https://pubmed.ncbi.nlm.nih.gov/10228242

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Clostridial neurotoxins and substrate proteolysis in intact neurons: botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa

Autor: L C, Williamson, J L, Halpern, C, Montecucco, J E, Brown, E A, Neale

Publikováno v: The Journal of biological chemistry. 271(13)

Clostridial neurotoxins are zinc endopeptidases that block neurotransmission and have been shown to cleave, in vitro, specific proteins involved in synaptic vesicle docking and/or fusion. We have used immunohistochemistry and immunoblotting to demons

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https://pubmed.ncbi.nlm.nih.gov/8631808

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Neurospecific Binding, Internalization, and Retrograde Axonal Transport

Autor: J. L. Halpern, E. A. Neale

Publikováno v: Current Topics in Microbiology and Immunology ISBN: 9783642851759

A number of pharmacologic agents which act on intracellular targets typically bind to specific cell surface receptors and are internalized in order to exert their effects on a cytosolic substrate (Neville and Chang 1978). Although many of the details

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https://doi.org/10.1007/978-3-642-85173-5_10

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