Zobrazeno 1 - 10
of 10
pro vyhledávání: '"E. A. M. Seeds"'
Autor:
Mike B. Comer, E. A. M. Seeds, Clive P. Page, Alec W. Oxford, Domenico Spina, Victoria Boswell-Smith
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 318:840-848
The pharmacology of two novel, trequinsin-like PDE3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-( N -carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2 H -pyrimido-[6,1- a ]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6dcd06f56ffc57d485014c57101918
https://doi.org/10.1124/jpet.105.099192
https://doi.org/10.1124/jpet.105.099192
Publikováno v:
British Journal of Pharmacology. 107:653-659
1 We examined effects of bradykinin (BK) receptor antagonists on airway hyperresponsiveness and eosinophilia in sensitized guinea-pigs that had been administered single, as well as repeated (chronic) challenges with inhaled ovalbumin. In addition, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197314be8b5261e3322df08f3e0d4726
https://doi.org/10.1111/j.1476-5381.1992.tb14502.x
https://doi.org/10.1111/j.1476-5381.1992.tb14502.x
Autor:
Donald J. Kyle, Yakov Rotshteyn, E. A. M. Seeds, Clive P. Page, Gary Douglas, Perry V. Halushka, Mark Chasin, Donna Donigi Gale, Tatsui Matsumoto, David Cavalla, Ronald M. Burch, Katherine H Banner, Nandini Banik, Domenico Spina, Forrest L. Smith, Richard H. Wong, Selina Harrison, Peter Hofer, Stephan Jordan
Publikováno v:
Pulmonary pharmacologytherapeutics. 16(2)
V11294 is a new cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor of the rolipram class. In this report we present the pharmacological profile of V11294. V11294 inhibited PDE4 isolated from human lung with IC 50 405 nM, compared to 3700 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321edc1df35435caec0a27fa42c6fc75
https://pubmed.ncbi.nlm.nih.gov/12670778
https://pubmed.ncbi.nlm.nih.gov/12670778
Autor:
E. A. M. Seeds, Clive P. Page
Publikováno v:
Pulmonary pharmacologytherapeutics. 14(2)
There is considerable interest in the discovery of novel molecules for the treatment of allergic diseases and several recent studies have demonstrated that heparin can inhibit airway responses in subjects with asthma. However, heparin is also an anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb35b2fa16cac33a8f0875e803de02dc
https://pubmed.ncbi.nlm.nih.gov/11273792
https://pubmed.ncbi.nlm.nih.gov/11273792
Publikováno v:
Pulmonary pharmacologytherapeutics. 12(1)
The racemic mixture propranolol (RS-(+/-)-, and the S-(-)- and R-(+)-) isomers of propranolol have been shown to induce bronchial hyperresponsiveness in the guinea-pig unrelated to beta-adrenoreceptor occupancy, that is attenuated by vagal section an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1f2070ceb1015824852538623ac554
https://pubmed.ncbi.nlm.nih.gov/10208833
https://pubmed.ncbi.nlm.nih.gov/10208833
Publikováno v:
European journal of pharmacology. 293(4)
The effect of a novel leukotriene B 4 receptor antagonist N -[5-[[8-(1-hydroxy-2-phenyl)ethyl]dibenzofuran-2-yl]-5-hydroxypentanoyl] pyrrolidine (PF 10042) has been evaluated in comparison with 2-[3-(1-hydroxyhexyl)phenoxymethyl]quinoline hydrochlori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da28a3902b91e7a61e93cb35f5d6bc7
https://pubmed.ncbi.nlm.nih.gov/8748690
https://pubmed.ncbi.nlm.nih.gov/8748690
Autor:
C. M. Herd, G J Douglas, Clive P. Page, E. A. M. Seeds, D. Spina, Maggie M. Riccio, M.G. McKenniff, Eleanor M. Minshall, Masahiro Sasaki
Publikováno v:
Journal of pharmacological and toxicological methods. 30(4)
The present study investigates the development and maintenance of airway hyperresponsiveness in neonatally immunized rabbits. Rabbits were immunized within 24 hr of birth with the antigen Alternaria tenuis together with aluminum hydroxide as an adjuv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96f29ea816f7289644f1a14073c6a63
https://pubmed.ncbi.nlm.nih.gov/8123899
https://pubmed.ncbi.nlm.nih.gov/8123899
Autor:
Francesca Perretti, Stefano Evangelista, Luigi Abelli, Clive P. Page, Stefano Manzini, E. A. M. Seeds
Publikováno v:
European journal of pharmacology. 249(3)
The pharmacological actions of the new xanthine, isbufylline, were evaluated in several models of airway hyperresponsiveness and airway inflammation in guinea pigs. At a dose (106 μmol kg −1 i.p.) providing complete protection against acetylcholin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1338ec12acbdcc1f58660585fcecb822
https://pubmed.ncbi.nlm.nih.gov/7507057
https://pubmed.ncbi.nlm.nih.gov/7507057
Publikováno v:
European Journal of Pharmacology. 183:1131
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc5192aa053fd283eff77955b39c65a
https://doi.org/10.1016/0014-2999(90)94216-k
https://doi.org/10.1016/0014-2999(90)94216-k
Autor:
Francesca Perretti, Clive P. Page, Manuela Tramontana, A.J. Coyle, Stefano Manzini, D. Spina, M.G. McKenniff, E. A. M. Seeds
Publikováno v:
Scopus-Elsevier
1 Platelet activating factor (PAF), but not the carrier molecule bovine serum albumin (BSA) induced bronchoconstriction in the anaesthetized rabbit. This bronchoconstriction was not altered by prior treatment with capsaicin. 2 Rabbits demonstrated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fced25b5b8f5a38eb82a629d575373f
http://www.scopus.com/inward/record.url?eid=2-s2.0-0025735399&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0025735399&partnerID=MN8TOARS
