Výsledky vyhledávání - "E. A. Livingstone"

Akademický článek

A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization

Autor: Isaac W. Shaw, Phoebe M. Kirkwood, Diane Rebourcet, Fiona L. Cousins, Rebecca J. Ainslie, Dawn E. W. Livingstone, Lee B. Smith, Philippa T.K. Saunders, Douglas A. Gibson

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Decidualization is the hormone-dependent process of endometrial remodeling that is essential for fertility and reproductive health. It is characterized by dynamic changes in the endometrial stromal compartment including differentiation of fibroblasts

Externí odkaz: https://doaj.org/article/46725ad8d586452ead5a1ec6f1aaf9dc

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High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice

Autor: Hannah M Costello, Georgios Krilis, Celine Grenier, David Severs, Alicja Czopek, Jessica R Ivy, Mark Nixon, Megan C Holmes, Dawn E W Livingstone, Ewout J Hoorn, Neeraj Dhaun, Matthew A Bailey

Publikováno v: Costello, H, Krilis, G, Grenier, C, Severs, D, Czopek, A, Ivy, J R, Nixon, M, Holmes, M C, Livingstone, D E W, Hoorn, E J, Dhaun, N & Bailey, M A 2022, ' High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvac160

Aims High salt intake is common and contributes to poor cardiovascular health. Urinary sodium excretion correlates directly with glucocorticoid excretion in humans and experimental animals. We hypothesized that high salt intake activates the hypothal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96df43a514d5a254e7661b3ca6a200a1
https://pubmed.ncbi.nlm.nih.gov/36368681

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Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation

Autor: Dawn E W Livingstone, John J. Mullins, Kevin Stewart, John Wiseman, James W. Dear, Carmel M. Moran, Bryan R. Conway, Patrick W. F. Hadoke, Laura Denby, Robert I. Menzies, Matthew A. Bailey, Natalie K. Jones, David J. Webb, Alicja Czopek, Adrian Thomson, Carolynn Cairns, Neeraj Dhaun

Publikováno v: Jones, N, Stewart, K, Czopek, A, Menzies, R, Thomson, A W, Moran, C, Cairns, C, Conway, B, Denby, L, Livingstone, D, Wiseman, J, Hadoke, P, Webb, D, Dhaun, N, Dear, J, Mullins, J & Bailey, M 2020, ' Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation ', Hypertension . https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Hypertension (Dallas, Tex. : 1979)

Supplemental Digital Content is available in the text.
GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also expressed in the heart, liver, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db93e9f8bfa30f8527af2997cc8ba983
https://doi.org/10.1161/hypertensionaha.119.14308

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Mechanisms of Salt‐Sensitive Hypertension in a Mouse Model of ACTH‐Dependent Cushing Syndrome

Autor: Céline Grenier, Ailsa F. Ralph, Natalie K. Jones, Neeraj Dhaun, Matthew A. Bailey, Kevin Stewart, Dawn E W Livingstone, Hannah M. Costello

Publikováno v: The FASEB Journal. 33

Salt-sensitive blood pressure (BP) reflects underlying renal and vascular (endothelial) dysfunction. People with abnormal glucocorticoid homeostasis, such as in Cushing syndrome and obesity, are of...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c830cb69c3735aa686e502fda0c0fd1
https://doi.org/10.1096/fasebj.2019.33.1_supplement.569.8

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MON-118 Biochemical and Clinical Correlates of Subcutaneous Adipose mRNA Transcript Levels in Men with T2DM

Autor: Nyo Nyo Tun, Dawn E W Livingstone, Fraser W. Gibb

Publikováno v: Journal of the Endocrine Society

Background: Altered profiles of subcutaneous adipose tissue gene expression have been independently associated with insulin sensitivity. T2DM has been associated with higher levels of adipokines, inflammatory cytokines and lower plasma sex steroid co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0a85d0820aa0b0a124d0f2d3f87e98
https://doi.org/10.1210/js.2019-mon-118

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Role of Hepatic Glucocorticoid Receptor in Metabolism in Models of 5αR1 Deficiency in Male Mice

Autor: Ruth Andrew, Dawn E W Livingstone, Tracy C S Mak, Brian R. Walker, Mark Nixon

Publikováno v: Endocrinology
Mak, T C, Livingstone, D E, Nixon, M, Walker, B R & Andrew, R 2019, ' Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice ', Endocrinology . https://doi.org/10.1210/en.2019-00236

Inhibition of 5α-reductases impairs androgen and glucocorticoid metabolism and induces insulin resistance in humans and rodents. The contribution of hepatic glucocorticoids to these adverse metabolic changes was assessed using a liver-selective gluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17005b6f33ea1931abd1d08d267dbc1f
https://pubmed.ncbi.nlm.nih.gov/31199473

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