Výsledky vyhledávání - "E. A. Lesnik"

Study of exchange of hydrogen for deuterium and tritium in ?-aminoalkylphosphonous acids

Autor: V. V. Shumyantseva, M. Yu. Pokrovskaya, E. A. Lesnik

Publikováno v: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 39:1785-1788

The kinetics of isotope exchange of hydrogen for deuterium in α-aminoalkylphosphonous acids as a function of the pH were investigated by PMR spectroscopy. Tritiumlabeled α-aminoalkylphosphonous acids were obtained as a result of direct hydrogen- tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b34f2ecc4ca2bbd2acb50cfe43c5cfbd
https://doi.org/10.1007/bf00958237

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Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats

Autor: R S, Geary, T A, Watanabe, L, Truong, S, Freier, E A, Lesnik, N B, Sioufi, H, Sasmor, M, Manoharan, A A, Levin

Publikováno v: The Journal of pharmacology and experimental therapeutics. 296(3)

Plasma pharmacokinetics, biodistribution, excretion, and metabolism of four modified 20-mer antisense oligonucleotides targeted to human intercellular adhesion molecule-1 mRNA have been characterized in rats and compared with a first-generation phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6aad7853c4bf95059fa77969d1ce76d0
https://pubmed.ncbi.nlm.nih.gov/11181921

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Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression

Autor: B P, Monia, E A, Lesnik, C, Gonzalez, W F, Lima, D, McGee, C J, Guinosso, A M, Kawasaki, P D, Cook, S M, Freier

Publikováno v: The Journal of biological chemistry. 268(19)

We have used a previously described 17-mer phosphorothioate (Monia, B.P., Johnston, J.F., Ecker, D. J., Zounes, M.A., Lima, W.F., and Freier, S.M. (1992) J. Biol. Chem. 267, 19954-19962) for structure-function analysis of 2'-sugar modifications inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d574443467c36beb313f59db2728b7e3
https://pubmed.ncbi.nlm.nih.gov/8390996

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The inhibition of restriction endonucleases due to Z-DNA in negatively supercoiled plasmid

Autor: Ja.M. Varschavsky, R.N. Maslova, E. A. Lesnik, Zh. A. Beschetnikova

Publikováno v: FEBS letters. 280(1)

Plasmid pGC20 containing the (dGC)??? insert in Sma1 recognition site has been used to study the inhibition of cleavage by different restriction endonucleases due to Z-DNA formation in (dCG)b10 sequence of the negatively supercoiled plasmid. Data obt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44ba0bf0539024ad380ca7dd2643444
https://pubmed.ncbi.nlm.nih.gov/1849100

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[The effect of Z-conformation on enzymatic activity of restriction endonucleases]

Autor: E A, Lesnik, Zh A, Khalimullina

Publikováno v: Molekuliarnaia biologiia. 23(6)

Recombinant plasmid pGC20 containing (GC)9-insert into SmaI site of pUC19 has been used to study the inhibition of cleavage by six restriction endonucleases; KpnI, SacI, EcoRI and also BamHI, XbaI and SalI, due to Z-DNA formation in negatively superc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33985d989c0f3de02b46895132898db6
https://pubmed.ncbi.nlm.nih.gov/2561178

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[Structure of polyriboguanylic acid in solution]

Autor: E A, Lesnik, I M, Kochkina, A S, Tikhonenko, Ia M, Varshavskiĭ

Publikováno v: Molekuliarnaia biologiia. 14(4)

The electron microscopic data and the CD spectra of poly(G) have shown that the transition of a freeze-dried preparation of poly(G) from a "metastable" to a "stable" form is the transition of the four-stranded poly(G) from the globular form to the li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77353772eb831de09a1e1c098c226b68
https://pubmed.ncbi.nlm.nih.gov/7421805

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[Structural characteristics and availability of DNA for solvent molecules in nuclei of Physarum polycephalum]

Autor: I M, Agranovich, I D, Grozdova, L O, Tret'iakov, G N, Lapiashvili, E A, Lesnik

Publikováno v: Molekuliarnaia biologiia. 19(3)

The rate constants of 1H--3H exchange between water and C8H-groups of purinic residues of DNA in solution and in nuclei of synchronous Physarum polycephalum at different phases of the cell cycle were measured. The nuclear membranes and nonhistone pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dcd7812a4386788386eeae6528724190
https://pubmed.ncbi.nlm.nih.gov/4033643

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[Study of conformation characteristics of polydeoxyribonucleotides with non-random base sequence by slow 1H----3H exchange]

Autor: E A, Lesnik, I M, Agranovich, R N, Maslova, Ia M, Varshavskiĭ

Publikováno v: Molekuliarnaia biologiia. 21(2)

The rate constants of 1H----3H exchange between water and C8H-groups of purinic residues of alternating polynucleotides: poly[d(A-T)].poly[d(A-T)] (I), poly[d(G-C)].poly[d(G-C)] (II), poly[d(A-C)].poly[d(G-T)] (III) and homopolynucleotides: poly(dA).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0a85876c41d7aaa2d5b1725a301db94
https://pubmed.ncbi.nlm.nih.gov/3600624

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[Study of conformation characteristics of 'X-form' of alternating polynucleotides by the method of slow 1H----3H transition]

Autor: E A, Lesnik, I M, Agranovich, R N, Maslova, Ia M, Varshavskiĭ

Publikováno v: Molekuliarnaia biologiia. 21(5)

The rate constants of 1H----3H exchange between water and C8H-groups of purine residues of alternating polynucleotides: poly[d(A-C)].poly[d(G-T)] and poly[d(A-T)].poly[d(A-T)], as well as Escherichia coli DNA, dAMP and dGMP, in solutions with high co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55f242805d3de16152611eb8d55227d0
https://pubmed.ncbi.nlm.nih.gov/3683378

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