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Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants

Autor: E A Emini, Anna Karlsson, E. De Clercq, V V Sardana, Jan Balzarini, M J Camarasa

Publikováno v: Scopus-Elsevier

Mutant HIV-1 that expresses a Glu138-->Lys substitution in its RT [(E138K)RT] is resistant to the HIV-1-specific RT inhibitor 2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)pyrimidine (TSAO). However, cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1380f941bb215e67eade8c5863a6fa0e
https://doi.org/10.1073/pnas.91.14.6599

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Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody

Autor: Aby Buchbinder, S. Karwowska, Miroslaw K. Gorny, Susan Zolla-Pazner, A J Conley, E A Emini, S Koenig, Jian-Yin Xu

Publikováno v: Journal of Virology. 66:7538-7542

The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is thought to induce potent neutralizing antibodies which are generally defined as type specific and reactive with individual viral isolates. In contrast, the CD4-binding domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63c35aace1f5839cd18f9b1256c7557
https://doi.org/10.1128/jvi.66.12.7538-7542.1992

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Comparison of pneumococcal conjugate polysaccharide and free polysaccharide vaccines in elderly adults: conjugate vaccine elicits improved antibacterial immune responses and immunological memory

Autor: Andrés, de Roux, B, Schmöle-Thoma, B, Schmöele-Thoma, G R, Siber, J G, Hackell, A, Kuhnke, N, Ahlers, S A, Baker, A, Razmpour, E A, Emini, P D, Fernsten, W C, Gruber, S, Lockhart, O, Burkhardt, T, Welte, H M, Lode

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 46(7)

Background. High functional antibody responses, establishment of immunologic memory, and unambiguous efficacy in infants suggest that an initial dose of conjugated pneumococcal polysaccharide (PnC) vaccine may be of value in a comprehensive adult imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97c8c50b43576e145b1d67cab6507f2
https://pubmed.ncbi.nlm.nih.gov/18444818

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X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform

Autor: Z, Chen, Y, Yan, S, Munshi, Y, Li, J, Zugay-Murphy, B, Xu, M, Witmer, P, Felock, A, Wolfe, V, Sardana, E A, Emini, D, Hazuda, L C, Kuo

Publikováno v: Journal of molecular biology. 296(2)

The crystal structure of simian immunodeficiency virus (SIV) integrase that contains in a single polypeptide the core and the C-terminal deoxyoligonucleotide binding domain has been determined at 3 A resolution with an R-value of 0.203 in the space g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55ef13d3dcadac66186ac33f72d77e8a
https://pubmed.ncbi.nlm.nih.gov/10669606

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In vivo selection of HIV-1 variants with reduced susceptibility to the protease inhibitor L-735,524 and related compounds

Autor: E A, Emini, W A, Schleif, P, Deutsch, J H, Condra

Publikováno v: Advances in experimental medicine and biology. 394

L-735,524 is a potent inhibitor of the HIV-1 protease. In cell culture, the compound interferes with virus replication by causing production of noninfectious immature viral particles containing an unprocessed gag-pol polyprotein. Initial human clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a4a8cd4ecda5b71f034e5b133eae37d
https://pubmed.ncbi.nlm.nih.gov/8815697

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Peptide substrate cleavage specificity of the human cytomegalovirus protease

Autor: V V, Sardana, J A, Wolfgang, C A, Veloski, W J, Long, K, LeGrow, B, Wolanski, E A, Emini, R L, LaFemina

Publikováno v: The Journal of biological chemistry. 269(20)

The human cytomegalovirus UL80 gene encodes an 80-kDa precursor polyprotein whose N-terminal 256-amino acid domain is a protease. This enzyme cleaves a specific peptide bond that results in its own release from the precursor, as well as a peptide bon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed52e4994c2a5a6bebdae91383160dcb
https://pubmed.ncbi.nlm.nih.gov/8182034

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Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase

Autor: D J, Hazuda, A L, Wolfe, J C, Hastings, H L, Robbins, P L, Graham, R L, LaFemina, E A, Emini

Publikováno v: The Journal of biological chemistry. 269(6)

A DNA binding assay was developed for the human immunodeficiency virus type 1 (HIV-1) integrase. The assay was capable of defining discrete complexes between the enzyme and the viral long terminal repeat (LTR) substrate. DNA binding reflected the seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5167974e15e7358498a5dae115a39c7c
https://pubmed.ncbi.nlm.nih.gov/8307956

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The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors

Autor: E A, Emini, V W, Byrnes, J H, Condra, W A, Schleif, V V, Sardana

Publikováno v: Archives of virology. Supplementum. 9

The nonnucleoside reverse transcriptase (RT) inhibitors are structurally diverse compounds that are specific inhibitors of the human immunodeficiency virus type 1 RT enzyme. The compounds are largely functionally identical and bind to a common site i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9fefba561dca10e8c73a221d053f80be
https://pubmed.ncbi.nlm.nih.gov/7518271

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