Zobrazeno 1 - 7
of 7
pro vyhledávání: '"E. A. Bellomo"'
Autor:
E. A. Bellomo, Wolfgang Maret, Kshetrimayum Birla Singh, Christer Hogstrand, Alberto Massarotti
Publikováno v:
Coordination Chemistry Reviews
Bellomo, E, Singh, K B, Massarotti, A, Hogstrand, C & Maret, W 2016, ' The Metal Face of Protein Tyrosine Phosphatase 1B ', COORDINATION CHEMISTRY REVIEWS, vol. 327-328, pp. 70-83 . https://doi.org/10.1016/j.ccr.2016.07.002
Bellomo, E, Singh, K B, Massarotti, A, Hogstrand, C & Maret, W 2016, ' The Metal Face of Protein Tyrosine Phosphatase 1B ', COORDINATION CHEMISTRY REVIEWS, vol. 327-328, pp. 70-83 . https://doi.org/10.1016/j.ccr.2016.07.002
Highlights • Modulation of phosphatase activity by metal cations and metal oxyanions. • Zinc inhibition of protein tyrosine phosphatase 1B. • Structural chemistry of inhibitory metal sites in proteins. • Metal buffering in enzymatic assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954845d98add68fdac4e44b5b00870b2
http://europepmc.org/articles/PMC5115158
http://europepmc.org/articles/PMC5115158
Publikováno v:
Bellomo, E, Abro, A, Hogstrand, C, Maret, W & Domene, C 2018, ' Role of Zinc and Magnesium Ions in the Modulation of Phosphoryl Transfer in Protein Tyrosine Phosphatase 1B ', Journal of the American Chemical Society, vol. 140, no. 12, pp. 4446-4454 . https://doi.org/10.1021/jacs.8b01534
Bellomo, E, Abro, A, Hogstrand, C, Maret, W & Domene, C 2018, ' Role of zinc and magnesium ions in the modulation of phosphoryl transfer in protein tyrosine phosphatase 1B ', Journal of the American Chemical Society, vol. 140, no. 12, pp. 4446-4454 . https://doi.org/10.1021/jacs.8b01534
Bellomo, E, Abro, A, Hogstrand, C, Maret, W & Domene, C 2018, ' Role of zinc and magnesium ions in the modulation of phosphoryl transfer in protein tyrosine phosphatase 1B ', Journal of the American Chemical Society, vol. 140, no. 12, pp. 4446-4454 . https://doi.org/10.1021/jacs.8b01534
While the majority of phosphatases are metalloenzymes, the prevailing model for the reactions catalyzed by protein tyrosine phosphatases does not involve any metal ion, yet both metal cations and oxoanions affect their enzymatic activity. Mg 2+ and Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688f67b9f280f13d80a652eb5cb759b6
https://kclpure.kcl.ac.uk/en/publications/86841244-fcf0-4d5c-990c-9e2a51f056d1
https://kclpure.kcl.ac.uk/en/publications/86841244-fcf0-4d5c-990c-9e2a51f056d1
Publikováno v:
Metallomics. 6:1229-1239
Protein tyrosine phosphatases (PTPs) are key enzymes in cellular regulation. The 107 human PTPs are regulated by redox signalling, phosphorylation, dimerisation, and proteolysis. Recent findings of very strong inhibition of some PTPs by zinc ions at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaccba5a7d469721c7f3c8913a8c362
https://doi.org/10.1039/c4mt00086b
https://doi.org/10.1039/c4mt00086b
Autor:
E. A. Bellomo, Wolfgang Maret, David J. Hodson, Antonia Solomou, Ming Hu, Guy A. Rutter, Ryan K. Mitchell, Pauline Chabosseau
Publikováno v:
The Proceedings of the Nutrition Society. 75(1)
Zinc is an important micronutrient, essential in the diet to avoid a variety of conditions associated with malnutrition such as diarrhoea and alopecia. Lowered circulating levels of zinc are also found in diabetes mellitus, a condition which affects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f794c89dfb959eaedfa782d37f501771
https://pubmed.ncbi.nlm.nih.gov/26365743
https://pubmed.ncbi.nlm.nih.gov/26365743
Autor:
E. A. Bellomo, Malgorzatta Zatyka, Guy A. Rutter, Francesco Michelangeli, Wendy Leadbeater, Dewi Astuti, Gabriela da Silva Xavier, Timothy Barrett, Joel Smith
Wolfram syndrome is an autosomal recessive disorder characterized by neurodegeneration and diabetes mellitus. The gene responsible for the syndrome (WFS1) encodes an endoplasmic reticulum (ER)-resident transmembrane protein that is involved in the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c81becd704888fa3b29b53d330d3fa
http://hdl.handle.net/10044/1/25389
http://hdl.handle.net/10044/1/25389
Publikováno v:
Free Radical Biology and Medicine. 75:S9
Zinc ions, though redox-inert, have either pro-antioxidant or pro-oxidant functions at critical junctures in redox metabolism and redox signalling. They are released from cells and in cells, e.g. from metallothionein, a protein that transduces redox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e8c350487e45b30e3597977a784a04
https://doi.org/10.1016/j.freeradbiomed.2014.10.851
https://doi.org/10.1016/j.freeradbiomed.2014.10.851
Autor:
Tomeo Carmine, CATURANO, UMBERTO
According to the plan we have considered the problem of identifying new indicators, as a challenge not merely theoretical but oriented in progress to an effective implementation and application within the recognized quality protocols. The critical su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::262462a51e109896f7733d8cfbfd90f6
http://hdl.handle.net/11588/691082
http://hdl.handle.net/11588/691082