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Akademický článek

Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Autor: Xi Lu, Naga Prathyusha Maturi, Malin Jarvius, Irem Yildirim, Yonglong Dang, Linxuan Zhao, Yuan Xie, E-Jean Tan, Pengwei Xing, Rolf Larsson, Mårten Fryknäs, Lene Uhrbom, Xingqi Chen

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

The epigenetic regulation of glioblastoma stem cell (GSC) function remains poorly understood. Here, the authors compare the chromatin accessibility landscape of GSC cultures from mice and patients and suggest that the epigenome of GSCs is cell lineag

Externí odkaz: https://doaj.org/article/54f5b29285c34347a7324d03fb75af42

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LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Autor: Naga Prathyusha Maturi, Anders Sundström, Malin Tirfing, Voichita D. Marinescu, Sven Nelander, E-Jean Tan, Lene Uhrbom, Lei Chen, Yiwen Jiang, Fredrik J. Swartling, Magnus Essand, Chuan Jin, Yuan Xie, Malin Jarvius

Publikováno v: The Journal of Pathology. 247:228-240

Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor which lacks efficient treatment and predictive biomarkers. Expression of the epithelial stem cell marker Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::059988ad53af89caadc3719900080488
https://doi.org/10.1002/path.5186

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Conserved cell-lineage controlled epigenetic regulation in human and mouse glioblastoma stem cells determines functionally distinct subgroups

Autor: E-Jean Tan, Xingqi Chen, Yuan Xie, Pengwei Xing, Lene Uhrbom, Xi Lu, Mårten Fryknäs, Malin Jarvius, Naga Prathyusha Maturi, Linxuan Zhao

There is ample support for developmental regulation of glioblastoma stem cells (GSCs). To examine how cell lineage controls GSC function we have performed a cross-species epigenome analysis of mouse and human GSC cultures. We have analyzed and compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82e82d9f2a5f362114013965e8e38db1
https://doi.org/10.1101/2021.02.22.431953

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ECOA-7. Conserved cell-lineage controlled chromatin accessibility in human and mouse glioblastoma stem cells predicts functionally distinct subgroups

Autor: Lene Uhrbom, Pengwei Xing, Mårten Fryknäs, Yuan Xie, Xi Lu, Linxuan Zhao, Xingqi Chen, Malin Jarvius, Naga Prathyusha Maturi, E-Jean Tan

Publikováno v: Neuro-Oncology Advances. 3:ii2-ii2

There is ample support for developmental control of glioblastoma stem cells (GSCs), and a deeper knowledge of their epigenetic regulation could be central to more efficient glioblastoma (GBM) therapies. For this purpose, we analyzed the chromatin-acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15dce0f53ef78b32347c134aa233bcaa
https://doi.org/10.1093/noajnl/vdab070.007

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A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

Autor: Naga Prathyusha Maturi, Yuan Xie, Tobias Bergström, Anders Sundström, Lene Uhrbom, Yiwen Jiang, E-Jean Tan

Publikováno v: GliaREFERENCES. 68(6)

Glioblastoma (GBM) is the most frequent and deadly primary malignant brain tumor. Hallmarks are extensive intra-tumor and inter-tumor heterogeneity and highly invasive growth, which provide great challenges for treatment. Efficient therapy is lacking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0603ef7e4de52dc57b316f4b0937ba00
https://pubmed.ncbi.nlm.nih.gov/31868967

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LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Autor: Yuan, Xie, Anders, Sundström, Naga P, Maturi, E-Jean, Tan, Voichita D, Marinescu, Malin, Jarvius, Malin, Tirfing, Chuan, Jin, Lei, Chen, Magnus, Essand, Fredrik J, Swartling, Sven, Nelander, Yiwen, Jiang, Lene, Uhrbom

Publikováno v: The Journal of pathology. 247(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4dbd805e00ef3e9590f81e523293f6a4
https://pubmed.ncbi.nlm.nih.gov/30357839

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Epithelial–Mesenchymal Transition

Autor: Laia Caja, E-Jean Tan

Epithelial–mesenchymal transition (EMT) is a vital process that takes place during embryogenesis and cancer progression. Epithelial cells shed their adhesive characteristics to acquire mesenchymal properties that allow them to become motile. Tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6c96da42968a6a3363af59a64c25a7f
https://doi.org/10.1016/b978-0-12-801238-3.65024-9

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CBIO-25. HIGH EXPRESSION OF LGR5 MAINTAINS GLIOBLASTOMA STEM CELLS IN A PRONEURAL STATE AND PROMOTES SELF-RENEWAL AND INVASION

Autor: Chuan Jin, Yiwen Jiang, Fredrik J. Swartling, Malin Tirfing, Magnus Essand, Voichita D. Marinescu, Sven Nelander, E-Jean Tan, Andries Blokzijl, Naga Prathyusha Maturi, Yuan Xie, Lene Uhrbom, Lei Chen, Anders Sundström

We have recently identified LGR5 as a marker of an immature, neural stem cell-like cell of origin for glioblastoma (GBM). Here we have further investigated the role of LGR5 in GBM. We have found that in a panel of 61 patient-derived GBM stem cell lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57300eec36e4c3f20084c53901accdfe
https://europepmc.org/articles/PMC5692820/

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Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells

Autor: Laia, Caja, Kalliopi, Tzavlaki, Mahsa S, Dadras, E-Jean, Tan, Gad, Hatem, Naga P, Maturi, Anita, Morén, Lotta, Wik, Yukihide, Watanabe, Katia, Savary, Masood, Kamali-Moghaddan, Lene, Uhrbom, Carl-Henrik, Heldin, Aristidis, Moustakas

Publikováno v: Oncogene

Glioblastoma multiforme is a brain malignancy characterized by high heterogeneity, invasiveness, and resistance to current therapies, attributes related to the occurrence of glioma stem cells (GSCs). Transforming growth factor β (TGFβ) promotes sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c631023c4bce9c7868596c64e665ec0
https://pubmed.ncbi.nlm.nih.gov/29449696

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Reprogramming during epithelial to mesenchymal transition under the control of TGFβ

Autor: E-Jean Tan, Anna-Karin Olsson, Aristidis Moustakas

Publikováno v: Cell Adhesion & Migration. 9:233-246

Epithelial-mesenchymal transition (EMT) refers to plastic changes in epithelial tissue architecture. Breast cancer stromal cells provide secreted molecules, such as transforming growth factor β (TGFβ), that promote EMT on tumor cells to facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08380a5f3e98fb3aec48587921adefd
https://doi.org/10.4161/19336918.2014.983794

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