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Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
Tumor weights were measured upon euthanasia for both the Cal62 DasRes and Parental cell lines treated for 29 days with 1mg/kg QD trametinib. Data as means +/- SEM (n=8; student t-test; ***, P < 0.0005)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164d7e6f76f0ebab1bf5fc376403e940
https://doi.org/10.1158/1535-7163.22508268.v1
https://doi.org/10.1158/1535-7163.22508268.v1
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
A.) Densitometry quantification of ERK 1/2 phosphorylation. Fold changes were calculated based on the control cell lines being normalized to 1. Signals were normalized to α-tubulin. Quantification represents the mean of at least 3 separate experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b021bffbf86e5acae362abb95db5da
https://doi.org/10.1158/1535-7163.22508280
https://doi.org/10.1158/1535-7163.22508280
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
A.) Clonogenic growth was detected by crystal violet staining in the BCPAP and Cal62 cell lines following 6 days of treatment with indicated inhibitors and 6 days of treatment release. B.) Colony area signal intensity was measured using Odyssey CLx i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c80c203daad6a816b467c74a8c10bb
https://doi.org/10.1158/1535-7163.22508262
https://doi.org/10.1158/1535-7163.22508262
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
IC50 values were calculated using the PRISM software and non-variable slope. Fold change relative to control IC50 values are depicted as relative resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402c0be0fc12910b4c2a406569029e7f
https://doi.org/10.1158/1535-7163.22508256
https://doi.org/10.1158/1535-7163.22508256
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
Methods section for supplemental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4562933c09829141f97b4858cb447e8a
https://doi.org/10.1158/1535-7163.22508259
https://doi.org/10.1158/1535-7163.22508259
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
A.) IC50 values were calculated using the PRISM software and non-variable slope analysis. Fold increase in sensitivity was calculated based on changes IC50 values in the DasRes + 2μM dasatinib in relation to the DasRes cell line IC50 values.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35afd363a0c55cba5f2b284f319784e
https://doi.org/10.1158/1535-7163.22508250
https://doi.org/10.1158/1535-7163.22508250
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
A.) Cell lines C643, Cal62, BCPAP, and SW1736, were treated with increasing doses of dasatinib ranging from (0.019 μM to 1.25 μM) for 72 hours, in combination with increasing doses of selumetinib (0.025 μM to 1 μM). Cell growth was measured using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5321f90baddeb9908590e22e216a877f
https://doi.org/10.1158/1535-7163.22508265.v1
https://doi.org/10.1158/1535-7163.22508265.v1
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
The Kegg pathway Melanoma was enriched (p-value: 0.1465), enriched in the DasRes cell lines. Portrayed are the genes in the melanoma pathway. Highlighted in dark grey are genes that are enriched in the dasatinib-resistant cell lines. Genes enriched i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f471203ba6867305c1629c0fe2d9657
https://doi.org/10.1158/1535-7163.22508283.v1
https://doi.org/10.1158/1535-7163.22508283.v1
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
A.) Immunoprecipitation of c-Raf and western blot for B-Raf and c-Raf in whole cell lysates (WCL) following a three hour treatment with 5 μM dasatinib or an equivalent amount of DMSO, in the A375, BCPAP, and Cal62 cell lines. B.) Densitometry quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5365bac6b2a63bce26e43fb2055547ca
https://doi.org/10.1158/1535-7163.22508274.v1
https://doi.org/10.1158/1535-7163.22508274.v1