Zobrazeno 1 - 10
of 49
pro vyhledávání: '"E Wolfgang Kuehn"'
Autor:
Christopher Boehlke, Heike Janusch, Christoph Hamann, Christian Powelske, Miriam Mergen, Henriette Herbst, Fruzsina Kotsis, Roland Nitschke, E Wolfgang Kuehn
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140378 (2015)
Ift88 is a central component of the intraflagellar transport (Ift) complex B, essential for the building of cilia and flagella from single cell organisms to mammals. Loss of Ift88 results in the absence of cilia and causes left-right asymmetry defect
Externí odkaz:
https://doaj.org/article/c6d3079627674cc39cb41c78cc4c1f4c
Autor:
Christopher Boehlke, Fruzsina Kotsis, Bjoern Buchholz, Christian Powelske, Kai-Uwe Eckardt, Gerd Walz, Roland Nitschke, E Wolfgang Kuehn
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62165 (2013)
The microtubular motor Kinesin-2 and its subunit Kif3a are essential for the formation of primary cilia, an organelle implicated in a wide spectrum of developmental abnormalities. Outside cilia, Kinesin-2 mediated transport has been implicated in ves
Externí odkaz:
https://doaj.org/article/be23e26d5b8242f68b1091e6e9e87315
Autor:
Roland Thuenauer, Katja Kühn, Yubing Guo, Fruzsina Kotsis, Maokai Xu, Anne Trefzer, Silke Altmann, Sarah Wehrum, Najmeh Heshmatpour, Brian Faust, Alessia Landi, Britta Diedrich, Jörn Dengjel, E. Wolfgang Kuehn, Anne Imberty, Winfried Römer
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT The opportunistic bacterium Pseudomonas aeruginosa can infect mucosal tissues of the human body. To persist at the mucosal barrier, this highly adaptable pathogen has evolved many strategies, including invasion of host cells. Here, we show t
Externí odkaz:
https://doaj.org/article/e135b4483a924f88ab0c8b3fcb3a5553
Autor:
Amandine Viau, Gerd Walz, Esben Lorentzen, Heike Janusch, Athina Ganner, Fruzsina Kotsis, Albrecht Kramer-Zucker, Christopher Boehlke, Roland Nitschke, Daniel Epting, Yujie Li, Elke Neumann-Haefelin, E. Wolfgang Kuehn
Publikováno v:
Kotsis, F, Janusch, H, Li, Y, Viau, A, Epting, D, Kramer-Zucker, A, Walz, G, Nitschke, R, Lorentzen, E, Ganner, A, Neumann-Haefelin, E, Kuehn, E W & Boehlke, C 2021, ' Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment ', Biochemical and Biophysical Research Communications, vol. 584, pp. 19-25 . https://doi.org/10.1016/j.bbrc.2021.10.075
The primary cilium is a sensory organelle at the cell surface with integral functions in cell signaling. It contains a microtubular axoneme that is rooted in the basal body (BB) and serves as a scaffold for the movement of intraflagellar transport (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bd892c18036ca5cadf7a4f5379a30b
https://doi.org/10.1016/j.bbrc.2021.10.075
https://doi.org/10.1016/j.bbrc.2021.10.075
Autor:
Roman Pichler, Ludovica Rizzo, Kevin Tröndle, Michaela Bühler, Hanna Brucker, Anna-Lena Müller, Kelli Grand, Silvia Farè, Amandine Viau, Michael M. Kaminski, E. Wolfgang Kuehn, Fritz Koch, Stefan Zimmermann, Peter Koltay, Soeren S. Lienkamp
Publikováno v:
Biomaterials. 291
Renal tubular cells frequently lose differentiation markers and physiological properties when propagated in conventional cell culture conditions. Embedding cells in 3D microenvironments or controlling their 3D assembly by bioprinting can enhance thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87e067270303ffef91c830f350a5f4b
https://pubmed.ncbi.nlm.nih.gov/36403325
https://pubmed.ncbi.nlm.nih.gov/36403325
Autor:
E. Wolfgang Kuehn, Amandine Viau, Alexis Hofherr, Tilman Busch, Anusha Venkatraman, Lukas Peintner, Christoph Borner, Alexander Voronov, Astrid Waeldin, Michael Köttgen
Publikováno v:
Autophagy
Mutations in the PKD1 gene result in autosomal dominant polycystic kidney disease (ADPKD), the most common monogenetic cause of end-stage renal disease (ESRD) in humans. Previous reports suggested that PKD1, together with PKD2/polycystin-2, may funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626f5ff9016a8cc0240a772865e9bf1b
https://doi.org/10.1080/15548627.2020.1826716
https://doi.org/10.1080/15548627.2020.1826716
Autor:
Simone Braeg, Amandine Viau, Gerd Walz, Roland Nitschke, Marinella Klein, Fruzsina Kotsis, E. Wolfgang Kuehn, Christopher Boehlke
Publikováno v:
Biochemical and Biophysical Research Communications. 521:290-295
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2, the genes encoding polycystin 1 (PC1) and polycystin 2 (PC2), respectively. PC1 and PC2 localize to the primary cilium and form a protein complex, which is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c23c15c904e7f5b2e259db47d898a5
https://doi.org/10.1016/j.bbrc.2019.10.074
https://doi.org/10.1016/j.bbrc.2019.10.074
Autor:
Giulia Ferri, Valentine Goffette, Esther Porée, Simone Braeg, Shana Carvalho, Marceau Quatredeniers, E. Wolfgang Kuehn, Sophie Saunier, Amandine Viau
Nephronophthisis (NPH) is an orphan recessive kidney disease mostly caused by mutations in NPHP1 and 20 other genes encoding proteins that localize to primary cilia. To date the pathways linking altered primary cilia function to progressive kidney sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e42af3d3e28493abe64aad2fa52dfdc
https://doi.org/10.1101/2022.01.17.475784
https://doi.org/10.1101/2022.01.17.475784
Autor:
Marceau Quatredeniers, Frank Bienaimé, Giulia Ferri, Pierre Isnard, Esther Porée, Katy Billot, Eléonore Birgy, Manal Mazloum, Salomé Ceccarelli, Flora Silbermann, Simone Braeg, Thao Nguyen-Khoa, Rémi Salomon, Marie-Claire Gubler, E Wolfgang Kuehn, Sophie Saunier, Amandine Viau
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, 2022, 31 (13), pp.2121-2136. ⟨10.1093/hmg/ddac014⟩
Human Molecular Genetics, 2022, 31 (13), pp.2121-2136. ⟨10.1093/hmg/ddac014⟩
Renal ciliopathies are the leading cause of inherited kidney failure. In autosomal dominant polycystic kidney disease (ADPKD), mutations in the ciliary gene PKD1 lead to the induction of CCL2, which promotes macrophage infiltration in the kidney. Whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef07f0e3c61895c5e9b025a9333d6f87
https://pubmed.ncbi.nlm.nih.gov/35043953
https://pubmed.ncbi.nlm.nih.gov/35043953
Autor:
Christopher Boehlke, Fruzsina Kotsis, Bjoern Buchholz, Christian Powelske, Kai-Uwe Eckardt, Gerd Walz, Roland Nitschke, E. Wolfgang Kuehn
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
Externí odkaz:
https://doaj.org/article/655ffe742afe43e48c9be7155a2fe0e8