Zobrazeno 1 - 10
of 240
pro vyhledávání: '"E Wicks"'
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionNontraumatic subarachnoid hemorrhage (ntSAH) often results from a ruptured aneurysm and correlates with significant morbidity and mortality, particularly among the older population. Despite its impact, limited comprehensive studies evalua
Externí odkaz:
https://doaj.org/article/bbe891ee8f28463f9d7ba96d7f8f78a6
Autor:
Yajing Lyu, Yongkang Yang, Varen Talwar, Haiquan Lu, Chelsey Chen, Shaima Salman, Elizabeth E. Wicks, Tina Yi-Ting Huang, Daiana Drehmer, Yufeng Wang, Qiaozhu Zuo, Emmanuel Datan, Walter Jackson, III, Dominic Dordai, Ru Wang, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113972- (2024)
Summary: Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates cellular adaptation to decreased oxygen availability. HIF-1 recruits chromatin-modifying enzymes leading to changes in histone acetylation, citrullination, and m
Externí odkaz:
https://doaj.org/article/81c1beb3ca954c18aaff5e6ff94c9e4a
Autor:
Qiaozhu Zuo, Yongkang Yang, Yajing Lyu, Chen Yang, Chelsey Chen, Shaima Salman, Tina Yi-Ting Huang, Elizabeth E. Wicks, Walter Jackson, III, Emmanuel Datan, Wenxin Qin, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112164- (2023)
Summary: Intratumoral hypoxia is a microenvironmental feature that promotes breast cancer progression and is associated with cancer mortality. Plexin B3 (PLXNB3) is highly expressed in estrogen receptor-negative breast cancer, but the underlying mech
Externí odkaz:
https://doaj.org/article/33aaf8ed82ef405fa617b1722f2239c3
Autor:
Elizabeth E. Wicks, Gregg L. Semenza
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2 supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co-opt this homeostatic system to drive cancer progression. HIFs acti
Externí odkaz:
https://doaj.org/article/ea9b829e75b64d9098094fb70f374180
Autor:
Elizabeth E. Wicks, Kathleen R. Ran, Jennifer E. Kim, Risheng Xu, Ryan P. Lee, Christopher M. Jackson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The immune response to ischemic stroke is an area of study that is at the forefront of stroke research and presents promising new avenues for treatment development. Upon cerebral vessel occlusion, the innate immune system is activated by danger-assoc
Externí odkaz:
https://doaj.org/article/d42e1905171f478e92e3bb0d449beb2c
Autor:
Shaima Salman, David J. Meyers, Elizabeth E. Wicks, Sophia N. Lee, Emmanuel Datan, Aline M. Thomas, Nicole M. Anders, Yousang Hwang, Yajing Lyu, Yongkang Yang, Walter Jackson III, Dominic Dordai, Michelle A. Rudek, Gregg L. Semenza
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and available therapies, including immunotherapies, are ineffective for many patients. HCC is characterized by intratumoral hypoxia, and increased expression of hypoxia-ind
Externí odkaz:
https://doaj.org/article/93de6172546f4b1dba403323cea12053
Autor:
Goodwell Nzou, R. T. Wicks, E. E. Wicks, S. A. Seale, C. H. Sane, A. Chen, S. V. Murphy, J. D. Jackson, A. J. Atala
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The integral selectivity characteristic of the blood brain barrier (BBB) limits therapeutic options for many neurologic diseases and disorders. Currently, very little is known about the mechanisms that govern the dynamic nature of the BBB. R
Externí odkaz:
https://doaj.org/article/d0f27afeb18f49458be4b285d482ac08
Autor:
Z Ashkir, S Johnson, A J Lewandowski, A Hess, E Wicks, M Mahmod, S Myerson, T Ebbers, H Watkins, S Neubauer, C J Carlhäll, B Raman
Publikováno v:
European Heart Journal - Cardiovascular Imaging.
Aims Hypertrophic cardiomyopathy (HCM) is characterized by hypercontractility and diastolic dysfunction, which alter blood flow haemodynamics and are linked with increased risk of adverse clinical events. Four-dimensional flow cardiac magnetic resona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81fe422dbd601a8d954bbe51d9dfe306
https://doi.org/10.1093/ehjci/jead074
https://doi.org/10.1093/ehjci/jead074
Autor:
Bolormaa Vandanmagsar, Jaycob D. Warfel, Shawna E. Wicks, Sujoy Ghosh, J. Michael Salbaum, David Burk, Olga S. Dubuisson, Tamra M. Mendoza, Jingying Zhang, Robert C. Noland, Randall L. Mynatt
Publikováno v:
Cell Reports, Vol 15, Iss 8, Pp 1686-1699 (2016)
Fatty acids are the primary fuel source for skeletal muscle during most of our daily activities, and impaired fatty acid oxidation (FAO) is associated with insulin resistance. We have developed a mouse model of impaired FAO by deleting carnitine palm
Externí odkaz:
https://doaj.org/article/b3b97042ce4a4ec0af7b68f7d9d0633f
Autor:
James Feghali, Shahab Aldin Sattari, Elizabeth E. Wicks, Abhishek Gami, Sarah Rapaport, Tej D. Azad, Wuyang Yang, Risheng Xu, Rafael J. Tamargo, Judy Huang
Publikováno v:
Neurosurgery. 90:552-561
Interest in machine learning (ML)-based predictive modeling has led to the development of models predicting outcomes after aneurysmal subarachnoid hemorrhage (aSAH), including the Nijmegen acute subarachnoid hemorrhage calculator (Nutshell). Generali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a3416de6b60c02347347e490319d80
https://doi.org/10.1227/neu.0000000000001857
https://doi.org/10.1227/neu.0000000000001857