Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers.

Autor: Michael Francis, Kenneth E Westerman, Alisa K Manning, Kaixiong Ye

Publikováno v: PLoS Genetics, Vol 20, Iss 7, p e1011288 (2024)

We examined the associations of vegetarianism with metabolic biomarkers using traditional and genetic epidemiology. First, we addressed inconsistencies in self-reported vegetarianism among UK Biobank participants by utilizing data from two dietary su

Externí odkaz: https://doaj.org/article/d9399f1fdfca40e5bb9f1b6d13f6ad81

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program

Autor: Daniel DiCorpo, Sheila M. Gaynor, Emily M. Russell, Kenneth E. Westerman, Laura M. Raffield, Timothy D. Majarian, Peitao Wu, Chloé Sarnowski, Heather M. Highland, Anne Jackson, Natalie R. Hasbani, Paul S. de Vries, Jennifer A. Brody, Bertha Hidalgo, Xiuqing Guo, James A. Perry, Jeffrey R. O’Connell, Samantha Lent, May E. Montasser, Brian E. Cade, Deepti Jain, Heming Wang, Ricardo D’Oliveira Albanus, Arushi Varshney, Lisa R. Yanek, Leslie Lange, Nicholette D. Palmer, Marcio Almeida, Juan M. Peralta, Stella Aslibekyan, Abigail S. Baldridge, Alain G. Bertoni, Lawrence F. Bielak, Chung-Shiuan Chen, Yii-Der Ida Chen, Won Jung Choi, Mark O. Goodarzi, James S. Floyd, Marguerite R. Irvin, Rita R. Kalyani, Tanika N. Kelly, Seonwook Lee, Ching-Ti Liu, Douglas Loesch, JoAnn E. Manson, Ryan L. Minster, Take Naseri, James S. Pankow, Laura J. Rasmussen-Torvik, Alexander P. Reiner, Muagututi’a Sefuiva Reupena, Elizabeth Selvin, Jennifer A. Smith, Daniel E. Weeks, Huichun Xu, Jie Yao, Wei Zhao, Stephen Parker, Alvaro Alonso, Donna K. Arnett, John Blangero, Eric Boerwinkle, Adolfo Correa, L. Adrienne Cupples, Joanne E. Curran, Ravindranath Duggirala, Jiang He, Susan R. Heckbert, Sharon L. R. Kardia, Ryan W. Kim, Charles Kooperberg, Simin Liu, Rasika A. Mathias, Stephen T. McGarvey, Braxton D. Mitchell, Alanna C. Morrison, Patricia A. Peyser, Bruce M. Psaty, Susan Redline, Alan R. Shuldiner, Kent D. Taylor, Ramachandran S. Vasan, Karine A. Viaud-Martinez, Jose C. Florez, James G. Wilson, Robert Sladek, Stephen S. Rich, Jerome I. Rotter, Xihong Lin, Josée Dupuis, James B. Meigs, Jennifer Wessel, Alisa K. Manning

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)

This study of 23,000 non-diabetic individuals highlights loci associated with fasting glucose and fasting insulin in diverse cohorts with whole genome sequence data.

Externí odkaz: https://doaj.org/article/51bbec2d075c4bcf954b08126e8e0bab

Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy

Autor: Daniel D. Shapiro, Niki Millward Zacharias, Durga N. Tripathi, Menuka Karki, Jean‐Philippe Bertocchio, Melinda Soeung, Rong He, Mary E. Westerman, Jianjun Gao, Priya Rao, Truong N. A. Lam, Eric Jonasch, Luigi Perelli, Emily H. Cheng, Alessandro Carugo, Timothy P. Heffernan, Cheryl L. Walker, Giannicola Genovese, Nizar M. Tannir, Jose A. Karam, Pavlos Msaouel

Publikováno v: Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)

Abstract Background Renal medullary carcinoma (RMC) is a highly aggressive cancer in need of new therapeutic strategies. The neddylation pathway can protect cells from DNA damage induced by the platinum‐based chemotherapy used in RMC. We investigat

Externí odkaz: https://doaj.org/article/fca066ea851948459db5570b929f6a14

Genetic heritability as a tool to evaluate the precision of 24-hour recall dietary questionnaire variables in UK Biobank

Autor: Joanne B. Cole, Kenneth E. Westerman, Alisa K. Manning, Jose C. Florez, Joel N. Hirschhorn

Publikováno v: Frontiers in Genetics, Vol 13 (2023)

A variety of statistical approaches in nutritional epidemiology have been developed to enhance the precision of dietary variables derived from longitudinal questionnaires. Correlation with biomarkers is often used to assess the relative validity of t

Externí odkaz: https://doaj.org/article/34a38b96c8534006aacafcb820a5aebc

PhyteByte: identification of foods containing compounds with specific pharmacological properties

Autor: Kenneth E. Westerman, Sean Harrington, Jose M. Ordovas, Laurence D. Parnell

Publikováno v: BMC Bioinformatics, Vol 21, Iss 1, Pp 1-8 (2020)

Abstract Background Phytochemicals and other molecules in foods elicit positive health benefits, often by poorly established or unknown mechanisms. While there is a wealth of data on the biological and biophysical properties of drugs and therapeutic

Externí odkaz: https://doaj.org/article/462b5f5b122f4ba99c75d48f3949b22a