Zobrazeno 1 - 10
of 961
pro vyhledávání: '"E W, Hancock"'
Autor:
David Martino, Nina Kresoje, Nelly Amenyogbe, Rym Ben-Othman, Bing Cai, Mandy Lo, Olubukola Idoko, Oludare A. Odumade, Reza Falsafi, Travis M. Blimkie, Andy An, Casey P. Shannon, Sebastiano Montante, Bhavjinder K. Dhillon, Joann Diray-Arce, Al Ozonoff, Kinga K. Smolen, Ryan R. Brinkman, Kerry McEnaney, Asimenia Angelidou, Peter Richmond, Scott J. Tebbutt, the EPIC-HIPC consortium, Beate Kampmann, Ofer Levy, Robert E. W. Hancock, Amy H. Y. Lee, Tobias R. Kollmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Understanding of newborn immune ontogeny in the first week of life will enable age-appropriate strategies for safeguarding vulnerable newborns against infectious diseases. Here we conducted an observational study exploring the immunological
Externí odkaz:
https://doaj.org/article/f8167ccffdeb4b0d9144c24cdeaf6fcb
Autor:
Mario Fidanza, Julie Hibbert, Erica Acton, Danny Harbeson, Elizna Schoeman, Patrycja Skut, Tabitha Woodman, Adrien Eynaud, Lucy Hartnell, Byron Brook, Bing Cai, Mandy Lo, Reza Falsafi, Robert E. W. Hancock, Msandeni Chiume-Kayuni, Norman Lufesi, Constantin R. Popescu, Pascal M. Lavoie, Tobias Strunk, Andrew J. Currie, Tobias R. Kollmann, Nelly Amenyogbe, Amy H. Lee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repeat
Externí odkaz:
https://doaj.org/article/b54f31f4736543a6a2fa9c599d17c04a
Autor:
Dan Wang, Yingying Yue, He Liu, Tian Zhang, Evan F. Haney, Robert E. W. Hancock, Jian Yu, Ya Shen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Titanium alloys have gained popularity in implant dentistry for the restoration of missing teeth and related hard tissues because of their biocompatibility and enhanced strength. However, titanium corrosion and infection caused by microbial biofilms
Externí odkaz:
https://doaj.org/article/d225993767144d9781d0b56f2e2f8b4e
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
In 2007, the University of British Columbia (UBC) was the first university in Canada to establish and adopt global access (GA) principles. Toward implementing these principles, UBC then identified a set of strategies for providing affordable access t
Externí odkaz:
https://doaj.org/article/76cda94a968348619acf61fc8adfab36
Autor:
Shahid Chaudhary, Zahir Ali, Muhammad Tehseen, Evan F. Haney, Aarón Pantoja-Angles, Salwa Alshehri, Tiannyu Wang, Gerard J. Clancy, Maya Ayach, Charlotte Hauser, Pei-Ying Hong, Samir M. Hamdan, Robert E. W. Hancock, Magdy Mahfouz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Antimicrobial peptides (AMPs) are next-generation antibiotics that can be used to combat drugresistant pathogens. Here, the authors report efficient production of bioactive amidated AMPs by transient expression in Nicotiana benthamiana line expressin
Externí odkaz:
https://doaj.org/article/5c9c30ac73914dbc82b0c57fe0c7631f
Persistence is key: unresolved immune dysfunction is lethal in both COVID-19 and non-COVID-19 sepsis
Autor:
Andy Y. An, Arjun Baghela, Peter Zhang, Reza Falsafi, Amy H. Lee, Uriel Trahtemberg, Andrew J. Baker, Claudia C. dos Santos, Robert E. W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 and non-COVID-19 pulmonary sepsis share pathophysiological, immunological, and clinical features, suggesting that severe COVID-19 is a form of viral sepsis. Our objective was to identify shared gene expression trajectories
Externí odkaz:
https://doaj.org/article/72fa51db86cf4ba7bc093529d5e48e74
Autor:
Arjun Baghela, Andy An, Peter Zhang, Erica Acton, Jeff Gauthier, Elsa Brunet-Ratnasingham, Travis Blimkie, Gabriela Cohen Freue, Daniel Kaufmann, Amy H. Y. Lee, Roger C. Levesque, Robert E. W. Hancock
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Severely-afflicted COVID-19 patients can exhibit disease manifestations representative of sepsis, including acute respiratory distress syndrome and multiple organ failure. We hypothesized that diagnostic tools used in managing all-cause seps
Externí odkaz:
https://doaj.org/article/4a81a36a072744c09fdb25d7139cf960
Autor:
Kenneth C. Smith, Daniel G. Chawla, Bhavjinder K. Dhillon, Zhou Ji, Randi Vita, Eva C. van der Leest, Jing Yi Jessica Weng, Ernest Tang, Amani Abid, The Human Immunology Project Consortium (HIPC), Bjoern Peters, Robert E. W. Hancock, Aris Floratos, Steven H. Kleinstein
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-11 (2022)
Abstract Recent advances in high-throughput experiments and systems biology approaches have resulted in hundreds of publications identifying “immune signatures”. Unfortunately, these are often described within text, figures, or tables in a format
Externí odkaz:
https://doaj.org/article/738fd9d686bc4fa9ae908d01ea059eb9
Autor:
Andy Yi An, Arjun Baghela, Peter G. Y. Zhang, Travis M. Blimkie, Jeff Gauthier, Daniel Elias Kaufmann, Erica Acton, Amy H. Y. Lee, Roger C. Levesque, Robert E. W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPersistent symptoms after COVID-19 infection (“long COVID”) negatively affects almost half of COVID-19 survivors. Despite its prevalence, its pathophysiology is poorly understood, with multiple host systems likely affected. Here, we f
Externí odkaz:
https://doaj.org/article/847c7a1bfa6448129c35b711a7569eb0
Autor:
Andy Y. An, Arjun Baghela, Peter Zhang, Reza Falsafi, Amy H. Lee, Uriel Trahtemberg, Andrew J. Baker, Claudia C. dos Santos, Robert E. W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 and non-COVID-19 pulmonary sepsis share pathophysiological, immunological, and clinical features. To what extent they share mechanistically-based gene expression trajectories throughout hospitalization was unknown. Our obj
Externí odkaz:
https://doaj.org/article/7240eb0474994e7cbedec8b7e33d80b4