Zobrazeno 1 - 10 of 16 pro vyhledávání: '"E W, Alton"'
1
Protocols for in vivo measurement of the ion transport defects in cystic fibrosis nasal epithelium
Autor: P G, Middleton, D M, Geddes, E W, Alton
Publikováno v: European Respiratory Journal. 7:2050-2056
New treatments for cystic fibrosis (CF), including gene therapy, are currently being assessed. These aim to correct the basic defects of increased sodium absorption and decreased chloride secretion in airway epithelia. Assessment of these bioelectric
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542c29a2e20dd6a936d29add9e9ff86b
https://doi.org/10.1183/09031936.94.07112050
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2
Recent progress in gene therapy for cystic fibrosis
Autor: U, Griesenbach, E W, Alton
Publikováno v: Current opinion in molecular therapeutics. 3(4)
Cystic fibrosis (CF) is a monogenic disorder and is therefore a good candidate for gene therapy. Initial clinical trials provided proof-of-principle for gene transfer to the airways, but efficiency was low and likely to be insufficient for clinical b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4691c17ee0463ec88802c14523db8797
https://pubmed.ncbi.nlm.nih.gov/11525562
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4
Prospects for respiratory gene therapy
Autor: E W, Alton, D M, Geddes
Publikováno v: British journal of hospital medicine. 58(1)
Over the last 5 years a number of articles have been published on gene therapy for a range of diseases. The initial tone of a number of these articles evoked high expectations, particularly from the public. Over the last 2-3 years data from these stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::411f7831333e326a44d3edd6b0e3b180
https://pubmed.ncbi.nlm.nih.gov/9337921
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5
Localization and up-regulation of mucin (MUC2) gene expression in human nasal biopsies of patients with cystic fibrosis
Autor: D, Li, D, Wang, S, Majumdar, B, Jany, S R, Durham, J, Cottrell, N, Caplen, D M, Geddes, E W, Alton, P K, Jeffery
Publikováno v: The Journal of pathology. 181(3)
Using digoxigenin-UTP-labelled human HAM-1 (92 bp) or SMUC41 (850 bp) cRNA probes, the expression and localization of MUC2 gene transcripts were determined by in situ hybridization in human nasal tissues obtained as biopsies from 12 patients with cys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4dc51f0f87506719d967f3734e7be45
https://pubmed.ncbi.nlm.nih.gov/9155717
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6
Laboratory and clinical studies in support of cystic fibrosis gene therapy using pCMV-CFTR-DOTAP
Autor: G, McLachlan, L P, Ho, H, Davidson-Smith, J, Samways, H, Davidson, B J, Stevenson, A D, Carothers, E W, Alton, P G, Middleton, S N, Smith, G, Kallmeyer, U, Michaelis, S, Seeber, K, Naujoks, A P, Greening, J A, Innes, J R, Dorin, D J, Porteous
Publikováno v: Gene therapy. 3(12)
The first phase I study of cystic fibrosis gene therapy using cationic liposomes to deliver the cystic fibrosis conductance regulator gene to the nose reported partial and transient correction of the nasal transepithelial ion transport defect, While
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc0c00308a5882775271389e17e8b4e0
https://pubmed.ncbi.nlm.nih.gov/8986438
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7
Chloride transport and the actions of nedocromil sodium and cromolyn sodium in asthma
Autor: E W, Alton, A A, Norris
Publikováno v: The Journal of allergy and clinical immunology. 98(5 Pt 2)
Nedocromil sodium has been shown to be capable of inhibiting chloride ion flux in mast cells, epithelial cells, and neurons. This feature may explain how it can prevent responses such as mast-cell degranulation, the effects of osmolarity changes in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9913e2f586551ad4e6ff3c40d260586
https://pubmed.ncbi.nlm.nih.gov/8939184
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8
A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction
Autor: J R, Dorin, R, Farley, S, Webb, S N, Smith, E, Farini, S J, Delaney, B J, Wainwright, E W, Alton, D J, Porteous
Publikováno v: Gene therapy. 3(9)
Quantifying the level of transgene expression necessary for phenotypic effect is an important consideration in designing somatic gene therapy protocols. A nonlinear relationship between phenotype and gene activity is predicted by control analysis for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6c2dc7de13af9ac02bca7b3176674c3
https://pubmed.ncbi.nlm.nih.gov/8875228
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10
Quantitative fluorescence measurements of chloride secretion in native airway epithelium from CF and non-CF subjects
Autor: M, Stern, F M, Munkonge, N J, Caplen, F, Sorgi, L, Huang, D M, Geddes, E W, Alton
Publikováno v: Gene therapy. 2(10)
Functional assessment of the efficacy of CFTR gene transfer protocols in humans has previously involved measurement of in vivo potential difference. We have studied whether freshly obtained airway epithelial cells may provide suitable tissue for stud
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee8e8c12d34a44a9263017d5e36d19da
https://pubmed.ncbi.nlm.nih.gov/8750017
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