Zobrazeno 1 - 10
of 165
pro vyhledávání: '"E W, Alton"'
Publikováno v:
European Respiratory Journal. 7:2050-2056
New treatments for cystic fibrosis (CF), including gene therapy, are currently being assessed. These aim to correct the basic defects of increased sodium absorption and decreased chloride secretion in airway epithelia. Assessment of these bioelectric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542c29a2e20dd6a936d29add9e9ff86b
https://doi.org/10.1183/09031936.94.07112050
https://doi.org/10.1183/09031936.94.07112050
Autor:
U, Griesenbach, E W, Alton
Publikováno v:
Current opinion in molecular therapeutics. 3(4)
Cystic fibrosis (CF) is a monogenic disorder and is therefore a good candidate for gene therapy. Initial clinical trials provided proof-of-principle for gene transfer to the airways, but efficiency was low and likely to be insufficient for clinical b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4691c17ee0463ec88802c14523db8797
https://pubmed.ncbi.nlm.nih.gov/11525562
https://pubmed.ncbi.nlm.nih.gov/11525562
Publikováno v:
Advances in experimental medicine and biology. 465
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ee57b088bb796f4308892226da7f0b9
https://pubmed.ncbi.nlm.nih.gov/10810640
https://pubmed.ncbi.nlm.nih.gov/10810640
Autor:
E W, Alton, D M, Geddes
Publikováno v:
British journal of hospital medicine. 58(1)
Over the last 5 years a number of articles have been published on gene therapy for a range of diseases. The initial tone of a number of these articles evoked high expectations, particularly from the public. Over the last 2-3 years data from these stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::411f7831333e326a44d3edd6b0e3b180
https://pubmed.ncbi.nlm.nih.gov/9337921
https://pubmed.ncbi.nlm.nih.gov/9337921
Autor:
D, Li, D, Wang, S, Majumdar, B, Jany, S R, Durham, J, Cottrell, N, Caplen, D M, Geddes, E W, Alton, P K, Jeffery
Publikováno v:
The Journal of pathology. 181(3)
Using digoxigenin-UTP-labelled human HAM-1 (92 bp) or SMUC41 (850 bp) cRNA probes, the expression and localization of MUC2 gene transcripts were determined by in situ hybridization in human nasal tissues obtained as biopsies from 12 patients with cys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4dc51f0f87506719d967f3734e7be45
https://pubmed.ncbi.nlm.nih.gov/9155717
https://pubmed.ncbi.nlm.nih.gov/9155717
Autor:
G, McLachlan, L P, Ho, H, Davidson-Smith, J, Samways, H, Davidson, B J, Stevenson, A D, Carothers, E W, Alton, P G, Middleton, S N, Smith, G, Kallmeyer, U, Michaelis, S, Seeber, K, Naujoks, A P, Greening, J A, Innes, J R, Dorin, D J, Porteous
Publikováno v:
Gene therapy. 3(12)
The first phase I study of cystic fibrosis gene therapy using cationic liposomes to deliver the cystic fibrosis conductance regulator gene to the nose reported partial and transient correction of the nasal transepithelial ion transport defect, While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc0c00308a5882775271389e17e8b4e0
https://pubmed.ncbi.nlm.nih.gov/8986438
https://pubmed.ncbi.nlm.nih.gov/8986438
Autor:
E W, Alton, A A, Norris
Publikováno v:
The Journal of allergy and clinical immunology. 98(5 Pt 2)
Nedocromil sodium has been shown to be capable of inhibiting chloride ion flux in mast cells, epithelial cells, and neurons. This feature may explain how it can prevent responses such as mast-cell degranulation, the effects of osmolarity changes in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9913e2f586551ad4e6ff3c40d260586
https://pubmed.ncbi.nlm.nih.gov/8939184
https://pubmed.ncbi.nlm.nih.gov/8939184
Autor:
J R, Dorin, R, Farley, S, Webb, S N, Smith, E, Farini, S J, Delaney, B J, Wainwright, E W, Alton, D J, Porteous
Publikováno v:
Gene therapy. 3(9)
Quantifying the level of transgene expression necessary for phenotypic effect is an important consideration in designing somatic gene therapy protocols. A nonlinear relationship between phenotype and gene activity is predicted by control analysis for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6c2dc7de13af9ac02bca7b3176674c3
https://pubmed.ncbi.nlm.nih.gov/8875228
https://pubmed.ncbi.nlm.nih.gov/8875228
Autor:
A A, Norris, E W, Alton
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 26(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::622c15db8a0ee3084005fc3e00280fee
https://pubmed.ncbi.nlm.nih.gov/8729660
https://pubmed.ncbi.nlm.nih.gov/8729660
Publikováno v:
Gene therapy. 2(10)
Functional assessment of the efficacy of CFTR gene transfer protocols in humans has previously involved measurement of in vivo potential difference. We have studied whether freshly obtained airway epithelial cells may provide suitable tissue for stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee8e8c12d34a44a9263017d5e36d19da
https://pubmed.ncbi.nlm.nih.gov/8750017
https://pubmed.ncbi.nlm.nih.gov/8750017