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Are antibodies to fine specificities of citrullinated peptides/proteins useful for stratification of rheumatoid arthritis patients?

Autor: Emilie Parra, Leonor Nogueira, E Verrouil, Margaux Larrieu, Martin Cornillet

Publikováno v: Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)

Background In rheumatoid arthritis (RA), antibodies to citrullinated protein (ACPA) are believed to be heterogeneous and patient stratification by antibody profiling raised clinical interest for patient management. However, heterogeneity might be par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865f13c49ba7f8c8a6d586c30f259f54
http://europepmc.org/articles/PMC8256671

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Seropositivity and Antibody Profiling of Patients Are Dramatically Impacted by the Features of Peptides Used as Immunosorbents: A Lesson from Anti–Citrullinated Protein/Peptide Antibody

Autor: Guy Serre, Anna Magyar, Ferenc Hudecz, Fruzsina Babos, Martin Cornillet, E Verrouil, Leonor Nogueira, Mireille Sebbag

Publikováno v: The Journal of Immunology. 201:3211-3217

Quantification of Abs toward a single epitope is critical to understanding immunobiological processes. In autoimmunity, the prognostic value of the serological profiles of patients draws much attention, but the detection of Abs toward a single epitop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96135a0d4c75554b91114eb8676593bc
https://doi.org/10.4049/jimmunol.1800330

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In ACPA-positive RA patients, antibodies to EBNA35-58Cit, a citrullinated peptide from the Epstein–Barr nuclear antigen-1, strongly cross-react with the peptide β60-74Cit which bears the immunodominant epitope of citrullinated fibrin

Autor: E Verrouil, Alain Cantagrel, Guy Serre, Leonor Nogueira, Martin Cornillet

Publikováno v: Immunologic Research
Immunologic Research, Humana Press, 2015, 61 (1-2), pp.117-125. ⟨10.1007/s12026-014-8584-2⟩

International audience; Although several infectious agents and particularly Epstein-Barr virus (EBV) have been suspected to be involved in aetiology of rheumatoid arthritis (RA), their role still remains elusive. Almost 80% of RA sera contain antibod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a168abba71d1ee0e415025f78bf1c8
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03174485

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The fibrin-derived citrullinated peptide β60–74Cit 60,72,74 bears the major ACPA epitope recognised by the rheumatoid arthritis-specific anticitrullinated fibrinogen autoantibodies and anti-CCP2 antibodies

Autor: Adeline Ruyssen-Witrand, Leonor Nogueira, Ferenc Hudecz, M Cornillet, Anna Magyar, Fruzsina Babos, Alain Cantagrel, Guy Serre, Mireille Sebbag, E Verrouil

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2014, 73 (6), pp.1246-1252. ⟨10.1136/annrheumdis-2012-202868⟩

Objectives To evaluate the proportions of rheumatoid arthritis (RA) sera containing anticitrullinated proteins autoantibodies (ACPA) reactive to α36–50Cit 38,42 and/or β60–74Cit 60,72,74 , two peptides identified as bearing the immunodominant e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3585764dcf2a928c19b3514cf1be60d
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03154569

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The fibrin-derived citrullinated peptide β60-74Cit₆₀,₇₂,₇₄ bears the major ACPA epitope recognised by the rheumatoid arthritis-specific anticitrullinated fibrinogen autoantibodies and anti-CCP2 antibodies

Autor: M, Cornillet, M, Sebbag, E, Verrouil, A, Magyar, F, Babos, A, Ruyssen-Witrand, F, Hudecz, A, Cantagrel, G, Serre, L, Nogueira

Publikováno v: Annals of the rheumatic diseases. 73(6)

To evaluate the proportions of rheumatoid arthritis (RA) sera containing anticitrullinated proteins autoantibodies (ACPA) reactive to α36-50Cit₃₈,₄₂ and/or β60-74Cit₆₀,₇₂,₇₄, two peptides identified as bearing the immunodominant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::715f4b475b5537ebc401d037d60d050b
https://pubmed.ncbi.nlm.nih.gov/23636655

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Prevalence of symptomatic hip and knee osteoarthritis: a two-phase population-based survey

Autor: F, Guillemin, A C, Rat, B, Mazieres, J, Pouchot, B, Fautrel, L, Euller-Ziegler, P, Fardellone, J, Morvan, C H, Roux, E, Verrouil, A, Saraux, J, Coste

Publikováno v: Osteoarthritis and cartilage. 19(11)

Osteoarthritis (OA) epidemiologic data are scarce in Europe. To estimate the prevalence of symptomatic knee and hip OA in a multiregional sample in France.A two-phase population-based survey was conducted in six regions in 2007-2009. On initial phone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a17e4eb0edc870efc9989138b8c1a76a
https://pubmed.ncbi.nlm.nih.gov/21875676

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A5.7 Autoantibodies to the Fibrin-Derived Citrullinated Peptides α36–50 and β60–74 are Two Distinct Non-Overlapping Subfamilies of ACPA that together almost Summarise their Reactivity to Citrullinated Fibrinogen and to CCP2 Antigens

Autor: Alain Cantagrel, Ferenc Hudecz, Adeline Ruyssen-Witrand, Guy Serre, E Verrouil, Mireille Sebbag, Leonor Nogueira, Anna Magyar, M Cornillet

Publikováno v: Annals of the Rheumatic Diseases. 72:A32.2-A32

Objectives To evaluate the proportions of Rheumatoid Arthritis (RA) sera containing autoantibodies to citrullinated proteins (ACPA) reactive to α36–50 and/or β60–74 , two citrullinated peptides identified as bearing the immunodominant epitopes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::409180e80b5e617c95f03b0405fbc92c
https://doi.org/10.1136/annrheumdis-2013-203219.7

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