Zobrazeno 1 - 10
of 37
pro vyhledávání: '"E Vanderwall"'
Autor:
Lei Zhao, Paul Whitehead, Lei Li, Mary Ellen Cvijic, Erica Cook, Akbar M. Siddiqui, Zhuyin Li, Darren Locke, Normand J. Cloutier, Dana E. Vanderwall, Youping Xiao, Larnie Myer, Holmes Derek A, Jia Peng, Richard W. Bishop, Shannon Hamilton
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
Quantitatively determining in vivo achievable drug concentrations in targeted organs of animal models and subsequent target engagement confirmation is a challenge to drug discovery and translation due to lack of bioassay technologies that can discrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9724a7b42ac240a9add9270f93ef94e
http://link.springer.com/article/10.1038/s41598-020-71347-6
http://link.springer.com/article/10.1038/s41598-020-71347-6
Publikováno v:
Drug discovery today. 26(8)
The Allotrope Foundation (AF) is a group of pharmaceutical, device vendor, and software companies that develops and releases technologies [the Allotrope Data Format (ADF), the Allotrope Foundation Ontology (AFO), and the Allotrope Data Models (ADM)]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5ea65e105fea9e7802269299d64670
https://pubmed.ncbi.nlm.nih.gov/33831582
https://pubmed.ncbi.nlm.nih.gov/33831582
Autor:
James R. Brown, Francisco-Javier Gamo, Dana E. Vanderwall, Laura M. Sanz, J.L. Lavandera, Lon R. Cardon, Catherine E. Peishoff, Jose F. Garcia-Bustos, J. Vidal, Vinod Kumar, Emilio Alvarez, Cristina de Cozar, Samiul Hasan, Darren V. S. Green
Publikováno v:
Nature. 465:305-310
Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986d5f9337689f3202160e29365e78b6
https://doi.org/10.1038/nature09107
https://doi.org/10.1038/nature09107
Autor:
Kimberly G. Petrov, Thomas R. Caferro, Octerloney B. McDonald, David W. Rusnak, Dana E. Vanderwall, Kelly Horne Donaldson, Tara Renae Rheault, David E. Uehling, Lisa M. Shewchuk, Scott Howard Dickerson, Robert J. Mullin, Michael D. Gaul, Aaron S. Goetz, Glenn M. Spehar, Anne T. Truesdale, Edgar R. Wood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:817-820
Two new series of potent and selective dual EGFR/ErbB-2 kinase inhibitors derived from novel thienopyrimidine cores have been identified. Isomeric thienopyrimidine cores were evaluated as isosteres for a 4-anilinoquinazoline core and several analogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a62e1d36d5f76869f6a2a75d7237e2
https://doi.org/10.1016/j.bmcl.2008.12.011
https://doi.org/10.1016/j.bmcl.2008.12.011
Autor:
L SALM, J BAX, H VLIEGEN, S LANGERAK, P DIBBETS, J JUKEMA, H LAMB, E PAUWELS, A DEROOS, E VANDERWALL
Publikováno v:
Journal of the American College of Cardiology. 44:1877-1882
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beff96a4b9cfd0ded70216d556b29c64
https://doi.org/10.1016/s0735-1097(04)01617-1
https://doi.org/10.1016/s0735-1097(04)01617-1
Autor:
Marie A. Iannone, John G. Gray, Su Jun Deng, Kenneth H. Pearce, Dana E. Vanderwall, Thomas G. Consler, Catherine A. Simmons, Jean Shearin, Sue H. Kadwell, Daniel L. Svoboda
Publikováno v:
Molecular Endocrinology. 18:1064-1081
Numerous biochemical and structural studies have shown that the conformation of the estrogen receptor alpha (ERalpha) can be influenced by ligand binding. In turn, the conformational state of ERalpha affects the ability of the receptor to interact wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d2b59f816aa91dfe529419bc58c3d2
https://doi.org/10.1210/me.2003-0432
https://doi.org/10.1210/me.2003-0432
Autor:
Dana E. Vanderwall, Anthony M. Paiva, Joanne M. Williamson, Theresa M. Kelly, John W. Kozarich, John S. Blanchard
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1545:67-77
Tuberculosis (TB) remains a leading cause of infectious disease in the world today and therapies developed over the last forty years are becoming increasingly ineffective against resistant strains of Mycobacterium tuberculosis. In an effort to explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58eaff8138b69f7dbc29016712e62b1a
https://doi.org/10.1016/s0167-4838(00)00262-4
https://doi.org/10.1016/s0167-4838(00)00262-4
Autor:
Siu Man Lui, Dana E. Vanderwall, Wei Wu, Christopher J. Turner, John W. Kozarich, JoAnne Stubbe, Xue-Jun Tang
Publikováno v:
Journal of the American Chemical Society. 119:9603-9613
A model for the structure of the aquated form of cobalt bleomycin (H2O-CoBLM or CoBLM A2 brown), free and bound to d(CCAGGCCTGG)2 (1) is reported based on molecular modeling using the constraints obtained from 2D NMR studies. CoBLM A2 brown has a chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be367ab9be2157d3e6f14198f8044399
https://doi.org/10.1021/ja963889l
https://doi.org/10.1021/ja963889l
Publikováno v:
Accounts of Chemical Research. 29:322-330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26fefd0f62631d76980aa185fde62ec4
https://doi.org/10.1021/ar9501333
https://doi.org/10.1021/ar9501333