Zobrazeno 1 - 10
of 225
pro vyhledávání: '"E Van Der Heijden"'
Publikováno v:
eLife, Vol 12 (2024)
The cerebellum contributes to a diverse array of motor conditions, including ataxia, dystonia, and tremor. The neural substrates that encode this diversity are unclear. Here, we tested whether the neural spike activity of cerebellar output neurons is
Externí odkaz:
https://doaj.org/article/1884904f9ba845f7aba263e501abd22a
Autor:
Meike E. van der Heijden, Alejandro G. Rey Hipolito, Linda H. Kim, Dominic J. Kizek, Ross M. Perez, Tao Lin, Roy V. Sillitoe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Insults to the developing cerebellum can cause motor, language, and social deficits. Here, we investigate whether developmental insults to different cerebellar neurons constrain the ability to acquire cerebellar-dependent behaviors. We pertu
Externí odkaz:
https://doaj.org/article/1db2c41322bd4fae9cd9c86194346b9c
Autor:
Kylie Hesp, Jans M. E. van der Heijden, Stephanie Munroe, Detmer Sipkema, Dirk E. Martens, Rene H. Wijffels, Shirley A. Pomponi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The potential of sponge-derived chemicals for pharmaceutical applications remains largely unexploited due to limited available biomass. Although many have attempted to culture marine sponge cells in vitro to create a scalable production plat
Externí odkaz:
https://doaj.org/article/ade6368b29044d5f976d33f6f4798005
Autor:
Jason S. Gill, Megan X. Nguyen, Mariam Hull, Meike E. van der Heijden, Ken Nguyen, Sruthi P. Thomas, Roy V. Sillitoe
Publikováno v:
Dystonia, Vol 2 (2023)
Dystonia is a highly prevalent movement disorder that can manifest at any time across the lifespan. An increasing number of investigations have tied this disorder to dysfunction of a broad “dystonia network” encompassing the cerebellum, thalamus,
Externí odkaz:
https://doaj.org/article/ec8d22ee897248bb980028e5a43388e7
Publikováno v:
Dystonia, Vol 2 (2023)
Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network. There is mounting
Externí odkaz:
https://doaj.org/article/7c16f1cbd34c4921925072763c286563
Publikováno v:
Dystonia, Vol 2 (2023)
Externí odkaz:
https://doaj.org/article/c324ef733e6949d8ac683e3988aec007
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105429- (2022)
Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to t
Externí odkaz:
https://doaj.org/article/f35fbf88bcd64286822aca4340dd8a9d
Autor:
Lauren N. Miterko, Tao Lin, Joy Zhou, Meike E. van der Heijden, Jaclyn Beckinghausen, Joshua J. White, Roy V. Sillitoe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Deep brain stimulation (DBS) has potential for several movement disorders. Here the authors show that DBS improves motor function in a mouse model of ataxia.
Externí odkaz:
https://doaj.org/article/65cc25c011ad4bb78bf25ac8b3f1001d
Autor:
James P. Orengo, Larissa Nitschke, Meike E. van der Heijden, Nicholas A. Ciaburri, Harry T. Orr, Huda Y. Zoghbi
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disorder. As disease progresses, motor neurons are affected, and their dysfunction contributes toward the inability to maintain proper respiratory function, a major driving forc
Externí odkaz:
https://doaj.org/article/81fe3c618f5b464189cef1cacb8d4ffe
Autor:
Rosanne M. Smits, Dieuwke S. Veldhuijzen, Henriët van Middendorp, Marianne J. E. van der Heijden, Monique van Dijk, Andrea W. M. Evers
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2022)
Objectives: Placebo effects, beneficial treatment outcomes due to non-active treatment components, play an important role in the overall treatment response. To facilitate these beneficial effects it is important to explore the perspectives of health
Externí odkaz:
https://doaj.org/article/6ae26137b118402a95e4eb093013aeab