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Application of the comprehensive analysis of pollution of the Kacha river by oil products in the information and analytical system

Autor: E M Gritsenko, E V Lis, E N Voronchikhina, A A Popov

Publikováno v: Journal of Physics: Conference Series. 2094:052003

This article examines the analysis of the concentration of oil products depending on the anthropogenic impact on water quality in the Kacha River. As part of the work, the regularities of the dynamics of changes in the concentration of oil products i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bea73c1d6809b31bc8f65dc1130d04ad
https://doi.org/10.1088/1742-6596/2094/5/052003

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Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes

Autor: Armando Lagrutta, Maria I. Roman, Haoyu Zeng, E V Lis, Frederick Sannajust

Publikováno v: Journal of Pharmacological and Toxicological Methods. 81:217-222

FDSS/μCell is a high-speed acquisition imaging platform (Hamamatsu Ltd., Hamamatsu, Japan) that allows for simultaneous high-throughput reading under controlled conditions. We evaluated the Ca 2 + transients or optical membrane potential changes of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0562e349143aeb72cd279f94112f12c6
https://doi.org/10.1016/j.vascn.2016.05.009

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Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells

Autor: Bharathi Balasubramanian, Armando Lagrutta, Spencer Dech, Haoyu Zeng, Joseph J. DeGeorge, Jin Zhai, Jixin Wang, Frederick Sannajust, E V Lis, John P. Imredy

Publikováno v: Toxicology and applied pharmacology. 308

Several clinical cases of severe bradyarrhythmias have been reported upon co-administration of the Hepatitis-C NS5B Nucleotide Polymerase Inhibitor (HCV-NI) direct-acting antiviral agent, sofosbuvir (SOF), and the Class-III anti-arrhythmic amiodarone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed3e25dfca781ceed0ed5ec947be38e
https://pubmed.ncbi.nlm.nih.gov/27520758

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Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment

Autor: Bharathi Balasubramanian, Li Leyna Zhao, Armando Lagrutta, Stephen L. White, Yama A. Abassi, Liang Guo, Frederick Sannajust, E V Lis, Myrtle Davis, Xiaobo Wang, Xiaoyu Zhang, Michael Furniss, Haoyu Zeng, Biao Xi

Publikováno v: Journal of pharmacological and toxicological methods. 81

Introduction The ICH S7B guidelines recommend that all new chemical entities should be subjected to hERG repolarization screening due to its association with life-threatening “Torsades de Pointes” (TdP) arrhythmia. However, it has become evident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fb5df0bc98c79a907fb8873195fe14
https://pubmed.ncbi.nlm.nih.gov/27282640

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Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists

Publikováno v: ACS Chemical Neuroscience. 2:352-362

A series of 3-substituted aminocyclopentanes has been identified as highly potent and selective NR2B receptor antagonists. Incorporation of a 1,2,4-oxadiazole linker and substitution of the pendant phenyl ring led to the discovery of orally bioavaila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2684ec1a091b2da7e8fdaae9487129
https://doi.org/10.1021/cn200013d

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Group III Metabotropic Glutamate Receptor-Mediated Modulation of the Striatopallidal Synapse

Autor: Michael J. Marino, P. Jeffrey Conn, Gene G. Kinney, Ornella Valenti, E V Lis, Marion Wittmann, Anthony G. DiLella

Publikováno v: The Journal of Neuroscience. 23:7218-7226

The globus pallidus (GP) is a key GABAergic nucleus in the basal ganglia (BG). The predominant input to the GP is an inhibitory striatal projection that forms the first synapse in the indirect pathway. The GP GABAergic neurons project to the subthala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf52171699aea8a09ce232cc27823a33
https://doi.org/10.1523/jneurosci.23-18-07218.2003

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Benzodiazepines as Potent and Selective Bradykinin B1 Antagonists

Publikováno v: Journal of Medicinal Chemistry. 46:1803-1806

Antagonism of the bradykinin B(1) receptor was demonstrated to be a potential treatment for chronic pain and inflammation. Novel benzodiazepines were designed that display subnanomolar affinity for the bradykinin B(1) receptor (K(i) = 0.59 nM) and hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4339898a624691ea9cc43463fa84f9b0
https://doi.org/10.1021/jm034020y

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