Zobrazeno 1 - 4
of 4
pro vyhledávání: '"E V, Rukavishnikova"'
Publikováno v:
Patologicheskaia fiziologiia i eksperimental'naia terapiia. (4)
Human 125I-acyaloorosomucoid was intravenously injected to male Wistar rats. Hepatic cirrhosis was induced by oily CCl4 solution (0.04 ml toxin per 100 g body weight, twice a week for 2 months). Cirrhosis was found not to prevent blood elimination of
Publikováno v:
Biological chemistry Hoppe-Seyler. 373(7)
The lysosomotropic agent chloroquine is widely used as a specific inhibitor of intralysosomal proteolysis in isolated hepatocytes. It was shown that in vitro chloroquine reversibly inhibited purified cathepsins H, B, L in concentrations less than tho
Publikováno v:
Acta biologica Hungarica. 42(1-3)
1. Chloroquine accumulation in rat liver after a single and repeated drug administration and lysosomal changes resembling some symptoms of lysosomal storage diseases were observed. 2. Repeated chloroquine treatment of rats resulted in increased activ
Publikováno v:
Voprosy meditsinskoi khimii. 36(6)
Effects of single and repeated injections of lysosomotropic agent chloroquine on lysosomal proteolytic activity and physico-chemical properties of rat liver lysosomes have been studied. Chloroquine was administered intraperitoneally to rats at a dose