Výsledky vyhledávání - "E V, Kugaevskaia"

[Key enzymes of degradation and angiogenesis as a factors of tumor progression in squamous cell carcinoma of the cervix]

Autor: N I, Solov'eva, O S, Timoshenko, E V, Kugaevskaia, Iu Iu, Andreeva, L E, Zavalishina

Publikováno v: Bioorganicheskaia khimiia. 40(6)

A key role in tumor progression play two processes--the destruction and angiogenesis. Matrix metalloproteases (MMPs) play a leading role during tissue degradation. Tissue collagenase--MMP-1 and MT1-MMP hydrolyze fibrillar collagens, which are the bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d44c400670ec6d30bbe2cebe0f0d656
https://pubmed.ncbi.nlm.nih.gov/25895371

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[Angiotensin converting enzyme and Alzheimer's disease]

Autor: E V, Kugaevskaia

Publikováno v: Biomeditsinskaia khimiia. 59(1)

Alzheimer's disease (AD) is an incurable degenerative disease of the central nervous system, leading to dementia. The basis of AD is neurodegenerative process that leads to death of neurons in the cerebral cortex. This neurodegenerative process is as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55df8afbf078b912586e02eaf97ab0d4
https://pubmed.ncbi.nlm.nih.gov/23650720

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[ACE inhibitors--activators of kinin receptors]

Autor: E V, Kugaevskaia, Iu E, Eliseeva

Publikováno v: Biomeditsinskaia khimiia. 57(3)

Angiotensin converting enzyme (ACE) inhibitors are widely used for treatment of cardiovascular diseases. The effects of ACE inhibitors on the human bradykinin receptors were investigated. The mode of action of ACE inhibitors is considered. There is e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3a1e705fe5ae46a49eb85200bccf050
https://pubmed.ncbi.nlm.nih.gov/21863742

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[Structure and physiological significance of angiotensin converting enzyme domains]

Autor: Iu E, Eliseeva, E V, Kugaevskaia

Publikováno v: Biomeditsinskaia khimiia. 55(4)

Somatic angiotensin converting enzyme (ACE) consists of two homologous catalytic domains (N- and C-domain), each of which bears an active site exhibiting different biochemical properties. The ACE isoforms consisted of one domain were also detected in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7677291ae017443ec10a74e9424997e3
https://pubmed.ncbi.nlm.nih.gov/20000120

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[Angiotensin converting enzyme domain structure and properties]

Autor: E V, Kugaevskaia

Publikováno v: Biomeditsinskaia khimiia. 51(6)

Angiotensin converting enzyme (ACE) is a key enzyme of the renin-angiotensin and kallikrein-kinin systems responsible for the regulation of blood pressure. Recently the new physiological function of ACE has been revealed: the enzyme hydrolyses in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51e40ea6d064e13955ccbb56978a3630
https://pubmed.ncbi.nlm.nih.gov/16521820

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[Participation of serine proteinases in transforming the high molecular weight (600 kDa) form of angiotensin 1-converting enzyme into the low molecular weight form (190 kDa)]

Autor: E V, Kugaevskaia, L V, Pavlikhina, Iu E, Eliseeva

Publikováno v: Voprosy meditsinskoi khimii. 40(3)

A high molecular form of angiotensin-converting enzyme with mol mass about 600 kDa was found simultaneously with the well-known low molecular enzyme form of 190 kDa after fractionation of freshly prepared extracts from bovine kidney cortex and lung t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::322b5b0930bc0a9dc3973e283b462193
https://pubmed.ncbi.nlm.nih.gov/8079446

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[Inhibition of the angiotensin-converting enzyme from bovine kidney by organophosphorus analogs of amino acids]

Autor: V V, Shumiantseva, I A, Gandurina, T I, Osipova, E V, Kugaevskaia

Publikováno v: Voprosy meditsinskoi khimii. 36(4)

Reactions of amino acid phosphoorganic derivatives with angiotensin-converting enzyme (dipeptidyl carboxypeptidase) were studied. Substitution of the amino acid carboxyl group by HS- or P(O) (OH)2-groups did not cause the enzyme considerable inhibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c3a59daede4fb8ef84c7d775be2e046
https://pubmed.ncbi.nlm.nih.gov/2238538

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[Bradykinin-potentiating peptides from the spider Latrodectus tredecimguttatus--inhibitors of carboxycathepsin and of a preparation of karakurt venom kininase]

Autor: N A, Sosnina, Z, Golubenko, A A, Akhunov, E V, Kugaevskaia, Iu E, Eliseeva, V N, Orekhovich

Publikováno v: Doklady Akademii nauk SSSR. 315(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::227811086634ea0cc2b1cdf5fe123897
https://pubmed.ncbi.nlm.nih.gov/1965800

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[Induction of blood plasma carboxycathepsin (angiotensin I-converting enzyme) in normo- and hypertensive rats in response to a single administration of captopril]

Autor: E V, Kugaevskaia, Iu E, Eliseeva, L V, Pavlikhina, V N, Orekhovich, I F, Faermark

Publikováno v: Biulleten' eksperimental'noi biologii i meditsiny. 103(1)

The experiments were carried out to elucidate the effect of carboxycathepsin (CC) activity inhibition by a specific inhibitor--captopril--on plasma enzyme concentration in normotensive rats and rats with renovascular hypertension. A single oral admin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae4a1c0014d6fc34ff417593b923e087
https://pubmed.ncbi.nlm.nih.gov/3026518

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