The genomic epidemiology of shigellosis in South Africa

Autor: George E. Stenhouse, Karen H. Keddy, Rebecca J. Bengtsson, Neil Hall, Anthony M. Smith, Juno Thomas, Miren Iturriza-Gómara, Kate S. Baker

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Shigellosis, a leading cause of diarrhoeal mortality and morbidity globally, predominantly affects children under five years of age living in low- and middle-income countries. While whole genome sequence analysis (WGSA) has been effectively

Externí odkaz: https://doaj.org/article/8a1c9927a4c8493ba55330c04e7144f1

A tale of two plasmids: contributions of plasmid associated phenotypes to epidemiological success among Shigella

Autor: P. Malaka De Silva, George E. Stenhouse, Grace A. Blackwell, Rebecca J. Bengtsson, Claire Jenkins, James P.J. Hall, Kate S. Baker

Publikováno v: Proceedings of the Royal Society B: Biological Sciences. 289

Dissemination of antimicrobial resistance (AMR) genes by horizontal gene transfer (HGT) mediated through plasmids is a major global concern. Genomic epidemiology studies have shown varying success of different AMR plasmids during outbreaks, but the u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de158b2a05f8420b4772851ff8809e5c
https://doi.org/10.1098/rspb.2022.0581

Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa

Autor: Rebecca J. Bennett, Melita A. Gordon, Rebecca J. Bengtsson, Mike P. Mautanga, Neil Hall, Jessica A. Bevington, Xiaojun Zhu, Alexandra Beliavskaia, P. Malaka De Silva, Arthur Bowers-Barnard, Kate S. Baker, Benjamin Kumwenda, Jay C. D. Hinton, Hermione J. Webster, François-Xavier Weill, George E. Stenhouse, Blanca M. Perez-Sepulveda, Happy C. Banda, Nicholas A. Feasey, Will P. M. Rowe, Reenesh Prakash, Ella V. Rodwell, Alexander V. Predeus, Caisey V. Pulford, Nicolas Wenner, Amy Dumigan, José A. Bengoechea, Alistair C. Darby, Rocío Canals, Alicia Tran-Dien, Lovemore Alufandika

Publikováno v: Nature Microbiology
Pulford, C V, Perez-Sepulveda, B M, Canals, R, Bevington, J A, Bengtsson, R J, Wenner, N, Rodwell, E V, Kumwenda, B, Zhu, X, Bennett, R J, Stenhouse, G E, Malaka De Silva, P, Webster, H J, Bengoechea, J A, Dumigan, A, Tran-Dien, A, Prakash, R, Banda, H C, Alufandika, L, Mautanga, M P, Bowers-Barnard, A, Beliavskaia, A Y, Predeus, A V, Rowe, W P M, Darby, A C, Hall, N, Weill, F X, Gordon, M A, Feasey, N A, Baker, K S & Hinton, J C D 2021, ' Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa ', Nature Microbiology, vol. 6, no. 3, pp. 327-338 . https://doi.org/10.1038/s41564-020-00836-1

Bloodstream infections caused by nontyphoidal Salmonella are a major public health concern in Africa, causing ~49,600 deaths every year. The most common Salmonella enterica pathovariant associated with invasive nontyphoidal Salmonella disease is Salm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a49e6ff039ac94bfb81b219ce79cab4
https://doi.org/10.1038/s41564-020-00836-1

Accessory Genome Dynamics and Structural Variation of Shigella from Persistent Infections

Autor: Timothy J. Dallman, P. Malaka De Silva, Rebecca J. Bennett, George E. Stenhouse, Claire Jenkins, Caisey V. Pulford, Kate S. Baker, Hester Allen, Rebecca J. Bengtsson

Publikováno v: Bengtsson, R J, Dallman, T J, Allen, H, De Silva, P M, Stenhouse, G, Pulford, C V, Bennett, R J, Jenkins, C & Baker, K S 2021, ' Accessory Genome Dynamics and Structural Variation of Shigella from Persistent Infections ', mBio, vol. 12, no. 2 . https://doi.org/10.1128/mBio.00254-21
mBio, 12(2), 1. American Society for Microbiology
mBio
mBio, Vol 12, Iss 2 (2021)

Shigella spp. are Gram-negative bacteria that are the etiological agent of shigellosis, the second most common cause of diarrheal illness among children under the age of five in low-income countries. In high-income countries, shigellosis is also a se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d5161853c9c4109af91148a9dcb61b
https://www.pure.ed.ac.uk/ws/files/207697248/mBio_2021_Bengtsson_e00254_21.full.pdf

P92 Management of congenital lung malformations in a novel combined medical and surgical service

Autor: J Coutts, T Bradnock, E Stenhouse, A Sabharwal, L Thomson

Publikováno v: Pick and mix: paediatric lung disease.

Introduction Fetal anomaly scanning (FAS) increases the diagnosis of congenital lung malformations (CLMs). Uncertainty exists regarding best management; conservative versus elective removal. CLM cases following routine FAS introduction in our region

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30dd00b67ec0c65e6fa9ee9821b021ad
https://doi.org/10.1136/thorax-2018-212555.250