IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis

Autor: Michael J. Ombrello, Dirk Foell, Sara Marchesan Oliveira, P Woo, Jordi Anton, Alberto Martini, Andrew Zeft, Lucy R. Wedderburn, Sampath Prahalad, Alan M. Rosenberg, DL Kastner, Kirsten Minden, John F. Bohnsack, Ricardo Russo, E Shuldiner, Yeung Rsm, Anne Hinks, Elaine F. Remmers, Seza Ozen, J.-P. Haas, Angela Rösen-Wolff, Arthur Vl, Wendy Thomson, Ann Marie Szymanski, Norman T. Ilowite, Claudio Arnaldo Len, Elizabeth D. Mellins, A. Grom, Marco Gattorno

Publikováno v: ARTHRITIS & RHEUMATOLOGY
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Arthur, V L, Shuldiner, E, Remmers, E F, Hinks, A, Grom, A A, Foell, D, Martini, A, Gattorno, M, Özen, S, Prahalad, S, Zeft, A S, Bohnsack, J F, Ilowite, N T, Mellins, E D, Russo, R, Len, C, Oliveira, S, Yeung, R S M, Rosenberg, A M, Wedderburn, L R, Anton, J, Haas, J, Rösen-wolff, A, Minden, K, Szymanski, A M, Thomson, W, Kastner, D L, Woo, P & Ombrello, M J 2018, ' IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis ', Arthritis & Rheumatology (Hoboken), vol. 70, no. 8, pp. 1319-1330 . https://doi.org/10.1002/art.40498

OBJECTIVE: To determine whether systemic juvenile idiopathic arthritis (JIA) susceptibility loci that were identified by candidate gene studies demonstrate association with systemic JIA in the largest study population assembled to date. METHODS: Sing

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Enrichment of Rare Variants of Hemophagocytic Lymphohistiocytosis Genes in Systemic Juvenile Idiopathic Arthritis.

Autor: Marques MC; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA., Rubin D; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA., Shuldiner E; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA., Datta M; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA., Schmitz E; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA., Cruz GG; Genomic Technology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA., Patt A; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA., Bennett E; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA., Grom A; Rheumatology, Cincinnati Children`s Hospital Medical Center, Cincinnati, USA., Foell D; Department of Pediatric Rheumatology and Immunology, University Hospital Muenster, Muenster, Germany., Gattorno M; Unit Rheumatology and Autoinflammatory Diseases, IRCCS Istituto G. Gaslini, Genoa, Italy., Bohnsack J; Department of Pediatrics, University of Utah Eccles School of Medicine, Salt Lake City, USA., Yeung RSM; The Hospital for Sick Children, University of Toronto, Toronto, Canada., Prahalad S; Emory University school of Medicine, Atlanta, USA.; Children's Healthcare of Atlanta, Atlanta, USA., Mellins E; Department of Pediatrics, Program in Immunology, Stanford University, Stanford, USA., Anton J; Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain., Len CA; São Paulo Federal University, São Paulo, Brazil., Oliveira S; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Woo P; University College London, London, UK., Ozen S; Department of Pediatrics, Hacettepe University, Ankara, Turkey., Deng Z; Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA., Ombrello MJ; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Mar 15. Date of Electronic Publication: 2024 Mar 15.