Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation.

Autor: Sam C Nalle, Rosa Barreira da Silva, Hua Zhang, Markus Decker, Cecile Chalouni, Min Xu, George Posthuma, Ann de Mazière, Judith Klumperman, Adriana Baz Morelli, Sebastian J Fleire, Alan S Verkman, E Sergio Trombetta, Matthew L Albert, Ira Mellman

Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0238484 (2020)

Antigen cross presentation, whereby exogenous antigens are presented by MHC class I molecules to CD8+ T cells, is essential for generating adaptive immunity to pathogens and tumor cells. Following endocytosis, it is widely understood that protein ant

Externí odkaz: https://doaj.org/article/94af70eb40954a77a1d3ec9f2e7824fe

Supplementary Figures S1-S4 from Anti-KIT Monoclonal Antibody Treatment Enhances the Antitumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression

Autor: Richard Gedrich, Theresa M. LaVallee, Shannon Pankratz, E. Sergio Trombetta, Sreekala Mandiyan, Neal Janson, Linda Crew, Lori Lopresti-Morrow, Scott Seibel, Andrew J. Garton

Supplemental Figure S1A - Gating Plot Example for Identification of MDSC Populations in Spleen Samples (Pan02 Study); Supplemental Figure S1B - Gating Plot Example for Identification of T-Cell Populations in Tumor Samples (Pan02 Study); Supplemental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34945b0a4833e192ab76515e29437792
https://doi.org/10.1158/1535-7163.22507465

Data from Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas

Autor: Ruth Halaban, Gregory E. Hannigan, Kazuaki Yoshikawa, Michio Niinobe, Terence Wu, E. Sergio Trombetta, Elaine Cheng, Aaron J. Berger, Harriet M. Kluger, Aiping Lin, Stephan Ariyan, Hongyu Zhao, Kenneth R. Williams, David L. Rimm, Keith Hoek

Affymetrix and spotted oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310810d868b6792ede2c2b029597843d
https://doi.org/10.1158/0008-5472.c.6493784.v1

Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance

Autor: Riad Abes, Kevin Biteau, Alexandre Glémain, Christophe Blanquart, Dominique Costantini, Catherine Ruiz, David Laplaud, Hélène Aublé, Stéphanie Le Bas-Bernardet, E. Sergio Trombetta, Véronique Catros, Gilles Blancho, Isabelle Archambeaud, Sylvie Métairie, Isabelle Girault, Emmanuelle Wilhelm, Masayuki Miyasaka, Jean-François Mosnier, Vanessa Gauttier, Sabrina Pengam, Charlène Trilleaud, Alexandra Garcia, Pierre-Antoine Gouraud, Pierre Duplouye, Bernard Martinet, Géraldine Teppaz, Georgia Porto, Fabienne Haspot, Sarah Bruneau, Aurore Morello, Justine Durand, Caroline Mary, Richard Danger, Sophie Conchon, Nathalie Labarrière, Kerry L. M. Ralph, Virginie Thepenier, Nicolas Vince, Nicolas Poirier, Bernard Vanhove, Virginie Vignard, Mélanie Néel, Safa Dehmani

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2020, 130 (11), pp.6109-6123. ⟨10.1172/JCI135528⟩
Journal of Clinical Investigation, 2020, 130 (11), pp.6109-6123. ⟨10.1172/JCI135528⟩
J Clin Invest

International audience; T cell exclusion causes resistance to cancer immunotherapies via immune checkpoint blockade (ICB). Myeloid cells contribute to resistance by expressing signal regulatory protein-α (SIRPα), an inhibitory membrane receptor tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19a5d1d3edf746100f79d51f25bf360
https://doi.org/10.1172/jci135528

Anti-KIT Monoclonal Antibody Treatment Enhances the Antitumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression

Autor: Lori Lopresti-Morrow, Theresa LaVallee, Andrew Garton, E. Sergio Trombetta, Shannon Pankratz, Linda Crew, Neal Janson, Richard Gedrich, Scott Seibel, Sreekala Mandiyan

Publikováno v: Molecular cancer therapeutics. 16(4)

The receptor tyrosine kinase KIT is an established oncogenic driver of tumor growth in certain tumor types, including gastrointestinal stromal tumors, in which constitutively active mutant forms of KIT represent an actionable target for small-molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562d1285cd08a95537e834b8d69e882f
https://pubmed.ncbi.nlm.nih.gov/28138031