Development of SARS-CoV-2 mRNA vaccines encoding spike N-terminal and receptor binding domains

Autor: Guillaume B.E. Stewart-Jones, Sayda M. Elbashir, Kai Wu, Diana Lee, Isabella Renzi, Baoling Ying, Matthew Koch, Caralyn E. Sein, Angela Choi, Bradley Whitener, Dario Garcia-Dominguez, Carole Henry, Angela Woods, LingZhi Ma, Daniela Montes Berrueta, Laura E. Avena, Julian Quinones, Samantha Falcone, Chiaowen J. Hsiao, Suzanne M. Scheaffer, Larissa B. Thackray, Phil White, Michael S. Diamond, Darin K. Edwards, Andrea Carfi

Publikováno v: bioRxiv

With the success of mRNA vaccines against coronavirus disease 2019 (COVID-19), strategies can now focus on improving vaccine potency, breadth, and stability. We present the design and preclinical evaluation of domain-based mRNA vaccines encoding the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe8958c3e87fbf6d9c9bca9931512ac
https://europepmc.org/articles/PMC9558437/

Photoactivatable Glycolipid Probes for Identifying Mycolate–Protein Interactions in Live Mycobacteria

Autor: Yasu S. Morita, Benjamin M. Swarts, M. Sloan Siegrist, Herbert W. Kavunja, Kyle J. Biegas, Jessica M. Groenevelt, Brent F. Piligian, Jessica A. Stewart, Caralyn E Sein, Nicholas Banahene, Michael Niederweis

Publikováno v: J Am Chem Soc

Mycobacteria have a distinctive glycolipid-rich outer membrane, the mycomembrane, which is a critical target for tuberculosis drug development. However, proteins that associate with the mycomembrane, or that are involved in its metabolism and host in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e154f0473c65ff37f47e6404e43a99e
https://doi.org/10.1021/jacs.0c01065

Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice

Autor: Baoling Ying, Suzanne M. Scheaffer, Bradley Whitener, Chieh-Yu Liang, Oleksandr Dmytrenko, Samantha Mackin, Kai Wu, Diana Lee, Laura E. Avena, Zhenlu Chong, James Brett Case, LingZhi Ma, Thu T.M. Kim, Caralyn E. Sein, Angela Woods, Daniela Montes Berrueta, Gwo-Yu Chang, Guillaume Stewart-Jones, Isabella Renzi, Yen-Ting Lai, Agata Malinowski, Andrea Carfi, Sayda M. Elbashir, Darin K. Edwards, Larissa B. Thackray, Michael S. Diamond

Publikováno v: Cell. 185:1572-1587.e11

The large number of spike substitutions in Omicron lineage variants (BA.1, BA.1.1., and BA.2) could jeopardize the efficacy of SARS-CoV-2 vaccines. We evaluated in mice the protective efficacy of the Moderna mRNA-1273 vaccine against BA.1 before or a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2cab04fcf9feeba5833021ceb23a1d
https://doi.org/10.1016/j.cell.2022.03.037

The mycobacterial cell wall partitions the plasma membrane to organize its own synthesis

Autor: Alam García-Heredia, Sarah H Osman, Yasu S. Morita, Julia Puffal, Todd A. Gray, Julius Judd, Caralyn E Sein, Takehiro Kado, Siegrist Ms

Many antibiotics target the assembly of cell wall peptidoglycan, an essential, heteropolymeric mesh that encases most bacteria. Different species have characteristic subcellular sites of peptidoglycan synthesis that they must carefully maintain for s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1e4aea3d56f7d2ddbee19265fc60e53
https://doi.org/10.1101/544338

Outcome of appendicectomy in children performed in paediatric surgery units compared with general surgery units

Autor: S Tiboni, A Bhangu, N J Hall, I G Panagiotopoulou, N Chatzizacharias, M Rana, K Rollins, F Ejtehadi, B Jha, Y-W Tan, N Fanous, G Markides, A Tan, C Marshal, S Akhtar, D Mullassery, A Ismail, C Hitchins, S P Sharif, L Osborne, N Sengupta, C Challand, D Pournaras, K Bevan, J King, J Massey, I Sandhu, J M Wells, D A Teichmann, A Peckham-Cooper, M Sellers, S E Folaranmi, B Davies, S P Loukogeorgakis, R Kalaiselvan, S Marzouk, E J H Turner, S Kaptanis, V Kaur, G Shingler, A Bennett, M Aly, J Coad, T Khong, Z Nouman, J Crawford, P Szatmary, H West, A L MacDonald, K A Hanks, E Griggs, L Humphreys, A Torrance, J Hardman, L Taylor, D Rex, J Bennett, N Crowther, B McAree, S Flexer, P Mistry, P Jain, M Hwang, N Oswald, A Wells, H Newsome, A Campbell, D Carradice, R Gohil, M Mount, S Iype, E Dyson, T Groot-Wassink, A R Ross, C Jones, N Baylem, J Voll, T Sian, L Creedon, P Charlesworth, J Goring, V Ng, T Palser, B Rees, P Ravindra, C Neophytou, H Dent, T Lo, L Broom, M O'Connell, R Foulkes, D Griffith, K Butcher, O Mclaren, A Tai, H D T Torrance, O Moussa, D Mittapalli, D Watt, S Basson, A Wilkins, J Yee, H Cain, M Wilson, J Pearson, E Turnbull, A Brigic, N A Yassin, J Clarke, S Mallappa, P Jackson, C E Jones, B Lakshminarayanan, K Fareed, G Yip, A Brown, N Patel, M Ghisel, N Tanner, H Jones, J Witherspoon, M Phillips, W K Mitchell, F Amawi, E Dickson, S Aggarwal, L K Satherley, F Asprou, C Keys, M Steven, J Muhlschlegel, E Hamilton, J Yin, M Dilworth, A Wright, P Spreadborough, M Singh, K Mockford, J Morgan, W Ball, J Royle, J Lacy-Colson, C Batterbsy, C A Hateley, A Penkethman, C Lambden, W Lai, S Griffiths, S Mitchell, C Parsons, A Conway, P Dent, D Yacob, C Tennuci, N Battersby, R Wilkin, C Lloyd, E Sein, K McEvoy, L Whisker, S Austin, A Colori, P Sinclair, M Loughran, A Lawrence, A Pisesky, S Mastoridis, K Solanki, I Siddiq, L Merker, P Sarmah, C Richardson, T Pinkney, C Battersby, D Beral, J Cornish, S Strong, R Velineni

Publikováno v: British Journal of Surgery. 101:707-714

Background Appendicectomy for acute appendicitis in children may be performed in specialist centres by paediatric surgeons or in general surgery units. Service provision and outcome of appendicectomy in children may differ between such units. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43acebb0eb22ee3561279fed05302c1
https://doi.org/10.1002/bjs.9455