Výsledky vyhledávání - "E Schiffmann"

Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor

Autor: S W, Nam, T, Clair, Y S, Kim, A, McMarlin, E, Schiffmann, L A, Liotta, M L, Stracke

Publikováno v: Cancer research. 61(18)

Autotaxin [ATX (NPP-2)], originally isolated as a tumor motility-stimulating protein, has recently been shown to augment tumor aggressiveness. Specifically, atx-transfected, ras-transformed NIH3T3 cell lines have been shown to be more invasive, tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3dc1981eaa4d975c5623b49678e98f23
https://pubmed.ncbi.nlm.nih.gov/11559573

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A sensitive screening assay for secreted motility-stimulating factors

Autor: S W, Nam, T, Clair, E, Schiffmann, L A, Liotta, M L, Stracke

Publikováno v: Cell motility and the cytoskeleton. 46(4)

Secreted motility-stimulating factors are often expressed and secreted at low concentrations that are difficult to detect by Northern or Western blot analysis. Autotaxin (ATX) is a tumor-secreted autocrine motility-stimulating factor that has been as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f53e6d9666de912fccb9eff86d6b024
https://pubmed.ncbi.nlm.nih.gov/10962482

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Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase

Autor: P T, Mulvaney, M L, Stracke, S W, Nam, E, Woodhouse, M, O'Keefe, T, Clair, L A, Liotta, R, Khaddurah-Daouk, E, Schiffmann

Publikováno v: International journal of cancer. 78(1)

Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine), an analog of creatine and a substrate for creatine kinase (EC 2.7.3.2), inhibits the stimulated motility of tumor cells which possess creatine kinase. A2058-055 human melanoma cells, transfected w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07bc7078362da7bf7076a48d132e8a12
https://pubmed.ncbi.nlm.nih.gov/9724093

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The role of autotaxin and other motility stimulating factors in the regulation of tumor cell motility

Autor: M, Stracke, L A, Liotta, E, Schiffmann

Publikováno v: Symposia of the Society for Experimental Biology. 47

Active cellular motility is required for tumor cell penetration of the basement membrane and the interstitial stroma during the transition from in situ to invasive carcinoma. Multiple factors, both autocrine and paracrine in origin, appear to influen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::879a8465ccd8eb29b86c1ba050ea38e3
https://pubmed.ncbi.nlm.nih.gov/8165565

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Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein

Autor: M L, Stracke, H C, Krutzsch, E J, Unsworth, A, Arestad, V, Cioce, E, Schiffmann, L A, Liotta

Publikováno v: The Journal of biological chemistry. 267(4)

Autotaxin (ATX) is a potent human motility-stimulating protein that has been identified in the conditioned medium from A2058 melanoma cells. This protein has been purified to homogeneity utilizing a strategy involving five column steps. Homogeneity o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5359f4f6d339673d7917b711b1064e61
https://pubmed.ncbi.nlm.nih.gov/1733949

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Tumor cell motility

Autor: L A, Liotta, M L, Stracke, S A, Aznavoorian, M E, Beckner, E, Schiffmann

Publikováno v: Seminars in cancer biology. 2(2)

Tumor cell motility is required for invasion and metastasis. The locomotory machinery of the cell includes cell projections called pseudopodia which are regulated by a complicated linkage between cell surface receptors or sensors and the internal cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5aa6bc933f69b30d4e8a3add72abf68
https://pubmed.ncbi.nlm.nih.gov/1912521

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Cell motility, a principal requirement for metastasis

Autor: M L, Stracke, S A, Aznavoorian, M E, Beckner, L A, Liotta, E, Schiffmann

Publikováno v: EXS. 59

In studying the role of motility in the metastasis of tumor cells, we have described an autocrine motility factor. This agent, which stimulates random motility, probably contributes to the initial dissociation of the cells from the primary tumor mass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4cf1b3abfe66f0e6fb437975c0dc8284
https://pubmed.ncbi.nlm.nih.gov/1833227

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