Zobrazeno 1 - 10
of 2 033
pro vyhledávání: '"E Scherer"'
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S881- (2023)
Objetivos: Descrever o perfil das consultas farmacêuticas realizadas com pacientes do Serviço de Hematologia em uso de quimioterapia oral, que foram atendidos pela Farmácia de Medicamentos Especiais (FME) de um hospital de grande porte de Porto Al
Externí odkaz:
https://doaj.org/article/d52d5e6d27234127954f429910713d7a
Autor:
Paul M. Cinciripini, David W. Wetter, Jian Wang, Robert Yu, George Kypriotakis, Tapsi Kumar, Jason D. Robinson, Yong Cui, Charles E. Green, Andrew W. Bergen, Thomas R. Kosten, Steven E. Scherer, Sanjay Shete
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Despite the large public health toll of smoking, genetic studies of smoking cessation have been limited with few discoveries of risk or protective loci. We investigated common and rare variant associations with success in quitting smoking us
Externí odkaz:
https://doaj.org/article/7508837f9caa4e14ad97cc6863aab246
Autor:
Paul C. Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H. Burks, Junedh Amrute, Jared S. Elenbaas, Chul Joo Kang, Erica P. Young, Philipp E. Scherer, Nathan O. Stitziel
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110104- (2024)
Summary: Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic
Externí odkaz:
https://doaj.org/article/f1c5ae12bdf0423691d81d9943e37603
Autor:
Yi Zhu, Na Li, Mingyang Huang, Xi Chen, Yu A. An, Jianping Li, Shangang Zhao, Jan-Bernd Funcke, Jianhong Cao, Zhenyan He, Qingzhang Zhu, Zhuzhen Zhang, Zhao V. Wang, Lin Xu, Kevin W. Williams, Chien Li, Kevin Grove, Philipp E. Scherer
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 7, Pp 3063-3072 (2022)
Adipose tissue is a promising target for treating obesity and metabolic diseases. However, pharmacological agents usually fail to effectively engage adipocytes due to their extraordinarily large size and insufficient vascularization, especially in ob
Externí odkaz:
https://doaj.org/article/9f7116cbe4124a1d906ae08cbc4f4d5c
Autor:
Alex B. Smith, Jonah P. Schill, Ruth Gordillo, Grace E. Gustafson, Timothy W. Rhoads, Maggie S. Burhans, Aimee T. Broman, Ricki J. Colman, Philipp E. Scherer, Rozalyn M. Anderson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Metabolic syndrome increases risk of complicating co-morbidities. Current clinical indicators reflect established metabolic impairment, preventing earlier intervention strategies. Here we show that circulating sphingolipids are altered in th
Externí odkaz:
https://doaj.org/article/43f3986a7da74abcbd070096cce668a7
Autor:
Zhenzhen Zi, Zhuzhen Zhang, Qiang Feng, Chiho Kim, Xu-Dong Wang, Philipp E. Scherer, Jinming Gao, Beth Levine, Yonghao Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
mTORC1, central regulator of cell growth and autophagy suppressor, is activated on the lysosome surface, but its local role in lysosomal biology remains unclear. Here the authors show STK11IP is a substrate of mTORC1 that regulates lysosomal acidific
Externí odkaz:
https://doaj.org/article/b73a4c77238140d09f96cfc934dc20ef
Autor:
Dae-Seok Kim, Philipp E. Scherer
Publikováno v:
Diabetes & Metabolism Journal, Vol 45, Iss 6, Pp 799-812 (2021)
Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that obesity and diabetes are associated with an increased risk
Externí odkaz:
https://doaj.org/article/27e76c839ca846129a8ef51a3ef5116d
Autor:
Yi Zhu, Na Li, Mingyang Huang, Mason Bartels, Sophie Dogné, Shangang Zhao, Xi Chen, Clair Crewe, Leon Straub, Lavanya Vishvanath, Zhuzhen Zhang, Mengle Shao, Yongjie Yang, Christy M. Gliniak, Ruth Gordillo, Gordon I. Smith, William L. Holland, Rana K. Gupta, Bingning Dong, Nathalie Caron, Yong Xu, Yucel Akgul, Samuel Klein, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Hyaluronan is a naturally occurring linear polysaccharide that together with collagens, enzymes, and glycoproteins forms the extracellular matrix. Here the authors show that adipose tissue overproduction of Hyaluronan reduces fat accumulation in mice
Externí odkaz:
https://doaj.org/article/d5d6f30432264ee3a4a2783133e16a29
Publikováno v:
eLife, Vol 11 (2022)
The SARS-CoV-2 pandemic continues to rage around the world. At the same time, despite strong public health measures and high vaccination rates in some countries, a post-COVID-19 syndrome has emerged which lacks a clear definition, prevalence, or etio
Externí odkaz:
https://doaj.org/article/f0f3c7db776546e1a867daa2fa107918
Autor:
Jerry R. Colca, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101409- (2022)
Background: Chronic disease appears connected to obesity. However, evidence suggests that chronic metabolic diseases are more specifically related to adipose dysfunction rather than to body weight itself. Scope of review: Further study of the first g
Externí odkaz:
https://doaj.org/article/730da1b080fc46ea9da960e8d195e9cd