Zobrazeno 1 - 10
of 80
pro vyhledávání: '"E S, Vesell"'
Autor:
R, Spector, E S, Vesell
Publikováno v:
Journal of clinical pharmacology. 40(11)
The need for evidence-based medicine as a foundation for optimal patient care requires application of the best scientific methods. Various methods used in the search for clinical truth are discussed. The most powerful method to test a clinical hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e41318efef110719eb8565862d7862f4
https://pubmed.ncbi.nlm.nih.gov/11075306
https://pubmed.ncbi.nlm.nih.gov/11075306
Autor:
D L, Schmucker, E S, Vesell
Publikováno v:
Journal of clinical pharmacology. 39(11)
In many industrialized nations, the elderly comprise the fastest growing subpopulation and constitute an increasing proportion of the total population compared to other age groups. The elderly use a disproportionately larger amount of health care res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9fd6a6f4a9eff86d620a71d69d441a9
https://pubmed.ncbi.nlm.nih.gov/10579140
https://pubmed.ncbi.nlm.nih.gov/10579140
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(4)
Metabolism and disposition of the tobacco-specific N-nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent rodent lung carcinogen, were studied in rhesus monkeys. In three males receiving a single i.v. dose of [5-3H]NNK (0.72 mC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db512d2bfbec6b42c17dbdd7c71c0eb8
https://pubmed.ncbi.nlm.nih.gov/10101142
https://pubmed.ncbi.nlm.nih.gov/10101142
Autor:
E S, Vesell, K H, Beyer
Publikováno v:
Pharmacology. 58(3)
In a three-phase study, single oral doses of placebo, followed in 1 week by pyrazinoylguanidine (PZG; 900 mg), followed in 3 weeks by pyrazinoic acid (PZA; 300 mg) were given to 8 normal male subjects. Blood analyses performed 0, 2 and 4 h after admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79eca4215e299b60f39c6db4d9b1e893
https://pubmed.ncbi.nlm.nih.gov/9925970
https://pubmed.ncbi.nlm.nih.gov/9925970
Publikováno v:
Pharmacology. 54(5)
This study was designed to determine whether pyrazinoylguanidine (PZG) can attenuate cataract development in streptozotocin (STZ)-induced diabetic rats. After a single, intraperitoneal dose of STZ (45 mg/kg in 0.05 mol/l sodium citrate buffer), Sprag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed71c754f4a6327cbdecd31c3919b0c0
https://pubmed.ncbi.nlm.nih.gov/9380771
https://pubmed.ncbi.nlm.nih.gov/9380771
Publikováno v:
Pharmacology. 54(5)
This study was designed to determine whether pyrazinoylguanidine (PZG) can attenuate diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced within 1 week after a single intraperitoneal dose of STZ (45 mg/kg in 0.05 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d6904b29e377531112c7e5538aa23b1
https://pubmed.ncbi.nlm.nih.gov/9380770
https://pubmed.ncbi.nlm.nih.gov/9380770
Publikováno v:
Pharmacology. 53(4)
In isolated rat adipocytes stimulated with theophylline (1 mmol/l), pyrazinoylguanidine (PZG) downregulated both lipolysis and cyclic AMP concentrations, raising the possibility that PZG stimulates adipose insulin-sensitive phosphodiesterase. To inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b1e7c21c74f555b0632882408c39e3c
https://pubmed.ncbi.nlm.nih.gov/8958559
https://pubmed.ncbi.nlm.nih.gov/8958559
Publikováno v:
Pharmacology. 53(4)
The effects of pyrazinoylguanidine (PZG) on lipolysis and intracellular cyclic AMP concentrations were investigated in isolated rat adipocytes. PZG reduced basal cyclic AMP concentrations and blocked in a concentration-dependent manner forskolin (1 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25c23598ce9fc01cdbe3c267f2598b58
https://pubmed.ncbi.nlm.nih.gov/8958558
https://pubmed.ncbi.nlm.nih.gov/8958558