Zobrazeno 1 - 10
of 32
pro vyhledávání: '"E S, Alnemri"'
Autor:
J.-L. Poyet, E. S. Alnemri
Publikováno v:
Nuclear Factor кB ISBN: 9789401039833
Apoptosis (programmed cell death) has a central role in the normal development and homeostasis of all multicellular organisms (Vaux & Strasser, 1996). Deregulation of this process, resulting in too much or too little cell death, can cause both develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b682b26952be15951128b9ab0a26d6
https://doi.org/10.1007/978-94-010-0163-2_3
https://doi.org/10.1007/978-94-010-0163-2_3
Publikováno v:
Cell. 107(3)
Apoptosis is primarily executed by active caspases, which are derived from the inactive procaspase zymogens through proteolytic cleavage. Here we report the crystal structures of a caspase zymogen, procaspase-7, and an active caspase-7 without any bo
Autor:
T, Komata, Y, Kondo, T, Kanzawa, S, Hirohata, S, Koga, H, Sumiyoshi, S M, Srinivasula, B P, Barna, I M, Germano, M, Takakura, M, Inoue, E S, Alnemri, J W, Shay, S, Kyo, S, Kondo
Publikováno v:
Cancer research. 61(15)
Because the apoptotic pathway is often disrupted in tumor cells, its genetic restoration is a very attractive approach for the treatment of tumors. To treat malignant gliomas with this approach, it would be preferred to restrict induction of apoptosi
Publikováno v:
Methods in cell biology. 66
Autor:
J L, Poyet, S M, Srinivasula, J H, Lin, T, Fernandes-Alnemri, S, Yamaoka, P N, Tsichlis, E S, Alnemri
Publikováno v:
The Journal of biological chemistry. 275(48)
To understand the mechanism of activation of the IkappaB kinase (IKK) complex in the tumor necrosis factor (TNF) receptor 1 pathway, we examined the possibility that oligomerization of the IKK complex triggered by ligand-induced trimerization of the
TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis
Autor:
L, Zamai, P, Secchiero, S, Pierpaoli, A, Bassini, S, Papa, E S, Alnemri, L, Guidotti, M, Vitale, G, Zauli
Publikováno v:
Blood. 95(12)
The impact of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) on normal hematopoietic development was investigated using adult peripheral blood CD34(+) hematopoietic progenitor cells, induced to differentiate along the erythroid
Autor:
A, Truneh, S, Sharma, C, Silverman, S, Khandekar, M P, Reddy, K C, Deen, M M, McLaughlin, S M, Srinivasula, G P, Livi, L A, Marshall, E S, Alnemri, W V, Williams, M L, Doyle
Publikováno v:
The Journal of biological chemistry. 275(30)
TRAIL is a member of the tumor necrosis factor (TNF) family of cytokines which induces apoptotic cell death in a variety of tumor cell lines. It mediates its apoptotic effects through one of two receptors, DR4 and DR5, which are members of of the TNF
Autor:
J L, Wang, Z J, Zhang, S, Choksi, S, Shan, Z, Lu, C M, Croce, E S, Alnemri, R, Korngold, Z, Huang
Publikováno v:
Cancer research. 60(6)
Bcl-2 is a potent suppressor of apoptosis, and its overexpression contributes to tumorigenesis in many types of human cancers. To test the possibility of modulating Bcl-2 function as an anticancer strategy, a cell permeable Bcl-2 binding peptide, cel
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(5)
In contrast to positive signaling leading to proliferation, the mechanisms involved in negative signaling culminating in apoptosis after B cell Ag receptor (BCR) ligation have received little study. We find that apoptosis induced by BCR cross-linking