Zobrazeno 1 - 10
of 84
pro vyhledávání: '"E Rand, Sutherland"'
Autor:
E Rand Sutherland, Elena Goleva, Tonya S King, Erik Lehman, Allen D Stevens, Leisa P Jackson, Amanda R Stream, John V Fahy, Donald Y M Leung, Asthma Clinical Research Network
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36631 (2012)
Asthma is a heterogeneous disease with variability among patients in characteristics such as lung function, symptoms and control, body weight, markers of inflammation, and responsiveness to glucocorticoids (GC). Cluster analysis of well-characterized
Externí odkaz:
https://doaj.org/article/6203561102fa45a594a41ca57b6e36f2
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51139 (2012)
BACKGROUND: Nonadherence to medications occurs in up to 70% of patients with asthma. The effect of improving adherence is not well quantified. We developed a mathematical model with which to assess the population-level effects of improving medication
Externí odkaz:
https://doaj.org/article/28b301918028410e8b93a2aa34c4d6f8
Autor:
Neil M.H. Graham, Howard Sofen, Eric L. Simpson, Richard Wu, Ariel Teper, Diamant Thaçi, Thomas Bieber, Marius Ardeleanu, Kim A. Papp, Vera Mastey, Lisa A. Beck, Neil Stahl, George D. Yancopoulos, Jacek C Szepietowski, Gianluca Pirozzi, M. Kawashima, E. Rand Sutherland, Margitta Worm, Steven P. Weinstein, Andrew Blauvelt, Weily Soong
Publikováno v:
The Lancet. 387:40-52
Data from early-stage studies suggested that interleukin (IL)-4 and IL-13 are requisite drivers of atopic dermatitis, evidenced by marked improvement after treatment with dupilumab, a fully-human monoclonal antibody that blocks both pathways. We aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9e1b0f6ac06572ad287fd68c70404f
https://doi.org/10.1016/s0140-6736(15)00388-8
https://doi.org/10.1016/s0140-6736(15)00388-8
CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease
Autor:
Susan Lu, James F. Donohue, Paul Stryszak, Helgo Magnussen, David C. Dale, Stephen I. Rennard, Frank Kanniess, Heribert Staudinger, Henrik Watz, Elizabeth Rosenberg, E. Rand Sutherland
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 191:1001-1011
An antagonist (MK-7123) of the cytokine receptor CXCR2 reduces neutrophil chemotaxis and thus may alleviate airway inflammation in chronic obstructive pulmonary disease (COPD).To assess the efficacy, safety, and tolerability of three dose levels of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c3ca82b09036511ad97e25f290aa87
https://doi.org/10.1164/rccm.201405-0992oc
https://doi.org/10.1164/rccm.201405-0992oc
Autor:
Emiko, Ono, Stefanie, Dutile, Shamsah, Kazani, Michael E, Wechsler, Jun, Yang, Bruce D, Hammock, David Nobuhiro, Douda, Yacine, Tabet, Rayan, Khaddaj-Mallat, Marco, Sirois, Chantal, Sirois, Edmond, Rizcallah, Eric, Rousseau, Richard, Martin, E Rand, Sutherland, Mario, Castro, Nizar N, Jarjour, Elliot, Israel, Bruce D, Levy, Stephen I, Wasserman
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 190:886-897
Rationale: Severe asthma is characterized by airway inflammatory responses associated with aberrant metabolism of arachidonic acid. Lipoxins (LX) are arachidonate-derived pro-resolving mediators that are decreased in severe asthma, yet mechanisms for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d30ec9e60082553c615b73ada8bfa97
https://doi.org/10.1164/rccm.201403-0544oc
https://doi.org/10.1164/rccm.201403-0544oc
Autor:
E. Rand Sutherland
Publikováno v:
Annals of the New York Academy of Sciences. 1311:31-41
A growing body of literature suggests that obesity has a significant impact on asthma risk, phenotype, and prognosis. Epidemiological studies have clearly demonstrated that asthma is more likely to occur in obese patients, and health status is impair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8cd62199c0c03d44df168a4a6a2ee2
https://doi.org/10.1111/nyas.12357
https://doi.org/10.1111/nyas.12357
Autor:
Brendan J. Carolan, E. Rand Sutherland
Publikováno v:
Journal of Allergy and Clinical Immunology. 131:627-634
Asthma and chronic obstructive pulmonary disease (COPD) are prevalent obstructive lung diseases, both of which are characterized by airflow limitation. Although both represent distinct pathogenic entities, there can be significant clinical and physio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50bb30b61b4fb82ac678b3ad2586938
https://doi.org/10.1016/j.jaci.2013.01.010
https://doi.org/10.1016/j.jaci.2013.01.010
Autor:
Vijay N. Joish, Sally E. Wenzel, Jonathan Corren, Lin Wang, Laurent Eckert, E. Rand Sutherland, George D. Yancopoulos, Neil M.H. Graham, Robert Evans, Gianluca Pirozzi, Bingzhi Zhang, Jorge Maspero, Ariel Teper, Mariana Louis-Tisserand, Mario Castro, Neil Stahl
Publikováno v:
Lancet (London, England). 388(10039)
Dupilumab, a fully human anti-interleukin-4 receptor α monoclonal antibody, inhibits interleukin-4 and interleukin-13 signalling, key drivers of type-2-mediated inflammation. Adults with uncontrolled persistent asthma who are receiving medium-to-hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c5bcf33bdc03f551654eee51303191
https://pubmed.ncbi.nlm.nih.gov/28812907
https://pubmed.ncbi.nlm.nih.gov/28812907
Autor:
Andrew Blauvelt, Laurent Eckert, Marius Ardeleanu, Neil M.H. Graham, Vera Mastey, Abhijit Gadkari, Weily Soong, Eric L. Simpson, Richard Wu, Gianluca Pirozzi, E. Rand Sutherland, Margitta Worm
Publikováno v:
Journal of the American Academy of Dermatology. 75(3)
Moderate to severe atopic dermatitis (AD) is associated with substantial patient burden despite current therapies.We sought to evaluate dupilumab treatment on patient-reported outcomes in adults with moderate to severe AD.Adults (N = 380) with modera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db4bb7fb48f73f86f8a13cb36471105
https://pubmed.ncbi.nlm.nih.gov/27268421
https://pubmed.ncbi.nlm.nih.gov/27268421
Publikováno v:
Proceedings of the American Thoracic Society. 9:197-203
A significant proportion of children with asthma who are treated with low-dose inhaled corticosteroids (ICS) continue to experience suboptimal disease control and exacerbations. Despite this, the best approach for escalating therapy in these children
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9723426086faf7ba98b3f0ef381d9892
https://doi.org/10.1513/pats.201206-032tt
https://doi.org/10.1513/pats.201206-032tt