Zobrazeno 1 - 10
of 91
pro vyhledávání: '"E R Podack"'
Publikováno v:
The Journal of Immunology. 163:5178-5182
The endoplasmic reticulum resident heat shock protein gp96 chaperons peptides, including those derived from tumor Ags, on their way to presentation by MHC class I. Replacement of the endoplasmic reticulum retention signal of gp96 with the Fc portion
Publikováno v:
The Journal of Immunology. 158:2648-2653
It has previously been reported that Th1 CD4 T cell populations can be converted to IL-4 producers, whereas Th2 populations are refractory to IL-12-mediated IFN-gamma production. We have recently shown that CD30 is a marker for the IL-4 response and
Publikováno v:
The Journal of Immunology. 158:2090-2098
Prior studies have implicated CD30 as a marker for Th2 cells, but the mechanism that underlies this correlation was unknown. We show here that CD30 was expressed on activated CD4+ T cells in the presence of IL-4. In the absence of endogenously produc
Publikováno v:
The Journal of Immunology. 157:4347-4353
Overexpression of B7 and intracellular adhesion molecule-1 (ICAM-1) on syngeneic cells triggered MHC-unrestricted lysis by MHC-restricted CD8+ CTL without TCR/CD3 engagement. Both CD28/B7 and LFA-1/ICAM-1 interactions were required for MHC-nonrestric
Publikováno v:
The Journal of Immunology. 157:1919-1925
Lymphokine-activated killer (LAK) cells generated from perforin knockout mice possess significantly reduced cytotoxicity against a panel of tumor target cell lines, with some tumor cells being lysed exclusively by the perforin pathway. LAK cells are
Publikováno v:
The Journal of Immunology. 156:442-449
Murine CD30 cDNA predicts a protein of 498 amino acids with homology to the TNF receptor family of proteins characterized by repeated cysteine-rich motifs in the extracellular domain. Murine CD30, although homologous to human CD30, has a 90 amino aci
Transgenic control of perforin gene expression. Functional evidence for two separate control regions
Publikováno v:
The Journal of Immunology. 154:2153-2163
Perforin is a pore-forming effector molecule of CTL and NK cells. To characterize perforin gene expression and its transcriptional control mechanisms in vivo, expression of a cell surface tag, i.e., human CD4, was driven by 5.1 kb of the murine perfo
Publikováno v:
Clinical and Experimental Immunology. 98:470-477
SUMMARYInfiltration of the thyroid gland by lymphocytes is a hall-mark of autoimmune thyroid disease; it is particularly evident in Hashimoto's thyroiditis but is also seen in most patients with Graves’ disease. Infiltrating cells are comprised pri
Autor:
E P Miskovsky, A Y Liu, W Pavlat, R Viveen, P E Stanhope, D Finzi, W M Fox, R H Hruban, E R Podack, R F Siliciano
Publikováno v:
The Journal of Immunology. 153:2787-2799
Vaccine-induced, virus-specific CTLs may rapidly eliminate the host cells that first become infected after virus exposure, thereby preventing disseminated infection. Thus, there is much interest in the ability of candidate AIDS vaccines to elicit CTL