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Low-abundance HIV species and their impact on mutational profiles in patients with virological failure on once-daily abacavir/lamivudine/zidovudine and tenofovir

Autor: Joseph Horton, Belinda Ha, Lisa L. Ross, Richard Elion, E. R. Lanier, C. Cohen, Peter Gerondelis, E. Rouse, Edwin DeJesus

Publikováno v: Journal of Antimicrobial Chemotherapy

Background HIV clonal genotypic analysis (CG) was used to investigate whether a more sensitive analysis method would detect additional low-abundance mutations compared with population genotyping (PG) in antiretroviral-naive patients who experienced v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e86fe8dc69e8a4e9a1e43f4637160a
https://doi.org/10.1093/jac/dkp419

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The Efficacy of Potent Anti-retroviral Drug Combinations Tested in a Murine Model of HIV-1 Encephalitis

Autor: J. Rasmussen, Howard E. Gendelman, Marina Zelivyanskaya, Larisa Y. Poluektova, W. Ratanasuwan, Jenae Limoges, D. R. McClernon, Y. Persidsky, E. R. Lanier

Publikováno v: Virology. 281(1):21-34

Development of anti-retroviral regimens with enhanced efficacy against brain HIV-1 is essential if viral eradication is to be achieved. To address this, a severe combined immune deficiency mouse model of HIV-1 encephalitis was used to assay the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855af6a173f5c965c253bf4e76c9c247

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Treatment Intensification with Abacavir in HIV-Infected Patients with at Least 12 Weeks Previous Lamivudine/Zidovudine Treatment

Autor: Willy Rozenbaum, Jean-François Delfraissy, J P Mamet, P Massip, M. Bentata, C Vavro, F David, E R Lanier, C Trepo, Christine Katlama, David Zucman

Publikováno v: Antiviral Therapy. 6:135-142

Objectives To demonstrate that lamivudine and zidovudine, given separately (lamivudine/zidovudine) or as a single combination tablet (Combivir™), had equivalent efficacy. To evaluate the safety and antiretroviral activity of intensification with ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d3db7faf2f78abe26527d58cd1a3548
https://doi.org/10.1177/135965350100600207

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Treatment intensification with abacavir in HIV-infected patients with at least 12 weeks previous lamivudine/zidovudine treatment

Autor: W, Rozenbaum, C, Katlama, P, Massip, M, Bentata, D, Zucman, J F, Delfraissy, C, Trepo, F, David, E R, Lanier, C, Vavro, J P, Mamet

Publikováno v: Antiviral therapy. 6(2)

To demonstrate that lamivudine and zidovudine, given separately (lamivudine/zidovudine) or as a single combination tablet (Combivir), had equivalent efficacy. To evaluate the safety and antiretroviral activity of intensification with abacavir in pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::042a3a568746bf5e85c17e9516748187
https://pubmed.ncbi.nlm.nih.gov/11491418

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Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus

Autor: L, Yang, E R, Lanier, E, Kraig

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(6)

A conserved decamer sequence, AGTGA(T/C)(G/A)TCA, related to the cAMP response element (CRE), is found in the promoter regions of most TCR V beta gene segments. It has been shown to be a critical element for T cell-specific transcriptional regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67c1929f38ee10025d53ac636726defb
https://pubmed.ncbi.nlm.nih.gov/9058782

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Evaluation of antiretroviral drug efficacy for HIV-1 encephalitis in SCID mice

Autor: W. Ratanasuwan, Jenae Limoges, J. Rasmussen, Marina Zelivyanskaya, Larisa Y. Poluektova, D. R. McClernon, Howard E. Gendelman, E. R. Lanier, Y. Persidsky

Publikováno v: Neurology. 54:379-379

Objectives: To compare the efficacy of the nucleoside reverse transcriptase inhibitors (NRTIs) abacavir, zidovudine (AZT), lamivudine (3TC), didanosine (ddI), and stavudine (d4T) to inhibit viral replication in brain macrophages. A severe combined im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e90239ff5a0a0cf31beedf7eb20e6a3
https://doi.org/10.1212/wnl.54.2.379

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