Zobrazeno 1 - 6
of 6
pro vyhledávání: '"E R, Meaden"'
Autor:
David Back, Saye Khoo, Philippa Newton, Ian S. Williams, E. R. Meaden, Patrick G. Hoggard, D. Aldam, John Tjia, David Cornforth, J Lloyd
Publikováno v:
Journal of Antimicrobial Chemotherapy. 50:583-588
Objectives: Efflux transporters may play a role in lowering intracellular drug concentrations. As the HIV protease inhibitors are substrates for the efflux transporters P-glycoprotein and MRP, we wished to investigate whether differences in expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9204008d465f9b8588be58bd021957
https://doi.org/10.1093/jac/dkf161
https://doi.org/10.1093/jac/dkf161
Determination of P-gp and MRP1 expression and function in peripheral blood mononuclear cells in vivo
Publikováno v:
Journal of Immunological Methods. 262:159-165
P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) mediate the efflux of many therapeutic agents and have been implicated in the treatment failure of many infectious diseases and cancers. The ability to characterise the expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2a74dd1b6fb2e0dc314ba38c15156e
https://doi.org/10.1016/s0022-1759(02)00020-0
https://doi.org/10.1016/s0022-1759(02)00020-0
Publikováno v:
AIDS Research and Human Retroviruses. 17:1329-1332
Increased expression of the multidrug efflux transporters P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) has been suggested as a potential mechanism for decreased drug availability at certain intracellular sites that provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a58b59a4358a4cd7a33e3291b324a2a
https://doi.org/10.1089/08892220152596588
https://doi.org/10.1089/08892220152596588
Autor:
Ross A. Davey, Patrick G. Bray, Saye Khoo, David Back, Stephen A. Ward, Kevin E. Jones, E. R. Meaden
Publikováno v:
AIDS. 15:1353-1358
Background: The multidrug transporters P-glycoprotein (P-gp) and MRP1 are functionally expressed in several subclasses of lymphocytes. HIV-1 protease inhibitors interact with both; consequently the transporters could reduce the local concentration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238996ee18bdd61106c1fa736630ffb9
https://doi.org/10.1097/00002030-200107270-00004
https://doi.org/10.1097/00002030-200107270-00004
Autor:
Saye Khoo, Mark Dalton, J. Ford, E. R. Meaden, Philippa Newton, Ian S. Williams, David Back, Patrick G. Hoggard
Publikováno v:
The Journal of antimicrobial chemotherapy. 52(3)
BACKGROUND: Increased expression of multidrug resistance transporters, such as P-glycoprotein (P-gp), has been suggested as a potential mechanism for decreased protease inhibitor (PI) availability at certain intracellular sites and tissue compartment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f1cd9319a1dcdaa8fd523c50f692e6
https://pubmed.ncbi.nlm.nih.gov/12917239
https://pubmed.ncbi.nlm.nih.gov/12917239
Publikováno v:
AIDS research and human retroviruses. 17(14)
Increased expression of the multidrug efflux transporters P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) has been suggested as a potential mechanism for decreased drug availability at certain intracellular sites that provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09a4cf050ceb31c0d7b9a25ce42e554d
https://pubmed.ncbi.nlm.nih.gov/11602043
https://pubmed.ncbi.nlm.nih.gov/11602043